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Volume 58, Issue 4

Issues

Human dirofilariasis due to Dirofilaria repens in Ukraine, an emergent zoonosis: epidemiological report of 1465 cases

Rusłan Sałamatin
  • Department of General Biology and Parasitology, Medical University of Warsaw, Warsaw, Poland
  • Department of Medical Parasitology, National Institute of Public Health — National Institute of Hygiene, Warsaw, Poland
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/ Tamara Pavlikovska / Olga Sagach / Svitlana Nikolayenko / Vadim Kornyushin / Vitaliy Kharchenko / Aleksander Masny
  • Department of Medical Parasitology, National Institute of Public Health — National Institute of Hygiene, Warsaw, Poland
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/ Danuta Cielecka
  • Department of General Biology and Parasitology, Medical University of Warsaw, Warsaw, Poland
  • Department of Medical Parasitology, National Institute of Public Health — National Institute of Hygiene, Warsaw, Poland
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/ Joanna Konieczna-Sałamatin / David Conn / Elzbieta Golab
  • Department of Medical Parasitology, National Institute of Public Health — National Institute of Hygiene, Warsaw, Poland
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Published Online: 2013-12-13 | DOI: https://doi.org/10.2478/s11686-013-0187-x

Abstract

The filarial nematode Dirofilaria repens is currently considered to be one of the most extensively spreading human and animal parasites in Europe. In Ukraine, reporting cases of dirofilariasis has been mandatory since 1975, and the disease was included in the national surveillance system for notifiable diseases. Up until December 31st 2012, a total of 1533 cases have been registered, with 1465 cases occurring within the previous 16 years. Most of the cases of dirofilariasis were registered in 6 regions: Kyiv, and the Donetsk, Zaporizhzhya, Dnipropetrovsk, Kherson and Chernihiv oblasts. In the years 1997–2002 the highest incidence rate was noted in the Kherson oblast in the south of the country (9.79 per 100 000 people), and the lowest in western Ukraine (0.07–1.68 per 100 000 people). D. repens infections were registered in all oblasts. Parasitic lesions were most often located in the head, the subconjunctival tissue and around the eyes. D. repens lesions were also found in the limbs, torso, male sexual organs, and female mammary glands. Dirofilariasis was diagnosed in persons aged from 11 months to 90 years old, most often among people between 21–40 years of age. Most patients had only one parasitic skin lesion; the majority of isolated nematodes were female. The results of our analysis point to a constant increase in D. repens dirofilariasis incidence in humans in Ukraine. Despite educational efforts, infections have become more frequent and the territory in which the disease occurs has enlarged to encompass the whole of Ukraine. Nevertheless, the Ukrainian sanitary-epidemiological services managed to achieve some measure of success, e.g. by creating a registration system for D. repens infections and establishing proper diagnostics for the disease.

Keywords: Dirofilariasis; Dirofilaria repens; human; epidemiology; Ukraine; Europe

  • [1] Anonymous. 1975. [Clinical cases of dirofilariasis in humans]. Medicinskaa Parazitologia i Parazitarnye Bolezni, 44, 616 (In Russian). PMid: 1219362. Google Scholar

  • [2] Babal P., Kobzova D., Novak I., Dubinsky P., Jalili N. 2008. First case of cutaneous human dirofilariosis in Slovak Republic. Bratislavské Lekárske Listy, 109, 486–488. PMid: 19205556. Google Scholar

  • [3] Babes V. 1879. Ueber einen neuen Parasiten des Menschen. Medizinisch-chirurgisches Centralblatt, 14, 554. Google Scholar

  • [4] Babesiu V. 1880. Ueber einen im menschlichen Peritonäum gefundenen Nematoden. Archiv für pathologische Anatomie und Physiologie und für klinische Medicin, 81, 158–165. http://dx.doi.org/10.1007/BF01995475Google Scholar

  • [5] Babìčenko V.M., Guŝina L.M., Kozel S.V., Nìkolaêva N.V., Rudššina S.F. 2007. Air temperature (July). In: (Ed. L. G. Rudenko) Nacìonalńij Atlas Ukraïni, Kyiv, Kartografìa, p. 167 (In Ukrainian). Google Scholar

  • [6] Bolgarenko A.V. 2001. [Human dirofilariasis in the Nikolaev region]. Medicinskaa Parazitologia i Parazitarnye Bolezni, 3, 57–58 (In Russian). PMid: 11680379. Google Scholar

  • [7] Cielecka D., Żarnowska-Prymek H., Masny A., Salamatin R., Wesołowska M., Gołąb E. 2012. Human dirofilariosis in Poland: the first cases of autochthonous infections with Dirofilaria repens. Annals of Agricultural and Environmental Medicine: AAEM, 19, 445–450. PMid: 23020037. Google Scholar

  • [8] Èngel’štejn A.S., Kigel’ R.M., Zaporožec G.I. 1973. [Human invasion by Dirofilaria repens]. Medicinskaa Parazitologia i Parazitarnye Bolezni, 42, 35 (In Russian). PMid: 4770433. Google Scholar

