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Acta Parasitologica

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Volume 60, Issue 1

Issues

Effect of structurally related flavonoids from Zuccagnia punctata Cav. on Caenorhabditis elegans

Romina E. D’Almeida / María R. Alberto
  • Corresponding author
  • INQUINOA (CONICET) San Lorenzo 1469. 4000. San Miguel de Tucumán, Argentina
  • Facultad de Ciencias Naturales e Instituto Miguel Lillo Universidad Nacional de Tucumán, San Lorenzo 1469. 4000. San Miguel de Tucumán, Argentina
  • Cátedra de Fitoquímica, Facultad de Bioquímica, Química y Farmacia Ayacucho 471. 4000. San Miguel de Tucumán, Argentina
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  • Other articles by this author:
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/ Phillip Morgan
  • Department of Anesthesiology, University of Washington and Children’s Research Institute, Seattle, WA 9810, USA
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/ Margaret Sedensky
  • Department of Anesthesiology, University of Washington and Children’s Research Institute, Seattle, WA 9810, USA
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/ María I. Isla
  • INQUINOA (CONICET) San Lorenzo 1469. 4000. San Miguel de Tucumán, Argentina
  • Facultad de Ciencias Naturales e Instituto Miguel Lillo Universidad Nacional de Tucumán, San Lorenzo 1469. 4000. San Miguel de Tucumán, Argentina
  • Cátedra de Fitoquímica, Facultad de Bioquímica, Química y Farmacia Ayacucho 471. 4000. San Miguel de Tucumán, Argentina;
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2014-12-30 | DOI: https://doi.org/10.1515/ap-2015-0023

Abstract

Zuccagnia punctata Cav. (Fabaceae), commonly called jarilla macho or pus-pus, is being used in traditional medicine as an antiseptic, anti-inflammatory and to relieve muscle and bone pain. The aim of this work was to study the anthelmintic effects of three structurally related flavonoids present in aerial parts of Z. punctata Cav. The biological activity of the flavonoids 7-hydroxyflavanone (HF), 3,7-dihydroxyflavone (DHF) and 2´,4´-dihydroxychalcone (DHC) was examined in the free-living nematode Caenorhabditis elegans. Our results showed that among the assayed flavonoids, only DHC showed an anthelmintic effect and alteration of egg hatching and larval development processes in C. elegans. DHC was able to kill 50% of adult nematodes at a concentration of 17 μg/mL. The effect on larval development was observed after 48 h in the presence of 25 and 50 μg/mL DHC, where 33.4 and 73.4% of nematodes remained in the L3 stage or younger. New therapeutic drugs with good efficacy against drug-resistant nematodes are urgently needed. Therefore, DHC, a natural compound present in Z. punctata, is proposed as a potential anthelmintic drug.

Keywords: 7-hydroxyflavanone; 3,7-dihydroxyflavone; 2´,4´-dihydroxychalcone; anthelmintic effect; Caenorhabditis elegans

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About the article

Received: 2014-04-30

Revised: 2014-10-17

Accepted: 2014-10-22

Published Online: 2014-12-30

Published in Print: 2014-03-01


Citation Information: Acta Parasitologica, Volume 60, Issue 1, Pages 164–172, ISSN (Online) 1896-1851, DOI: https://doi.org/10.1515/ap-2015-0023.

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