Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

IMPACT FACTOR 2017: 3.022

CiteScore 2017: 2.81

SCImago Journal Rank (SJR) 2017: 1.562
Source Normalized Impact per Paper (SNIP) 2017: 0.705

See all formats and pricing
More options …
Volume 380, Issue 3


Ty Virus-Like Particles, DNA Vaccines and Modified Vaccinia Virus Ankara; Comparisons and Combinations

S. C. Gilbert / J. Schneider / M. Plebanski / C. M. Hannan / G. L. Smith T. J. Blanchard / A. V. S. Hill
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/BC.1999.041


Three types of vaccine, all expressing the same antigen from Plasmodium berghei, or a CD8+ T cell epitope from that antigen, were compared for their ability to induce CD8+ T cell responses in mice. Higher levels of lysis and numbers of IFN-γ secreting T cells were primed with Ty virus-like particles and Modified Vaccinia Virus Ankara (MVA) than with DNA vaccines, but none of the vaccines were able to protect immunised mice from infectious challenge even after repeated doses. However, when the immune response was primed with one type of vaccine (Ty-VLPs or DNA) and boosted with another (MVA) complete protection against infection was achieved. Protection correlated with very high levels of IFN-γ secreting T cells and lysis. This method of vaccination uses delivery systems and routes that can be used in humans and could provide a generally applicable regime for the induction of high levels of CD8+ T cells.

About the article

Published Online: 2005-06-01

Published in Print: 1999-03-01

Citation Information: Biological Chemistry, Volume 380, Issue 3, Pages 299–303, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.1999.041.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Vasee Moorthy and Adrian V S Hill
British Medical Bulletin, 2002, Volume 62, Number 1, Page 59
D. Lys Guilbride, Pawel Gawlinski, Patrick D. L. Guilbride, and Mauricio Martins Rodrigues
PLoS ONE, 2010, Volume 5, Number 5, Page e10685
Cheng-Tao Lin, Chien-Fu Hung, Jeremy Juang, Liangmei He, Ken-Yu Lin, Tae WooKim, and T.-C. Wu
Molecular Therapy, 2003, Volume 8, Number 4, Page 559
Sharmila Manoj, Lorne A. Babiuk, and Sylvia den Hurk
Critical Reviews in Clinical Laboratory Sciences, 2004, Volume 41, Number 1, Page 1
Sarah Sebastian and Sarah C. Gilbert
Expert Review of Vaccines, 2016, Volume 15, Number 1, Page 91
Elizabeth M Adams and Lawrence M Fox
Clinical and Applied Immunology Reviews, 2000, Volume 1, Number 2, Page 73
Beatrice O. Ondondo
Frontiers in Microbiology, 2014, Volume 5
Sarah C. Gilbert
Vaccine, 2013, Volume 31, Number 39, Page 4241
Parasite Immunology, 2011, Volume 33, Number 11, Page 594
Sarah C Gilbert, Jörg Schneider, Carolyn M Hannan, Jiang Ting Hu, Magdalena Plebanski, Robert Sinden, and Adrian V.S Hill
Vaccine, 2002, Volume 20, Number 7-8, Page 1039
Chien-Hung Chen, Tian-Li Wang, Chien.-Fu Hung, Drew M Pardoll, and T.-C Wu
Vaccine, 2000, Volume 18, Number 19, Page 2015
Denise L Doolan and Stephen L Hoffman
International Journal for Parasitology, 2001, Volume 31, Number 8, Page 753
Vasee S Moorthy, Egeruan B Imoukhuede, Paul Milligan, Kalifa Bojang, Sheila Keating, Pauline Kaye, Margaret Pinder, Sarah C Gilbert, Gijs Walraven, Brian M Greenwood, Adrian S. V Hill, and Davy Koech
PLoS Medicine, 2004, Volume 1, Number 2, Page e33
Parasite Immunology, 2006, Volume 28, Number 1-2, Page 15
Ian FC McKenzie, Vasso Apostolopoulos, Magdalena Plebanski, Geoffrey A Pietersz, and Bruce E Loveland
Immunology and Cell Biology, 2003, Volume 81, Number 1, Page 79

Comments (0)

Please log in or register to comment.
Log in