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Bio-Algorithms and Med-Systems

Editor-in-Chief: Roterman-Konieczna , Irena


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Chain-chain complexation and heme binding in haemoglobin with respect to the hydrophobic core structure

Magdalena Ptak
  • Department of Bioinformatics and Telemedicine, Jagiellonian University Medical College, Krakow, Poland
  • Faculty of Physics, Astronomy and Applied Computer Scienceinstitution, Jagiellonian University, Krakow, Poland
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Mateusz Banach
  • Department of Bioinformatics and Telemedicine, Jagiellonian University Medical College, Krakow, Poland
  • Faculty of Physics, Astronomy and Applied Computer Scienceinstitution, Jagiellonian University, Krakow, Poland
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Zdzisław Wiśniowski
  • Department of Bioinformatics and Telemedicine, Jagiellonian University Medical College, Krakow, Poland
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  • De Gruyter OnlineGoogle Scholar
/ Leszek Konieczny / Irena Roterman
  • Corresponding author
  • Department of Bioinformatics and Telemedicine, Jagiellonian University Medical College, Krakow, Poland
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Published Online: 2017-12-23 | DOI: https://doi.org/10.1515/bams-2017-0024

Abstract

Heme binding by proteins and protein-protein complexation are the processes strongly related to the biological activity of proteins. The mechanism of these processes has not been still recognised. These phenomena are presented using haemoglobin as the example. Half of the mature haemoglobin (one α-chain and one β-chain) treated as a dissociation step in haemoglobin degradation reveals a specific change in heme binding after dissociation. This phenomenon is the object of analysis that interprets the structure of both complexes (tetramer and dimer) with respect to their hydrophobic core structure. The results suggest the higher stability of the complex in the form of one α-chain and one β-chain with respect to the hydrophobic core.

Keywords: heme binding; hydrophobicity; protein folding; protein-protein complexation; tertiary structure

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About the article

Received: 2017-10-30

Accepted: 2017-11-22

Published Online: 2017-12-23

Published in Print: 2017-12-20


Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

Research funding: The work was financially supported by Jagiellonian University Medical College (Funder Id: 10.13039/100009045, grant systems K/ZDS/006363 and K/ZDS/006366).

Employment or leadership: None declared.

Honorarium: None declared.

Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.


Citation Information: Bio-Algorithms and Med-Systems, Volume 13, Issue 4, Pages 179–185, ISSN (Online) 1896-530X, ISSN (Print) 1895-9091, DOI: https://doi.org/10.1515/bams-2017-0024.

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