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BY-NC-ND 3.0 license Open Access Published by De Gruyter December 13, 2013

Associations between Demodex species infestation and various types of cancer

  • Özlem Sönmez EMAIL logo , Zeliha Yalçın , Engin Karakeçe , İhsan Çiftci and Teoman Erdem
From the journal Acta Parasitologica

Abstract

Tumor-associated immune system cells secrete protease and cytokines that can inhibit the immune response. In particular, T-cell effector functions could be inhibited, potentially causing an increase in parasitic infestations. Demodex species are common inhabitants of normal hair follicles. Humans are the specific host for two species Demodex folliculorum and D. brevis. The aim of this study was to investigate the incidence and infestation of D. folliculorum and D. brevis in patients with cancer. In the present study, 101 patients with cancer were selected from among patients who were diagnosed and treated for cancer. The cancer patients were divided into four groups according to cancer type. Slides were examined for parasites using light microscopy at magnifications of ×40 and ×100. Infestation was defined as having at least five living parasites/cm2 of skin. The ages of the patients with cancer ranged between 38 and 82 years, with a mean of 65.5±10.1 years. It was determined that 77 of the 101 (76.2%) cancer patients were positive for Demodex species. Infestation was positive in 18 (47.4%) of the 38 cases in the breast cancer group, 7 (29.2%) of the 24 cases in the lung cancer group, 5 (18.5%) of the 27 cases in the gastrointestinal system cancer group, and 2 (16.7%) of the 12 cases in the urogenital system cancer group. Results showed that the rate of Demodex species infestation was higher in patients with breast cancer. Thus, cancer — and particularly breast cancer — is a risk factor for Demodex species infestation.

[1] Akdeniz S., Bahceci M., Tuzcu A.K., Harman M., Alp S., Bahceci S. 2002. Is Demodex folliculorum larger in diabetic patients?. Journal of the European Academy of Dermatology and Venereology, 16, 539–541. http://dx.doi.org/10.1046/j.1468-3083.2002.00545_7.x10.1046/j.1468-3083.2002.00545_7.xSearch in Google Scholar PubMed

[2] Akilov O.E., Mumcuoglu K.Y. 2003. Association between human demodicosis and HLA class I. Clinical and Experimental Dermatology, 28, 70–73. http://dx.doi.org/10.1046/j.1365-2230.2003.01173.x10.1046/j.1365-2230.2003.01173.xSearch in Google Scholar PubMed

[3] Akilov O.E., Mumcuoglu K.Y. 2004. Immune response in demodicosis. Journal of the European Academy of Dermatology and Venereology, 18, 440–444. http://dx.doi.org/10.1111/j.1468-3083.2004.00964.x10.1111/j.1468-3083.2004.00964.xSearch in Google Scholar PubMed

[4] Baima B., Sticherling M. 2002. Demodicidosis revisited. Acta Dermato-Venereologica, 82, 3–6. http://dx.doi.org/10.1080/00015550275360079510.1080/000155502753600795Search in Google Scholar PubMed

[5] Ciftci I.H., Dundar U., Cetinkaya Z., Kulac M., Kiyildı N., Turel A., Evcik D., Kavuncu V. 2007. Demodex folliculorum in patients with rheumatoid arthritis. Acta Parasitologica, 52, 70–73. DOI: 10.2478/s11686-007-0002-7. http://dx.doi.org/10.2478/s11686-007-0002-710.2478/s11686-007-0002-7Search in Google Scholar

[6] Cogen A.L., Nizet V., Gallo R.L. 2008. Skin microbiota: a source of disease or defence? British Journal of Dermatology, 158, 442–455. DOI: 10.1111/j.1365-2133.2008.08437.x. http://dx.doi.org/10.1111/j.1365-2133.2008.08437.x10.1111/j.1365-2133.2008.08437.xSearch in Google Scholar PubMed PubMed Central

[7] Dahl M.V., Ross A.J., Schlievert P.M. 2004. Temperature regulates bacterial protein production: possible role in rosacea. Journal of the American Academy of Dermatology, 50, 266–272. http://dx.doi.org/10.1016/j.jaad.2003.05.00510.1016/j.jaad.2003.05.005Search in Google Scholar PubMed

[8] Damian D., Rogers M. 2003. Demodex infestation in a child with leukaemia: treatment with ivermectin and permethrin. International Journal of Dermatology, 42, 724–726. http://dx.doi.org/10.1046/j.1365-4362.2003.01916.x10.1046/j.1365-4362.2003.01916.xSearch in Google Scholar PubMed

[9] Dong H., Duncan L.D. 2006. Cytologic findings in Demodex folliculitis: a case report and review of the literature. Diagnostic Cytopathology, 34, 232–234. http://dx.doi.org/10.1002/dc.2042610.1002/dc.20426Search in Google Scholar PubMed

