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Acta Parasitologica

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Volume 60, Issue 2


Antiparasitic DNA vaccines in 21st century

Halina Wedrychowicz
  • Corresponding author
  • Department of Molecular Biology, Laboratory of Molecular Parasitology, W. Stefański Institute Parasitology, Polish Academy of Sciences, 51/55 Twarda St., 00-818 Warsaw, Poland
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Published Online: 2015-03-25 | DOI: https://doi.org/10.1515/ap-2015-0026


Demands for effective vaccines to control parasitic diseases of humans and livestock have been recently exacerbated by the development of resistance of most pathogenic parasites to anti-parasitic drugs. Novel genomic and proteomic technologies have provided opportunities for the discovery and improvement of DNA vaccines which are relatively easy as well as cheap to fabricate and stable at room temperatures. However, their main limitation is rather poor immunogenicity, which makes it necessary to couple the antigens with adjuvant molecules. This paper review recent advances in the development of DNA vaccines to some pathogenic protozoa and helminths. Numerous studies were conducted over the past 14 years of 21st century, employing various administration techniques, adjuvants and new immunogenic antigens to increase efficacy of DNA vaccines. Unfortunately, the results have not been rewarding. Further research is necessary using more extensive combinations of antigens; alternate delivery systems and more efficient adjuvants based on knowledge of the immunomodulatory capacities of parasitic protozoa and helminths.

Keywords: DNA vaccines; adjuvants; exprimental trials; immunomodulation


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About the article

Received: 2014-12-14

Revised: 2014-12-15

Accepted: 2014-12-17

Published Online: 2015-03-25

Published in Print: 2015-06-01

Citation Information: Acta Parasitologica, Volume 60, Issue 2, Pages 179–189, ISSN (Online) 1896-1851, ISSN (Print) 1230-2821, DOI: https://doi.org/10.1515/ap-2015-0026.

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