Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Acta Parasitologica

4 Issues per year

IMPACT FACTOR 2016: 1.160
5-year IMPACT FACTOR: 1.185

CiteScore 2016: 1.24

SCImago Journal Rank (SJR) 2016: 0.532
Source Normalized Impact per Paper (SNIP) 2016: 0.721

See all formats and pricing
More options …
Volume 60, Issue 4


Association between immunoreactivity to Anisakis spp. antigens and high-risk pregnancy

Israel Figueiredo Jr
  • Corresponding author
  • Departamento Materno-Infantil, Faculdade de Medicina; Hospital Universitário Antônio Pedro, Universidade Federal Fluminense; Av. Marques do Paraná, 303; CEP: 24030-210, Centro, Niterói, Rio de Janeiro, Brasil
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Mauricio Vericimo / Luciana Terra
  • Departamento Tecnologia de Produtos de Origem Animal, Faculdade de Veterinária; Universidade Federal Fluminense, Brasil
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Taylane Ferreira / Sergio Carmona São Clemente
  • Departamento Tecnologia de Produtos de Origem Animal, Faculdade de Veterinária; Universidade Federal Fluminense, Brasil
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Gerlinde Teixeira
Published Online: 2015-09-25 | DOI: https://doi.org/10.1515/ap-2015-0085


Numerous factors contribute to perinatal risk, many of which remain undefined. This study sought to determine the frequency of fish intake in postpartum women, and to establish a relationship between the rates of immunoreactivity for antigens from Anisakis spp. and high-risk pregnancy. In this prospective noninterventional study, a structured questionnaire was administered and serum was collected from postpartum women at two perinatal centers (a high-risk birth unit [HRBU] and a low-risk birth unit [LRBU]) in the Niteroi municipality of Brazil. Anisakis species-specific IgG and IgE were measured by ELISA. The chisquared test was performed, and odds ratios (ORs) with their 95% confidence intervals were estimated. The t-test or Mann-Whitney test was applied to continuous, normally distributed variables. In total, 309 women (170 from HRBU, 139 from LRBU) between 24.8 and 26.7 years old with a median of 6 to 8 prenatal visits were enrolled. Women in the two units exhibited differences in some variables, including prenatal care (p = 0.01), maternal and fetal risk (p = 0.00; OR = 6.17), and gestational age (p = 0.00), but no differences in fish consumption (p = 0.29), frequency of fish intake (p = 0.40), allergic symptoms (p = 0.51), or frequency of anti-Anisakis reactivity (p = 0.22). Logistic regression analysis revealed that only age was independently associated with postpartum anti-Anisakis reactivity. This study confirmed a low prevalence of fish intake and suggested that Anisakis spp. had no impact on high-risk pregnancies among this postpartum study population.

Keywords: Anisakis spp.; fish; puerperium; ELISA


  • Abouzahr C. 2014. Progress and challenges in women’s health: an analysis of levels and patterns of mortality and morbidity. Contraception, DOI: 10.1016/j.contraception.2014.03.007PubMedCrossrefWeb of ScienceGoogle Scholar

  • Andriamandimbison Z., Randriambololona D.M., Rasoanandrianina B.S., Hery R.A. 2013. Causes of in utero fetal deaths: 225 cases at Befelatanana Hospital, Madagascar. Medecine et Sante Tropicales, 23, 78-82. DOI: 10.1684/mst.2013.0143CrossrefGoogle Scholar

  • Audicana M.T., Kennedy M.W. 2008. Anisakis simplex: from obscure infectious worm to inducer of immune hypersensitivity. Clinical Microbiological Reviews, 21, 360-379. DOI: 10.1128/ CMR.00012-07CrossrefGoogle Scholar

  • Boyon C., Collinet P., Boulanger L., Rubod C., Lucot J.P., Vinatier D. 2011. Fetal microchimerism: benevolence or malevolence for the mother? European Journal of Obstetrics & Gynecology and Reproductive Biology, 158, 148-152. DOI: 10. 1016/j.ejogrb.2011.05.008Web of ScienceCrossrefGoogle Scholar

  • Brasil. 2012 - Ministerio da Saude, Organizacao Pan-american da Saude. "Manual on neonatal IMCI: procedures." 3 ed. Retrieved 05/04, 2014, from http://bvsms.saude.gov.br/bvs/publicacoes/manual_aidpi_neonatal_3ed_2012.pdf Google Scholar