[10] Erbagci Z., Erbagci I., Erkilic S. 2003. High incidence of demodicidosis in eyelid basal cell carcinomas. Intrnational Journal of Dermatology, 42, 567–571. http://dx.doi.org/10.1046/j.1365-4362.2003.01928.x10.1046/j.1365-4362.2003.01928.xSearch in Google Scholar PubMed

[11] Ferlay J., Shin H.R., Bray F., Forman D., Mathers C., Parkin D.M. 2010. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. International Journal of Cancer, 127, 2893–2917. DOI: 10.1002/ijc.25516. http://dx.doi.org/10.1002/ijc.2551610.1002/ijc.25516Search in Google Scholar PubMed

[12] George K.K. Lau. 2008. Hepatitis B reactivation after chemotherapy: two decades of clinical research. Hepatology International, 2, 152–162. DOI: 10.1007/s12072-008-9056-3. http://dx.doi.org/10.1007/s12072-008-9056-310.1007/s12072-008-9056-3Search in Google Scholar PubMed PubMed Central

[13] Gerber P.A., Kukova G., Buhren B.A., Homey B. 2011. Density of Demodex folliculorum in patients receiving epidermal growth factor receptor inhibitors. Dermatology, 222, 144–147. DOI: 10.1159/000323001. http://dx.doi.org/10.1159/00032300110.1159/000323001Search in Google Scholar PubMed

[14] Jansen T., Kastner U., Kreuter A., Altmeyer P. 2001. Rosacea-like demodicidosis associated with Acquired İmmunodeficiency Syndrome. British Journal Dermatology, 144, 139–142. http://dx.doi.org/10.1046/j.1365-2133.2001.03794.x10.1046/j.1365-2133.2001.03794.xSearch in Google Scholar PubMed

[15] Karaman U., Sener S., Samdanci E., Colak C., Sasmaz S. 2010. The incidence of Demodex species in skin biopsy specimens diagnosed as actinic keratosis and nonmelanoma skin cancer. Asian Biomedicine, 4, 343–348. Search in Google Scholar

[16] Kulac M., Ciftci I.H., Karaca S., Cetinkaya Z. 2008. Clinical importance of Demodex folliculorum in patients receiving phototherapy. International Journal Dermatology, 47, 72–77. DOI: 10.1111/j.1365-4632.2007.03336.x. http://dx.doi.org/10.1111/j.1365-4632.2007.03336.x10.1111/j.1365-4632.2007.03336.xSearch in Google Scholar PubMed

[17] Lacey N., Raghallaigh S.N., Powel F.C. 2011. Demodex mites-commensal, parasites of mutualistic organisms?. Dermatology, 222, 128–130. DOI: 10.1159/000323009. http://dx.doi.org/10.1159/00032300910.1159/000323009Search in Google Scholar PubMed

[18] Morras P.G., Santos S.P., Imedio I.L., Echeverria M.L., Hermosa J.M. 2003. Rosacae-like Demodicidosis in an immunocompromised child. Pediatric Dermatology, 20, 28–30. http://dx.doi.org/10.1046/j.1525-1470.2003.03006.x10.1046/j.1525-1470.2003.03006.xSearch in Google Scholar PubMed

[19] Patrizi A., Neri I., Chieregato C., Misciali M. 1997. Demodicidosis in immunocompetent young children: report of eight cases. Dermatology, 195, 239–242. http://dx.doi.org/10.1159/00024595110.1159/000245951Search in Google Scholar PubMed

[20] Seyhan M.E., Karincaoglu Y., Bayram N. Aycan O., Kuku I. 2004. Density of Demodex folliculorum in haematological malignancies. Journal of International Medical Research, 32, 411–415. http://dx.doi.org/10.1177/14732300040320041010.1177/147323000403200410Search in Google Scholar PubMed

[21] Sun J., Gui X., He J., Liu H.M., Yu H.Y., Xia C.Y., Xu Y. 2005. The relationship between infestation of Demodex folliculorum and epidermal neoplasm on face. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi, 23, 428–431. Search in Google Scholar

[22] Whitfeld M., Gunasingam N., Leow L.J., Shirato K., Preda V. 2011. Staphylococcus epidermidis: a possible role in the pustules of rosacea. Journal of the American Academy of Dermatology, 64, 49–52. DOI: 10.1016/j.jaad.2009.12.036. http://dx.doi.org/10.1016/j.jaad.2009.12.03610.1016/j.jaad.2009.12.036Search in Google Scholar PubMed

[23] Yang L., Carbone D.P. 2004. Tumor-Host Immune Interactions and Dendritic Cell Dysfunction. Advances in Cancer Research, 92, 13–27. Search in Google Scholar

Published Online: 2013-12-13
Published in Print: 2013-12-1

© 2013 W. Stefański Institute of Parasitology, PAS

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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