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Bio-Algorithms and Med-Systems

Editor-in-Chief: Roterman-Konieczna , Irena


CiteScore 2017: 0.43

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1896-530X
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Phylogenetic and variability study on all known hemagglutinin subtypes of influenza A virus

Rafał Filip
  • Corresponding author
  • Department of Molecular Biology, Faculty of Biological Sciences, University of Zielona Góra, Zielona Góra, Poland
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  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Jacek Leluk
  • Department of Molecular Biology, Faculty of Biological Sciences, University of Zielona Góra, Zielona Góra, Poland
  • Other articles by this author:
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Published Online: 2017-06-13 | DOI: https://doi.org/10.1515/bams-2017-0009

Abstract

Hemagglutinin (HA) is a surface glycoprotein found in influenza viruses. This particle plays two crucial functions in the viral life cycle: it allows for the attachment of the virus into the host cell and participates in the fusion of the virus and host membranes. There are 18 different subtypes of HA. Recently, the H17 and H18 strains have been discovered whose hosts were bats. The evolution of these two strains had most likely occurred in isolation for a long period of time. This work presents the phylogenetic analysis and study on mutational variability based on sequences from all 18 currently known HA strains belonging to influenza virus type A. The results have been presented regarding the current knowledge about influenza. The classical software (Clustal, PHYLIP, and ConSurf) as well as original applications (SSSSg and Consensus Constructor) have been used in this research.

This article offers supplementary material which is provided at the end of the article.

Keywords: hemagglutinin (HA); influenza A virus; phylogenesis of HA influenza; variability of HA

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About the article

Received: 2017-03-27

Accepted: 2017-05-18

Published Online: 2017-06-13

Published in Print: 2017-09-26


Author contributions: The authors accept responsibility for the entire content of this article and approved its submission.

Research funding: None declared.

Employment or leadership: None declared.

Honorarium: None declared.

Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.


Citation Information: Bio-Algorithms and Med-Systems, Volume 13, Issue 3, Pages 153–159, ISSN (Online) 1896-530X, ISSN (Print) 1895-9091, DOI: https://doi.org/10.1515/bams-2017-0009.

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