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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred


IMPACT FACTOR 2018: 3.014
5-year IMPACT FACTOR: 3.162

CiteScore 2018: 3.09

SCImago Journal Rank (SJR) 2018: 1.482
Source Normalized Impact per Paper (SNIP) 2018: 0.820

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1437-4315
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Volume 380, Issue 3

Issues

The Core Antigen of Hepatitis B Virus as a Carrier for Immunogenic Peptides

K. Murray / A.-L. Shiau
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/BC.1999.038

Abstract

The core antigen of hepatitis B virus (HBcAg) made in Escherichia coli yields particles that closely resemble the viral nucleocapsid. Extensive modifications can be made to the primary structure of HBcAg without impairing particle assembly. This enables other peptide sequences, including very long sequences, to be added, substituted, or inserted into the nucleocapsid subunit while retaining the ability to form highly immunogenic particles. These also retain the T cell epitopes of HBcAg and constitute powerful delivery systems for a diverse range of immunogenic epitopes and have significant potential for development of multicomponent vaccines.

About the article

Published Online: 2005-06-01

Published in Print: 1999-03-01


Citation Information: Biological Chemistry, Volume 380, Issue 3, Pages 277–283, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.1999.038.

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