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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

12 Issues per year

IMPACT FACTOR 2016: 3.273

CiteScore 2016: 3.01

SCImago Journal Rank (SJR) 2016: 1.679
Source Normalized Impact per Paper (SNIP) 2016: 0.800

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Volume 380, Issue 5


Biosynthesis of Glycosylphosphatidylinositols in Mammals and Unicellular Microbes

A. Tiede / I. Bastisch / J. Schubert / P. Orlean / R. E. Schmidt
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/BC.1999.066


Membrane anchoring of cell surface proteins via glycosylphosphatidylinositol (GPI) occurs in all eukaryotic organisms. In addition, GPI-related glycophospholipids are important constituents of the glycan coat of certain protozoa. Defects in GPI biosynthesis can retard, if not abolish growth of these organisms. In humans, a defect in GPI biosynthesis can cause paroxysmal nocturnal hemoglobinuria (PNH), a severe acquired bone marrow disorder. Here, we review advances in the characterization of GPI biosynthesis in parasitic protozoa, yeast and mammalian cells. The GPI core structure as well as the major steps in its biosynthesis are conserved throughout evolution. However, there are significant biosynthetic differences between mammals and microbes. First indications are that these differences could be exploited as targets in the design of novel pharmacotherapeuticsthat selectively inhibit GPI biosynthesis in unicellular microbes.

About the article

Published Online: 2005-06-01

Published in Print: 1999-05-03

Citation Information: Biological Chemistry, Volume 380, Issue 5, Pages 503–524, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.1999.066.

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