  • Buschmann C., Schmidbauer M., Tsokos M. 2013. Maternal and pregnancy-related death: causes and frequencies in an autopsy study population. Forensic Science, Medicine and Pathology, 9, 296-307. DOI: 10.1007/s12024-012-9401-7Web of ScienceCrossrefGoogle Scholar

  • Caballero M.L., Moneo I., Gomez-Aguado F., Corcuera M.T., Casado I., Rodriguez-Perez R. 2008. Isolation of Ani s 5, an excretorysecretory and highly heat-resistant allergen useful for the diagnosis of Anisakis larvae sensitization. Parasitology Research, 103, 1231-1233. DOI: 10.1007/s00436-008-1105-2Web of ScienceCrossrefGoogle Scholar

  • Corres L.F., Del Pozo M.D., Aizpuru F. 2001. Prevalence of Anisakis simplex sensitisation in three Spanish areas, in relation to the fish intake rates. Relevance of Anisakis simplex allergy. Alergología e Inmunología Clínica, 16, 337-346Google Scholar

  • Daschner A., Cuellar C., Rodero M. 2012. The Anisakis allergy debate: does an evolutionary approach help? Trends in Parasitology, 28, 9-15. DOI: 10.1016/j.pt.2011.10.001Web of ScienceCrossrefGoogle Scholar

  • Figueiredo Junior I., Vericimo M.A., Cardoso L.R., Sao Clemente S.C., do Nascimento E.R., Teixeira G.A. 2013. Cross-sectional study of serum reactivity to Anisakis simplex in healthy adults in Niteroi, Brazil. Acta Parasitologica, 58, 399-404. DOI: 10.2478/s11686-013-0157-3Web of ScienceCrossrefGoogle Scholar

  • Helgadottir L.B., Turowski G., Skjeldestad F.E., Jacobsen A.F., Sandset P.M., Roald B., Jacobsen E.M. 2013. Classification of stillbirths and risk factors by cause of death a case-control study. Acta Obstetricia et Gynecologica Scandinavica, 92, 325-333. DOI: 10.1111/aogs.12044Web of ScienceCrossrefGoogle Scholar

  • Joerink M., Rindsjo E., Stenius F., Alm J., Lilja G., Gronlund H., Scheynius A. 2009. Evidence for allergen-specific IgE of maternal origin in human placenta. Allergy, 64, 905-912. DOI: 10.1111/j.1398-9995.2009.01941.x CrossrefGoogle Scholar

  • Knoff M., Felizardo N.N., Iniguez A.M., Maldonado A., Jr., Torres E.J., Pinto R.M., Gomes D.C. 2012. Genetic and morphological characterisation of a new species of the genus Hysterothylacium (Nematoda) from Paralichthys isosceles Jordan, 1890 (Pisces: Teleostei) of the Neotropical Region, state of Rio de Janeiro, Brazil. Memórias do Instituto Oswaldo Cruz, 107, 186-193. DOI: S0074-02762012000200006Google Scholar

  • Knoff M., São Clemente S., Fonseca M., Andrada C., PadovaniI R., Gomes D. 2007. Anisakidae parasitos de congro-rosa, Genypterus brasiliensis Regan, 1903 comercializados no estado do Rio de Janeiro, Brasil de interesse na saude publica. Parasitología Latinoamericana, 62, 127-133 Google Scholar

  • Leventakou V., Roumeliotaki T., Martinez D., Barros H., Brantsaeter A.L., Casas M., Charles M.A., Cordier S., Eggesbo M., van Eijsden M., Forastiere F., Gehring U., Govarts E., Halldorsson T.I., Hanke W., Haugen M., Heppe D.H., Heude B., Inskip H.M., Jaddoe V.W., Jansen M., Kelleher C., Meltzer H.M., Merletti F., Molto-Puigmarti C., Mommers M., Murcia M., Oliveira A., Olsen S.F., Pele F., Polanska K., Porta D., Richiardi L., Robinson S.M., Stigum H., Strom M., Sunyer J., Thijs C., Viljoen K., Vrijkotte T.G., Wijga A.H., Kogevinas M., Vrijheid M., Chatzi L. 2014. Fish intake during pregnancy, fetal growth, and gestational length in 19 European birth cohort studies. The American Journal of Clinical Nutrition, 99, 506-516. DOI: 10.3945/ajcn.113.067421CrossrefGoogle Scholar

