Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

12 Issues per year

IMPACT FACTOR 2016: 3.273

CiteScore 2016: 3.01

SCImago Journal Rank (SJR) 2016: 1.679
Source Normalized Impact per Paper (SNIP) 2016: 0.800

See all formats and pricing
More options …
Volume 380, Issue 2 (Feb 1999)


The Functions of Breast Cancer Susceptibility Gene 1 (BRCA1) Product and Its Associated Proteins

I. Irminger-Finger / B.D. Siegel / W.-C. Leung
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/BC.1999.019


About half of the familial breast cancer cases are found to bear mutations in the breast cancer susceptibility gene 1 (BRCA1). The majority of BRCA1 mutations produce a truncated protein and BRCA1-associated breast tumors exhibit a number of defined tumor phenotypes. The function of BRCA1 has been examined in gene knockout mice in which the nullizygous mice die early in utero, but this lethality can be partially rescued by a nullizygous p53 mutation. Wild-type BRCA1 protein binds to a number of cellular proteins, including DNA repair protein Rad51, tumor suppressor p53, RNA polymerase II holoenzyme, RNA helicase A, CtBP-interacting protein, c-myc, BRCA1-associated RING domain protein (BARD1), BRCA2 protein, etc. These proteins likely mediate the involvement of BRCA1 in DNA repair, transcriptional transactivation, and cell cycle control. Overall, BRCA1 protein may act as a converging vehicle for cell regulatory proteins to associate with. Therefore, mutations in BRCA1 may affect the composition of these complexes on which dysregulation of cellular functions with eventual development of malignancy is expected.

About the article

Published Online: 2005-06-01

Published in Print: 1999-02-01

Citation Information: Biological Chemistry, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.1999.019.

Export Citation

Copyright © 1999 by Walter de Gruyter GmbH & Co. KG. Copyright Clearance Center

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Timothy K. MacLachlan, Bipin C. Dash, David T. Dicker, and Wafik S. El-Deiry
Journal of Biological Chemistry, 2000, Volume 275, Number 41, Page 31869
Alfonso Urbanucci, Kati K Waltering, Hanna E Suikki, Merja A Helenius, and Tapio Visakorpi
BMC Cancer, 2008, Volume 8, Number 1
Averell Gnatt
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 2002, Volume 1577, Number 2, Page 175
F. Duarte, J.F. Cameselle-Teijeiro, R. Soares, C. Seixas, J. Pérez-Villanueva, F.C. Schmitt, and M.E. Cortizo-Torres
Revista Clínica Española, 2002, Volume 202, Number 5, Page 259
Hongzhuang Peng, Gillian E Begg, David C Schultz, Josh R Friedman, David E Jensen, David W Speicher, and Frank J Rauscher
Journal of Molecular Biology, 2000, Volume 295, Number 5, Page 1139
Trevor Leong, Jonathan Whitty, Michelle Keilar, Sharon Mifsud, Jonathan Ramsay, Geoffrey Birrell, Deon Venter, Melissa Southey, and Michael McKay
International Journal of Radiation Oncology*Biology*Physics, 2000, Volume 48, Number 4, Page 959
Daniel J. Satterwhite, Nori Matsunami, and Raymond L. White
Biochemical and Biophysical Research Communications, 2000, Volume 276, Number 2, Page 686
Yinghua Chen, Stanley Borowicz, James Fackenthal, Frank R. Collart, Elizabeth Myatt, Shiu Moy, Gyorgy Babnigg, Rosemarie Wilton, William E. Boernke, Marianne Schiffer, Fred J. Stevens, and Olufunmilayo I. Olopade
Biochemical and Biophysical Research Communications, 2006, Volume 345, Number 1, Page 188
Jaime Prat, Adriana Ribé, and Alberto Gallardo
Human Pathology, 2005, Volume 36, Number 8, Page 861
Ralph Scully and Nadine Puget
Biochimie, 2002, Volume 84, Number 1, Page 95
Irmgard Irminger-Finger and Wai-Choi Leung
The International Journal of Biochemistry & Cell Biology, 2002, Volume 34, Number 6, Page 582
L Aravind and G Subramanian
Current Opinion in Genetics & Development, 1999, Volume 9, Number 6, Page 688
Ben Goertzel, Cassio Pennachin, Maurício de Alvarenga Mudado, and Lúcio de Souza Coelho
Rejuvenation Research, 2008, Volume 11, Number 4, Page 735
Ivo Cristiano Martins, Inna Kuperstein, Hannah Wilkinson, Elke Maes, Mieke Vanbrabant, Wim Jonckheere, Patrick Van Gelder, Dieter Hartmann, Rudi D'Hooge, Bart De Strooper, Joost Schymkowitz, and Frederic Rousseau
The EMBO Journal, 2008, Volume 27, Number 1, Page 224
K. A. Phillips
Internal Medicine Journal, 2001, Volume 31, Number 6, Page 349
Pierre O. Chappuis, Victoria Nethercot, and William D. Foulkes
Seminars in Surgical Oncology, 2000, Volume 18, Number 4, Page 287
F. Stefania Falvella, Elena Menegola, Erminio Giavini, Michelle Ottey, Vincenzo Fidanza, Carlo M. Croce, Kay Huebner, and Tommaso A. Dragani
The Anatomical Record, 2000, Volume 260, Number 2, Page 208
P. LouAnn Cable, Cindy A. Wilson, Frank J. Calzone, Frank J. Rauscher, Ralph Scully, David M. Livingston, Leping Li, Courtney B. Blackwell, P. Andrew Futreal, and Cynthia A. Afshari
Molecular Carcinogenesis, 2003, Volume 38, Number 2, Page 85

Comments (0)

Please log in or register to comment.
Log in