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Bio-Algorithms and Med-Systems

Editor-in-Chief: Roterman-Konieczna , Irena


CiteScore 2018: 0.29

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Structure of hydrophobic core in plant carboxylesterase

Mateusz Banach
  • Department of Bioinformatics and Telemedicine, Jagiellonian University Medical College, Krakow, Poland
  • Other articles by this author:
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/ Leszek Konieczny
  • Department of Bioinformatics and Telemedicine, Jagiellonian University Medical College, Krakow, Poland
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Zdzisław Wiśniowski
  • Department of Bioinformatics and Telemedicine, Jagiellonian University Medical College, Krakow, Poland
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/ Irena Roterman
  • Corresponding author
  • Department of Bioinformatics and Telemedicine, Jagiellonian University Medical College, Lazarza 16, 31-530 Krakow, Poland
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Published Online: 2017-02-21 | DOI: https://doi.org/10.1515/bams-2017-0001

Abstract

The fuzzy oil drop model was applied to characterize the hydrophobic core structure in plant carboxylesterase. The characteristics revealed the status of β-sheets in the central part of the molecule as discordant as opposed to the expected hydrophobicity distribution. Particularly, the β-strands and helices in close proximity to the enzymatic residues recognized as discordant with respect to the ideal hydrophobicity distribution of hydrophobic core are of high importance. It is assumed that this local irregularity is the form of coding the specificity of enzymes. The protein under consideration appears to be the next example proving this assumption.

Keywords: carboxylesterase; fuzzy oil drop model; hydrolase; hydrophobicity

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About the article

Received: 2017-01-03

Accepted: 2017-01-26

Published Online: 2017-02-21

Published in Print: 2017-03-01


Author contributions: The authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

Research funding: The work was financially supported by the Jagiellonian University Medical College (grant K/ZDS/006363).

Employment or leadership: None declared.

Honorarium: None declared.

Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.


Citation Information: Bio-Algorithms and Med-Systems, Volume 13, Issue 1, Pages 13–16, ISSN (Online) 1896-530X, ISSN (Print) 1895-9091, DOI: https://doi.org/10.1515/bams-2017-0001.

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