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Acta Parasitologica

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IMPACT FACTOR 2017: 1.039
5-year IMPACT FACTOR: 1.121

CiteScore 2017: 1.17

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1896-1851
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Volume 62, Issue 4

Issues

Comparative analysis of codon usage pattern and its influencing factors in Schistosoma japonicum and Ascaris suum

Gulshana A. Mazumder / Arif Uddin / Supriyo Chakraborty
Published Online: 2017-10-15 | DOI: https://doi.org/10.1515/ap-2017-0090

Abstract

Schistosoma japonicum and Ascaris suum are considered as the major parasites of human which cause various life threatening diseases such as schistomiasis and ascariasis. The codon usage bias (CUB) is known as the phenomenon of more usage of a specific codon than the other synonymous codons for an amino acid. The factors that influence the codon usage bias are mutation pressure, natural selection, gene expression, gene length, GC content, RNA stability, recombination rates, codon position etc. Here we had used various bioinformatic tools and statistical analyses to understand the compositional features, expression level and codon usage bias in the genes of these two species.After estimating the effective number of codon (ENC) in both the species, codon usage bias was found to be low and gene expression was high. The nucleobase A and T were used most often than C and G. From neutrality plot and correspondence analysis it was found that both natural selection and mutation pressure played an important role in shaping the codon usage pattern of both species. Moreover, natural selection played a major role while mutation pressure played a minor role in shaping the codon usage bias in S. japonicum and A.suum. This is the first report on the codon usage biology in S. japonicum and A.suum, and the factors influencing their codon usage bias. These results are expected to be useful for genetic engineering and evolutionary studies.

Keywords: Schistosoma japonicum; Ascaris suum; codon usage bias; compositional properties; expression level; neutrality plot

Reference

About the article

Received: 2017-02-04

Revised: 2017-07-20

Accepted: 2017-07-21

Published Online: 2017-10-15

Published in Print: 2017-12-20


Conflict of interest: There is no conflict of interest in this research work.


Citation Information: Acta Parasitologica, Volume 62, Issue 4, Pages 748–761, ISSN (Online) 1896-1851, ISSN (Print) 1230-2821, DOI: https://doi.org/10.1515/ap-2017-0090.

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[1]
Gulshana A Mazumder, Arif Uddin, and Supriyo Chakraborty
Molecular and Biochemical Parasitology, 2018
[2]
Lucas L. Maldonado, Georgina Stegmayer, Diego H. Milone, Guilherme Oliveira, Mara Rosenzvit, and Laura Kamenetzky
Molecular and Biochemical Parasitology, 2018

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