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Bio-Algorithms and Med-Systems

Editor-in-Chief: Roterman-Konieczna , Irena


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Aggregation-promoting conditions necessary to create the complexes by acylphosphatase from the hyperthermophile Sulfolobus solfataricus

Mateusz Banach
  • Department of Bioinformatics and Telemedicine, Jagiellonian University Medical College, Krakow, Poland
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/ Zdzisław Wiśniowski
  • Corresponding author
  • Department of Bioinformatics and Telemedicine, Jagiellonian University Medical College, Lazarza 16, 31-530 Krakow, Poland
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/ Magdalena Ptak
  • Department of Bioinformatics and Telemedicine, Jagiellonian University Medical College, Krakow, Poland
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/ Irena Roterman
  • Department of Bioinformatics and Telemedicine, Jagiellonian University Medical College, Krakow, Poland
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Published Online: 2019-07-04 | DOI: https://doi.org/10.1515/bams-2019-0023

Abstract

The structural transition from the globular to the amyloid form of proteins requires aggregation-promoting conditions. The protein example of this category is acylphosphatase from the hyperthermophile Sulfolobus solfataricus. This protein represents a structure with a well-defined hydrophobic core. This is why the complexation (including oligomerization) of this protein is of low probability. The chain fragment participating in aggregation in comparison to the status with respect to the fuzzy oil drop model is discussed in this paper.

Keywords: aggregation-promoting conditions; amyloidosis; hydrophobicity

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About the article

Received: 2019-05-15

Accepted: 2019-06-04

Published Online: 2019-07-04


Funding Source: Jagiellonian University Medical College grant systems

Award identifier / Grant number: K/ZDS/006363

The work was financially supported by the Jagiellonian University Medical College grant systems (Funder Id: http://dx.doi.org/10.13039/100009045, grant no. K/ZDS/006363).


Ethical Approval: The conducted research is not related to either human or animal use.

Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

Employment or leadership: None declared.

Honorarium: None declared.

Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

Conflict of interests: The authors declare no conflict of interest.


Citation Information: Bio-Algorithms and Med-Systems, Volume 15, Issue 2, 20190023, ISSN (Online) 1896-530X, DOI: https://doi.org/10.1515/bams-2019-0023.

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