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Acta Parasitologica


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Volume 58, Issue 4

Issues

Associations between Demodex species infestation and various types of cancer

Özlem Sönmez / Zeliha Yalçın / Engin Karakeçe / İhsan Çiftci / Teoman Erdem
Published Online: 2013-12-13 | DOI: https://doi.org/10.2478/s11686-013-0178-y

Abstract

Tumor-associated immune system cells secrete protease and cytokines that can inhibit the immune response. In particular, T-cell effector functions could be inhibited, potentially causing an increase in parasitic infestations. Demodex species are common inhabitants of normal hair follicles. Humans are the specific host for two species Demodex folliculorum and D. brevis. The aim of this study was to investigate the incidence and infestation of D. folliculorum and D. brevis in patients with cancer. In the present study, 101 patients with cancer were selected from among patients who were diagnosed and treated for cancer. The cancer patients were divided into four groups according to cancer type. Slides were examined for parasites using light microscopy at magnifications of ×40 and ×100. Infestation was defined as having at least five living parasites/cm2 of skin. The ages of the patients with cancer ranged between 38 and 82 years, with a mean of 65.5±10.1 years. It was determined that 77 of the 101 (76.2%) cancer patients were positive for Demodex species. Infestation was positive in 18 (47.4%) of the 38 cases in the breast cancer group, 7 (29.2%) of the 24 cases in the lung cancer group, 5 (18.5%) of the 27 cases in the gastrointestinal system cancer group, and 2 (16.7%) of the 12 cases in the urogenital system cancer group. Results showed that the rate of Demodex species infestation was higher in patients with breast cancer. Thus, cancer — and particularly breast cancer — is a risk factor for Demodex species infestation.

Keywords: Cancer; risk factor; Demodex; infestation

  • [1] Akdeniz S., Bahceci M., Tuzcu A.K., Harman M., Alp S., Bahceci S. 2002. Is Demodex folliculorum larger in diabetic patients?. Journal of the European Academy of Dermatology and Venereology, 16, 539–541. http://dx.doi.org/10.1046/j.1468-3083.2002.00545_7.xCrossrefGoogle Scholar

  • [2] Akilov O.E., Mumcuoglu K.Y. 2003. Association between human demodicosis and HLA class I. Clinical and Experimental Dermatology, 28, 70–73. http://dx.doi.org/10.1046/j.1365-2230.2003.01173.xCrossrefGoogle Scholar

  • [3] Akilov O.E., Mumcuoglu K.Y. 2004. Immune response in demodicosis. Journal of the European Academy of Dermatology and Venereology, 18, 440–444. http://dx.doi.org/10.1111/j.1468-3083.2004.00964.xCrossrefGoogle Scholar

  • [4] Baima B., Sticherling M. 2002. Demodicidosis revisited. Acta Dermato-Venereologica, 82, 3–6. http://dx.doi.org/10.1080/000155502753600795CrossrefGoogle Scholar

  • [5] Ciftci I.H., Dundar U., Cetinkaya Z., Kulac M., Kiyildı N., Turel A., Evcik D., Kavuncu V. 2007. Demodex folliculorum in patients with rheumatoid arthritis. Acta Parasitologica, 52, 70–73. DOI: 10.2478/s11686-007-0002-7. http://dx.doi.org/10.2478/s11686-007-0002-7Web of ScienceCrossrefGoogle Scholar

  • [6] Cogen A.L., Nizet V., Gallo R.L. 2008. Skin microbiota: a source of disease or defence? British Journal of Dermatology, 158, 442–455. DOI: 10.1111/j.1365-2133.2008.08437.x. http://dx.doi.org/10.1111/j.1365-2133.2008.08437.xCrossrefWeb of ScienceGoogle Scholar

  • [7] Dahl M.V., Ross A.J., Schlievert P.M. 2004. Temperature regulates bacterial protein production: possible role in rosacea. Journal of the American Academy of Dermatology, 50, 266–272. http://dx.doi.org/10.1016/j.jaad.2003.05.005CrossrefGoogle Scholar

  • [8] Damian D., Rogers M. 2003. Demodex infestation in a child with leukaemia: treatment with ivermectin and permethrin. International Journal of Dermatology, 42, 724–726. http://dx.doi.org/10.1046/j.1365-4362.2003.01916.xCrossrefGoogle Scholar

  • [9] Dong H., Duncan L.D. 2006. Cytologic findings in Demodex folliculitis: a case report and review of the literature. Diagnostic Cytopathology, 34, 232–234. http://dx.doi.org/10.1002/dc.20426CrossrefWeb of ScienceGoogle Scholar