  • Lowry O.H., Rosebrough N.J., Farr A.L., Randll R.J. 1951. Protein Measurement with the Folin Phenol Reagent. The Journal of Biological Chemistry, 193, 265-275Google Scholar

  • Maria B. 2001. Maternal mortality: avoidable obstetrical complications. Journal de Gynécologie Obstétrique et Biologie de la Reproduction, 30, S23-32Google Scholar

  • Melo O., Ramos R., Di Beneditto A. 2006. Helminths of the marine tucuxi, Sotalia fluviatilis (Gervais, 1853) (Cetacea: Delphinidae), in northern Rio de Janeiro State, Brazil. Brazilian Archives of Biology and Technology, 49, DOI: 10.1590/ S1516-89132006000100017CrossrefGoogle Scholar

  • Mhyre J.M. 2012. Maternal mortality. Current Opinion in Anesthesiology, 25, 277-285. DOI: 10.1097/ACO.0b013e 3283530580CrossrefWeb of ScienceGoogle Scholar

  • Qin B., Plassman B.L., Edwards L.J., Popkin B.M., Adair L.S., Mendez M.A. 2014. Fish intake is associated with slower cognitive decline in Chinese older adults. Journal of Nutrition, DOI: 10.3945/jn.114.193854CrossrefGoogle Scholar

  • Renou C., Pariente A., Roque-Afonso A.M., Nicand E. 2012. Autochthonous hepatitis E: an emerging and still unrecognized disease. La Revue du Praticien, 62, 903-908Google Scholar

  • Rowe J.M.K.M., Barbara J. Holt, Devinda Suriyaarachchi BSc(Hons), Michael Serralha (Hons), Elysia Hollams, Stephanie T. Yerkovich, Lily S. Subrata, Claire Ladyman, Agata Sadowska, Jamie Gillett, Elizabeth Fisher, Richard Loh FRACP, Lars Soderstrom, Staffan Ahlstedt, Peter D. Sly, FRACP and Patrick G. Holt 2007. Prenatal versus postnatal sensitization to environmental allergens in a high-risk birth cohort Journal of Allergy and Clinical Immunology, 119, 1164-1173Web of ScienceGoogle Scholar

  • Shah S.a.B.M. 2009. Cord Serum Screening Test and the Newborn’s Allergic Status. Indian Pediatrics, 46, 295-299Google Scholar

  • Shapiro-Mendoza C.K., Lackritz E.M. 2012. Epidemiology of late and moderate preterm birth. Seminars in Fetal and Neonatal Medicine, 17, 120-125. DOI: 10.1016/j.siny.2012.01.007CrossrefWeb of ScienceGoogle Scholar

  • Stingone J.A., Luben T.J., Daniels J.L., Fuentes M., Richardson D.B., Aylsworth A.S., Herring A.H., Anderka M., Botto L., Correa A., Gilboa S.M., Langlois P.H., Mosley B., Shaw G.M., Siffel C., Olshan A.F. 2014. Maternal Exposure to Criteria Air Pollutants and Congenital Heart Defects in Offspring: Results from the National Birth Defects Prevention Study. Environmental Health Perspectives, DOI: 10.1289/ehp.1307289Web of ScienceCrossrefGoogle Scholar

  • Zaribaf F., Falahi E., Barak F., Heidari M., Keshteli A.H., Yazdannik A., Esmaillzadeh A. 2014. Fish consumption is inversely associated with the metabolic syndrome. European Journal of Clinical Nutrition, 68, 474-480. DOI: 10.1038/ejcn.2014.5 CrossrefGoogle Scholar

About the article

Received: 2014-09-12

Revised: 2015-03-20

Accepted: 2015-04-28

Published Online: 2015-09-25

Published in Print: 2015-12-01

Citation Information: Acta Parasitologica, Volume 60, Issue 4, Pages 609–613, ISSN (Online) 1896-1851, ISSN (Print) 1230-2821, DOI: https://doi.org/10.1515/ap-2015-0085.

Export Citation

W. Stefański Institute of Parasitology, PAS. Copyright Clearance Center

Comments (0)

Please log in or register to comment.
Log in