Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred


IMPACT FACTOR 2018: 3.014
5-year IMPACT FACTOR: 3.162

CiteScore 2018: 3.09

SCImago Journal Rank (SJR) 2018: 1.482
Source Normalized Impact per Paper (SNIP) 2018: 0.820

Online
ISSN
1437-4315
See all formats and pricing
More options …
Volume 380, Issue 7-8

Issues

A Unified Mechanism of Enzymatic Synthesis of Two Calcium Messengers: Cyclic ADP-Ribose and NAADP

H. C. Lee
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/BC.1999.098

Abstract

Cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP) mobilize Ca2+ from two different types of intracellular stores and through completely independent mechanisms. The two Ca2+ messengers are also structurally distinct. cADPR is a cyclic nucleotide derived from NAD, while NAADP is a linear metabolite of NADP. Systems responsive to these two novel signaling molecules are widespread among eukaryotes and include protozoan, plant, invertebrate, mammalian as well as human cells. Despite their functional and structural differences, cADPR and NAADP are sibling messengers synthesized by a single enzyme, ADP-ribosyl cyclase. In this article the recent progress in understanding the physiological roles of cADPR and NAADP is briefly reviewed. A unified mechanism of catalysis is also proposed, which takes into consideration the crystallographic structure of ADP-ribosyl cyclase and accounts for its novel multi-functionality.

About the article

Published Online: 2005-06-01

Published in Print: 1999-07-01


Citation Information: Biological Chemistry, Volume 380, Issue 7-8, Pages 785–793, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.1999.098.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Sridhar R. Vasudevan, Antony Galione, and Grant C. Churchill
Biochemical Journal, 2008, Volume 411, Number 1, Page 63
[2]
Hon Cheung Lee
Molecular Medicine, 2006, Volume 12, Number 11-12, Page 317
[4]
Alonso G. P. Guedes, Joseph A. Jude, Jaime Paulin, Laura Rivero-Nava, Hirohito Kita, Frances E. Lund, and Mathur S. Kannan
American Journal of Physiology-Lung Cellular and Molecular Physiology, 2015, Volume 308, Number 5, Page L485
[5]
Cyrus Munshi, Robert Aarhus, Richard Graeff, Timothy F. Walseth, David Levitt, and Hon Cheung Lee
Journal of Biological Chemistry, 2000, Volume 275, Number 28, Page 21566
[6]
Cyrus B. Munshi, Richard Graeff, and Hon Cheung Lee
Journal of Biological Chemistry, 2002, Volume 277, Number 51, Page 49453
[7]
[8]
Deepak A. Deshpande, Alonso G.P. Guedes, Frances E. Lund, Subbaya Subramanian, Timothy F. Walseth, and Mathur S. Kannan
Pharmacology & Therapeutics, 2017, Volume 172, Page 116
[9]
Thomas H. Gillingwater and Richard R. Ribchester
The Journal of Physiology, 2001, Volume 534, Number 3, Page 627
[10]
Gerald Schönknecht
Plants, 2013, Volume 2, Number 4, Page 589
[11]
H. C. Lee
Science Signaling, 2000, Volume 2000, Number 40, Page pe1
[12]
S. Vanderauwera, M. De Block, N. Van de Steene, B. van de Cotte, M. Metzlaff, and F. Van Breusegem
Proceedings of the National Academy of Sciences, 2007, Volume 104, Number 38, Page 15150
[13]
Katrin Schweitzer, Georg W. Mayr, and Andreas H. Guse
Analytical Biochemistry, 2001, Volume 299, Number 2, Page 218
[14]
B. Esposito, G. Gambara, A. M. Lewis, F. Palombi, A. D'Alessio, L. X. Taylor, A. A. Genazzani, E. Ziparo, A. Galione, G. C. Churchill, and A. Filippini
Blood, 2011, Volume 117, Number 18, Page 4968
[15]
Andrew Yen
Leukemia Research, 2007, Volume 31, Number 4, Page 423
[16]
Jean-Jacques Lacapère, Geneviève Boulla, Frances E Lund, Julie Primack, Norman Oppenheimer, Francis Schuber, and Philippe Deterre
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2003, Volume 1652, Number 1, Page 17
[17]
HongMin Zhang, Richard Graeff, Zhe Chen, LiangRen Zhang, LiHe Zhang, HonCheung Lee, and Quan Hao
Journal of Molecular Biology, 2011, Volume 405, Number 4, Page 1070
[18]
Johanna Congleton, Hong Jiang, Fabio Malavasi, Hening Lin, and Andrew Yen
Experimental Cell Research, 2011, Volume 317, Number 7, Page 910
[19]
Clairce L.S. Pagadigorria, Fernanda Marcon, Ana M. Kelmer-Bracht, Adelar Bracht, and Emy L. Ishii-Iwamoto
Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 2006, Volume 143, Number 3, Page 340
[20]
Danny H. Kim, Shane Que Hee, Andrew J. Norris, Kym F. Faull, and Curtis D. Eckhert
Journal of Chromatography A, 2006, Volume 1115, Number 1-2, Page 246
[21]
Liyun Zhang, Xiaolong Xu, Zhaofeng Luo, Dengke Shen, and Hao Wu
Biochimie, 2009, Volume 91, Number 2, Page 240
[22]
Ni Bai, Hon Cheung Lee, and Ismail Laher
Pharmacology & Therapeutics, 2005, Volume 105, Number 2, Page 189
[23]
Armando A Genazzani and Richard A Billington
Trends in Pharmacological Sciences, 2002, Volume 23, Number 4, Page 165
[24]
William R. Hartman, Linda L. Pelleymounter, Irene Moon, Krishna Kalari, Mohan Liu, Tse-Yu Wu, Carlos Escande, Veronica Nin, Eduardo N. Chini, and Richard M. Weinshilboum
Leukemia & Lymphoma, 2010, Volume 51, Number 7, Page 1315
[25]
Hon Cheung Lee
Annual Review of Pharmacology and Toxicology, 2001, Volume 41, Number 1, Page 317
[26]
Guido Gambara, Richard A. Billington, Marcella Debidda, Alessio D'Alessio, Fioretta Palombi, Elio Ziparo, Armando A. Genazzani, and Antonio Filippini
Journal of Cellular Physiology, 2008, Volume 216, Number 2, Page 396
[27]
Andrew Y. Zhang and Pin - Lan Li
Journal of Cellular and Molecular Medicine, 2006, Volume 10, Number 2, Page 407
[28]
Thomas J. Lamkin, Vivian Chin, Susi Varvayanis, James L. Smith, R. Michael Sramkoski, James W. Jacobberger, and Andrew Yen
Journal of Cellular Biochemistry, 2006, Volume 97, Number 6, Page 1328
[29]
S. A. Hamodeh, M. Rehn, G. Haschke, and M. Diener
Neurogastroenterology and Motility, 2004, Volume 16, Number 5, Page 597
[30]
P.-L. Li, H. C. Lee, M. T. Nelson, G. A. Meininger, and C. Van Breemen
Acta Physiologica Scandinavica, 2003, Volume 179, Number 4, Page 339

Comments (0)

Please log in or register to comment.
Log in