  • [10] Erbagci Z., Erbagci I., Erkilic S. 2003. High incidence of demodicidosis in eyelid basal cell carcinomas. Intrnational Journal of Dermatology, 42, 567–571. http://dx.doi.org/10.1046/j.1365-4362.2003.01928.xCrossrefGoogle Scholar

  • [11] Ferlay J., Shin H.R., Bray F., Forman D., Mathers C., Parkin D.M. 2010. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. International Journal of Cancer, 127, 2893–2917. DOI: 10.1002/ijc.25516. http://dx.doi.org/10.1002/ijc.25516CrossrefGoogle Scholar

  • [12] George K.K. Lau. 2008. Hepatitis B reactivation after chemotherapy: two decades of clinical research. Hepatology International, 2, 152–162. DOI: 10.1007/s12072-008-9056-3. http://dx.doi.org/10.1007/s12072-008-9056-3Web of ScienceCrossrefGoogle Scholar

  • [13] Gerber P.A., Kukova G., Buhren B.A., Homey B. 2011. Density of Demodex folliculorum in patients receiving epidermal growth factor receptor inhibitors. Dermatology, 222, 144–147. DOI: 10.1159/000323001. http://dx.doi.org/10.1159/000323001CrossrefWeb of ScienceGoogle Scholar

  • [14] Jansen T., Kastner U., Kreuter A., Altmeyer P. 2001. Rosacea-like demodicidosis associated with Acquired İmmunodeficiency Syndrome. British Journal Dermatology, 144, 139–142. http://dx.doi.org/10.1046/j.1365-2133.2001.03794.xCrossrefGoogle Scholar

  • [15] Karaman U., Sener S., Samdanci E., Colak C., Sasmaz S. 2010. The incidence of Demodex species in skin biopsy specimens diagnosed as actinic keratosis and nonmelanoma skin cancer. Asian Biomedicine, 4, 343–348. Google Scholar

  • [16] Kulac M., Ciftci I.H., Karaca S., Cetinkaya Z. 2008. Clinical importance of Demodex folliculorum in patients receiving phototherapy. International Journal Dermatology, 47, 72–77. DOI: 10.1111/j.1365-4632.2007.03336.x. http://dx.doi.org/10.1111/j.1365-4632.2007.03336.xCrossrefGoogle Scholar

  • [17] Lacey N., Raghallaigh S.N., Powel F.C. 2011. Demodex mites-commensal, parasites of mutualistic organisms?. Dermatology, 222, 128–130. DOI: 10.1159/000323009. http://dx.doi.org/10.1159/000323009CrossrefWeb of ScienceGoogle Scholar

  • [18] Morras P.G., Santos S.P., Imedio I.L., Echeverria M.L., Hermosa J.M. 2003. Rosacae-like Demodicidosis in an immunocompromised child. Pediatric Dermatology, 20, 28–30. http://dx.doi.org/10.1046/j.1525-1470.2003.03006.xCrossrefGoogle Scholar

  • [19] Patrizi A., Neri I., Chieregato C., Misciali M. 1997. Demodicidosis in immunocompetent young children: report of eight cases. Dermatology, 195, 239–242. http://dx.doi.org/10.1159/000245951CrossrefGoogle Scholar

  • [20] Seyhan M.E., Karincaoglu Y., Bayram N. Aycan O., Kuku I. 2004. Density of Demodex folliculorum in haematological malignancies. Journal of International Medical Research, 32, 411–415. http://dx.doi.org/10.1177/147323000403200410CrossrefGoogle Scholar

  • [21] Sun J., Gui X., He J., Liu H.M., Yu H.Y., Xia C.Y., Xu Y. 2005. The relationship between infestation of Demodex folliculorum and epidermal neoplasm on face. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi, 23, 428–431. Google Scholar

  • [22] Whitfeld M., Gunasingam N., Leow L.J., Shirato K., Preda V. 2011. Staphylococcus epidermidis: a possible role in the pustules of rosacea. Journal of the American Academy of Dermatology, 64, 49–52. DOI: 10.1016/j.jaad.2009.12.036. http://dx.doi.org/10.1016/j.jaad.2009.12.036CrossrefWeb of ScienceGoogle Scholar

  • [23] Yang L., Carbone D.P. 2004. Tumor-Host Immune Interactions and Dendritic Cell Dysfunction. Advances in Cancer Research, 92, 13–27. Google Scholar

About the article

Published Online: 2013-12-13

Published in Print: 2013-12-01


Citation Information: Acta Parasitologica, Volume 58, Issue 4, Pages 551–555, ISSN (Online) 1896-1851, ISSN (Print) 1230-2821, DOI: https://doi.org/10.2478/s11686-013-0178-y.

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© 2013 W. Stefański Institute of Parasitology, PAS. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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