  • [9] Genchi C., Rinaldi L., Mortarino M., Genchi M., Cringoli G. 2009. Climate and Dirofilaria infection in Europe. Veterinary Parasitology, 163, 286–292. DOI: 10.1016/j.vetpar.2009.03.026. http://dx.doi.org/10.1016/j.vetpar.2009.03.026CrossrefPubMedWeb of ScienceGoogle Scholar

  • [10] Genchi C., Kramer L.H., Rivasi F. 2011a. Dirofilarial infections in Europe. Vector-Borne and Zoonotic Diseases, 11, 1307–1317. DOI: 10.1089/vbz.2010.0247. http://dx.doi.org/10.1089/vbz.2010.0247Web of ScienceCrossrefGoogle Scholar

  • [11] Genchi C., Mortarino M., Rinaldi L., Cringoli G., Traldi G., Genchi M. 2011b. Changing climate and changing vector-borne disease distribution: the example of Dirofilaria in Europe. Veterinary Parasitology, 176, 295–299. DOI: 10.1016/j.vetpar.2011.01.012. http://dx.doi.org/10.1016/j.vetpar.2011.01.012CrossrefWeb of ScienceGoogle Scholar

  • [12] Gerbilśkij V.L. 1951. [Experiences of an academic medical department in providing expert assistance to health care providers]. Medicinskaa Parazitologia i Parazitarnye Bolezni, 20, 264–266 (In Russian). Google Scholar

  • [13] Gerbilśkij V.L, Dorogań D.A. 1961. [A case of dirofilariasis in man]. In: Problemy Parazitologii. Trudy Ukrainskogo Respublikanskogo Naučnogo Obŝestva Parazitologov, No. 1, Kyiv, 339–44 (In Russian). Google Scholar

  • [14] Gogina N.D. 1970. [Subcutaneous dirofilariasis of the lower eyelid]. Oftal’mologičeskij Žurnal, 25, 465–466 (In Russian). PMid: 5511008. Web of ScienceGoogle Scholar

  • [15] Gudumac E., Plăcintă G., Vulpe V., Raducan M. 2011. Dirofilarioza subcutană — prezentare de caz clinic. Anale Ştiinţifice = Scientific Annals, 14, 17–19 (In Moldovan). Google Scholar

  • [16] Kuzmin Yu., Varodi E., Vasylyk N., Kononko G. 2005. Experimental infection of mosquitoes with Dirofilaria repens (Nematoda, Filarioidea) larvae. Vestnik Zoologii, 39, 19–24. Google Scholar

  • [17] Mănescu R., Bărăscu D., Mocanu C., Pîrvănescu H., Mîndriă I., Bălăşoiu M., Turculeanu A. 2009. Nodul subconjunctival cu Dirofilaria repens. Chirurgia. Uniunea Societătilor de Stiinte Medicale din Romania, 104, 95–97 (In Romanian). PMid: 19388575. Google Scholar

  • [18] Masny A., Gołąb E., Cielecka D., Sałsamatin R. 2013. Vector-borne helminths of dogs and humans — focus on central and eastern parts of Europe. Parasites and Vectors, 6, 38. DOI: 10.1186/1756-3305-6-38. http://dx.doi.org/10.1186/1756-3305-6-38CrossrefGoogle Scholar

  • [19] Melńičenko A.P., Prosvetova T.A. 1971. [Second case of human dirofilariasis in the Poltava region]. Medicinskaa Parazitologia i Parazitarnye Bolezni, 40, 238–239 (In Russian). PMid: 5568413. Google Scholar

  • [20] Mukvoz L.G., Belozerskaa N.I. 1975. [Two clinical cases of human dirofilariasis in the town of Zaporozhie]. Medicinskaa Parazitologia i Parazitarnye Bolezni, 44, 615 (In Russian). PMid: 1219361. Google Scholar

  • [21] Naralenkova E.I. 2004. [Notification of cases of dirofilariasis in the Gomel region]. Medicinskaa Parazitologia i Parazitarnye Bolezni, 2, 49–51. PMid: 15193055. Google Scholar

  • [22] Novak V.A., Drozdov A.A., Gribonosov S.N., Lapikova N.V. 2010. [Cases of parasitic invasion of the eyeball and adnexa in humans]. In: Materìali XII Z’izdu Oftal’mologìv Ukraïni, 26–28 travna 2010 r., Odesa, p. 302 (In Russian). Google Scholar

  • [23] Pampiglione S., Canestri Trotti G., Rivasi F. 1995. Human dirofilariasis due to Dirofilaria (Nochtiella) repens: a review of world literature. Parassitologia, 37, 149–193. PMid: 8778658. Google Scholar

  • [24] Pampiglione S., Rivasi F. 2000. Human dirofilariasis due to Dirofilaria (Nochtiella) repens: an update of world literature from 1995 to 2000. Parassitologia, 42, 231–254. PMid: 11686084. Google Scholar

