Jump to ContentJump to Main Navigation
Show Summary Details

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred

12 Issues per year


IMPACT FACTOR 2015: 2.710
Rank 142 out of 289 in category Biochemistry & Molecular Biology in the 2015 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2015: 1.607
Source Normalized Impact per Paper (SNIP) 2015: 0.751
Impact per Publication (IPP) 2015: 2.609

Online
ISSN
1437-4315
See all formats and pricing
Volume 380, Issue 10 (Oct 1999)

Issues

The T-Knot Motif Revisited

Fabio Polticelli / Stefano Pascarella / Domenico Bordo / Martino Bolognesi / Paolo Ascenzi
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/BC.1999.159

Abstract

The T-knot scaffold, a disulphide-reinforced structural motif shared by several proteins with very different biological functions, has been defined as ‘a stretch of the protein chain which comprises two strands of a β-sheet and three loops, knotted by two disulphides into the shape of the letter T’. In this communication we show that the presence of a central β-sheet is not a required structural feature for proteins sharing the T-knot topology. Moreover, superposition of the three-dimensional structures of representative members of the T-knot family highlights a common and structurally well-defined core, formed by the two knotted disulphides, substituting for a larger residue-based hydrophobic core. These results suggest that folding and stability of the T-knot scaffold mainly depend on the geometry of the two knotted disulphides and on the loop length, and that the secondary structure elements are not a prerequisite for motif formation. Accordingly, a redefinition of the T-knot motif is proposed.

About the article

Published Online: 2005-06-01

Published in Print: 1999-10-12


Citation Information: Biological Chemistry, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.1999.159. Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
F Polticelli
Biochemistry and Molecular Biology Education, 2001, Volume 29, Number 1, Page 16
[2]
Carlos González, José Luis Neira, Salvador Ventura, Silvia Bronsoms, Manuel Rico, and Francese X. Avilés
Proteins: Structure, Function, and Bioinformatics, 2003, Volume 50, Number 3, Page 410
[4]
Fabio Polticelli, Gabriella Raybaudi-Massilia, and Paolo Ascenzi
Biochemistry and Molecular Biology Education, 2001, Volume 29, Number 1, Page 16

Comments (0)

Please log in or register to comment.
Log in