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Acta Parasitologica

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Volume 60, Issue 4 (Dec 2015)

Issues

Malondialdehyde; Lipid peroxidation plasma biomarker correlated with hepatic fibrosis in human Schistosoma mansoni infection

Inas Abdel Aziz
  • Corresponding author
  • Faculty of Medicine, Cairo University Kasr AlAiny street, Kasr AlAiny School of Medicine, Cairo University Hospitals, Cairo, 11562, Egypt. Departments: Medical Parasitology
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  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Mariam Yacoub
  • Faculty of Medicine, Cairo University Kasr AlAiny street, Kasr AlAiny School of Medicine, Cairo University Hospitals, Cairo, 11562, Egypt. Departments: Clinical & Chemical Pathology
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Laila Rashid
  • Faculty of Medicine, Cairo University Kasr AlAiny street, Kasr AlAiny School of Medicine, Cairo University Hospitals, Cairo, 11562, Egypt. Departments: Medical Biochemistry
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Ahmad Solieman
  • Faculty of Medicine, Cairo University Kasr AlAiny street, Kasr AlAiny School of Medicine, Cairo University Hospitals, Cairo, 11562, Egypt. Departments: Tropical Medicine
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2015-09-25 | DOI: https://doi.org/10.1515/ap-2015-0105

Abstract

Schistosomiasis is a debilitating parasitic disease, affects large number of host species. Currently affects 250-300 million people in tropic areas. Schistosoma pathogenic impact is hepatic periportal fibrosis; the parasite-induced inflammatory cellular activation promotes oxidative stress, resulting in lipid peroxidation (LPO), with subsequent increase in inflammatory mediators as malondialdehyde (MDA). This study was set up to reveal possible contribution of lipid peroxidation byproducts MDA in hepatic pathophysiology. Results displayed that MDA don’t tend to change in relation with either age, nor hepatic transaminases AST & ALT, while exhibited a significant increase in MDA levels in human schistosomiasis versus control group P<0.0001 (Mn. ± St.dev. 7.77 ± 3.59, 1.21 ± 0.28 nmol/ml) respectively. Moreover; MDA plasma levels in Schistosoma infected group correlated significantly with two hepatic fibrosis parameters; (a) ultrasonography graded periportal fibrosis P< 0.0001. Levels of MDA in hepatic fibrosis grades 0, I, II, III in Schistosoma infected group were (Mn. ± St.dev. 2.8 ± 0.64, 4.3 ± 1.2, 9.3 ± 1.6 and 10.8 ± 1.3 nmol/ml) respectively, (b) serum Hyaluronic acid (HA) P<0.0001 (spearman r = 0.77) as a reliable hepatic fibrosis marker. This implies a considerable role of LPO byproducts in schistosomiasis pathogenicity, and proposing malondialdehyde as a biomarker for schistosomiasis morbidity.

Keywords: Lipid peroxidation; Malondialdehyd; Schistosoma mansoni; Hyaluronic acid

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About the article

Received: 2014-12-13

Revised: 2015-05-29

Accepted: 2015-06-01

Published Online: 2015-09-25

Published in Print: 2015-12-01


Citation Information: Acta Parasitologica, ISSN (Online) 1896-1851, ISSN (Print) 1230-2821, DOI: https://doi.org/10.1515/ap-2015-0105.

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