  • [25] Pavlikovśka T., Nikolaênko S. 2011. [Current problems with vectorborne diseases]. Aktualńì problemi transmòsivnih parazitozìv. SES Profčlaktična Medicina, 4, 68–71 (In Ukrainian). Google Scholar

  • [26] Petropavlovskìj N.I. 1904. [Filaria immitis in the blood of dogs]. Arhiv “Veterinarnyh Nauk”, 34, 484–492 (In Russian). Google Scholar

  • [27] Popescu I., Tudose I., Racz P., Muntau B., Giurcaneanu C., Poppert S. 2012. Human Dirofilaria repens infection in Romania: a case report. Case Reports in Infectious Diseases, 2012, 472976. DOI: 10.1155/2012/472976. CrossrefGoogle Scholar

  • [28] Poppert S., Hodapp M., Krueger A., Hegasy G., Niesen W.D., Kern W.V., Tannich E. 2009. Dirofilaria repens infection and concomitant meningoencephalitis. Emerging Infectious Diseases, 15, 1844–1846. DOI: 10.3201/eid1511.090936. http://dx.doi.org/10.3201/eid1511.090936Web of ScienceCrossrefGoogle Scholar

  • [29] Prosvetova T.A, Melńičenko A.P. 1971. [Cases of human dirofilariasis in the Poltava region]. In: (Ed. V.Â. Podolan) Materialy po medicinskoj geografii levoberežnoj Ukrainy (Doklady na konferencii v oktabre 1969 g., Poltava). Leningrad, Geografičeskoe Obsestvo SSSR, pp. 118–119 (In Russian). Google Scholar

  • [30] Rozenbaum R.S. 1970. [A case of human dirofilariasis]. Medicinskaa Parazitologia i Parazitarnye Bolezni, 39, 620 (In Russian). PMid: 5511254. Google Scholar

  • [31] Sergiev V.P, Supraga V.G, Darčenkova N.N, Žukova L.A, Ivanova T.N. 2011. [Human dirofilariasis in Russia]. Rossijskij Parazitologičeskij Žurnal, 4, 60–64. Google Scholar

  • [32] Simón F., Siles-Lucas M., Morchón R., González-Miguel J., Mellado I., Carretón E., Montoya-Alonso J.A. 2012. Human and animal dirofilariasis: the emergence of a zoonotic mosaic. Clinical Microbiology Reviews, 2012, 25, 507–544. DOI: 10.1128/CMR.00012-12. http://dx.doi.org/10.1128/CMR.00012-12Web of ScienceCrossrefGoogle Scholar

  • [33] Skrabin K.I., Al’tgauzen Â.Â., Šul’man E.S. 1930. [First case of Dirofilaria repens in man]. Tropičeskaâ-Medicina i Veterinariâ, 8, 9–11 (In Russian). Google Scholar

  • [34] Šupik A.L., Sokova L.A., Prosvetova T.A. 1967. [A case of human dirofilariasis]. Medicinskaa Parazitologiâ i Parazitarnye Bolezni, 36, 239 (In Russian). PMid: 5618843. Google Scholar

  • [35] Suprâga V.G, Cybina T.N, Denisova T.N, Morozov E.N, Romanenko N.A, Starkova T.V. 2004. [The first case of diagnosis of dirofilariasis from the microfilariae detected in the human subcutaneous tumor punctate]. Medicinskaâ Parazitologiâ i Parazitarnye Bolezni, 4, 6–8 (In Russian). PMid: 15689127. Google Scholar

  • [36] Sušarnik A.S, Peremykin G.L. 1975. [Dirofilariasis of the eyelid]. Oftal’mologičeskij Žurnal, 30, 54–55 (In Russian). PMid: 1118118. Google Scholar

  • [37] Szénási Z., Kovács A.H., Pampiglione S., Fioravanti M.L., Kucsera I., Tánczos B., Tiszlavicz L. 2008. Human dirofilariosis in Hungary: an emerging zoonosis in central Europe. Wiener Klinische Wochenschrift, 120, 96–102. DOI: 10.1007/s00508-008-0928-2. http://dx.doi.org/10.1007/s00508-008-0928-2Web of ScienceCrossrefGoogle Scholar

  • [38] Žaboedov G.D., Šupik A.L. 1976. [Case of dirofilariasis of the eye in the Poltava region]. Oftal’mologičeskij Žurnal, 31, 467–468 (In Russian). PMid: 980362. Google Scholar

About the article

Published Online: 2013-12-13

Published in Print: 2013-12-01


Citation Information: Acta Parasitologica, Volume 58, Issue 4, Pages 592–598, ISSN (Online) 1896-1851, ISSN (Print) 1230-2821, DOI: https://doi.org/10.2478/s11686-013-0187-x.

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© 2013 W. Stefański Institute of Parasitology, PAS. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

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