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Acta Parasitologica

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Volume 63, Issue 1

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A serological study of antibodies to Anaplasma phagocytophilum and Borrelia burgdorferi sensu lato in the sera of healthy individuals collected two decades apart

Bohumír Kříž
  • National Institute of Public Health, Šrobárova 48, 100 42 Praha 10, Czech Republic
  • Charles University, 3rd Medical Faculty, Ruská 87, 100 00 Praha 10, Czech Republic
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Marek Malý / Pavla Balátová / Petr Kodym / Zuzana Kurzová / Milan Daniel / Kateřina Kybicová
Published Online: 2018-01-17 | DOI: https://doi.org/10.1515/ap-2018-0004

Abstract

Sera collected from healthy individuals from the general population in the Czech Republic during repeated cross-sectional surveys were analyzed. Samples collected in the same six districts in two time periods, 1978-1989 and 2001, were compared. The study subjects were divided into six age categories between 10 and 59 years. Overall, 434 samples from 1978-1989 and 270 samples from 2001 were screened for Anaplasma phagocytophilum (AP) and Borrelia burgdorferi sensu lato (BB). The anti-AP positivity rates were 13.1% and 11.5% in the first and second period, respectively, and did not differ significantly between the periods (P = 0.559). The anti-BB antibodies were detected in 33.9% and 14.8% of study subjects, respectively. The positivity rates were significantly lower in the second period (P<0.001). No considerable changes were observed in the sex distribution of positive findings between the two periods. The highest positivity rates of anti-AP antibodies were found in the 10–14 year age group: 16.0% in 1978-1989 and 16.7% in 2001. The age distribution of the anti-AP antibody positivity rates did not change substantially (P = 0.872). In 1978-1989, the lowest anti-BB antibody positivity rate (26.7%) was found in the 10–14 year age group, with a gradual increase with age to 41.1% in 50–59 year-olds. In 2001, the positivity rate in the 10–14 year age group was 26.2% and was not significantly different from that in the first period (P = 0.955). However, the positivity rates in the older age groups 15–59 years decreased significantly (P<0.001) and varied between 8.3% and 15.1%.

Keywords: Borrelia burgdorferi; Anaplasma; antibodies; distribution; epidemiology

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About the article

Received: 2016-09-06

Revised: 2017-09-19

Accepted: 2017-09-21

Published Online: 2018-01-17

Published in Print: 2018-03-26


Author Disclosure Statement: The authors declare that they have no competing interests.


Citation Information: Acta Parasitologica, Volume 63, Issue 1, Pages 33–39, ISSN (Online) 1896-1851, ISSN (Print) 1230-2821, DOI: https://doi.org/10.1515/ap-2018-0004.

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