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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

12 Issues per year


IMPACT FACTOR 2017: 3.022

CiteScore 2017: 2.81

SCImago Journal Rank (SJR) 2017: 1.562
Source Normalized Impact per Paper (SNIP) 2017: 0.705

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ISSN
1437-4315
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Volume 380, Issue 7-8

Issues

Genetically Engineered and Synthetic Allergen Derivatives: Candidates for Vaccination against Type I Allergy

R. Valenta / S. Vrtala / M. Focke-Tejkl / A. Bugajska-Schretter / T. Ball / A. Twardosz / S. Spitzauer / H. Grönlund / D. Kraft
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/BC.1999.101

Abstract

Type I allergy, a hypersensitivity disease affecting almost 20% of the population worldwide, is based on the IgE recognition of otherwise harmless antigens (i.e., allergens). Allergen-induced crosslink of effectorcell-bound IgE antibodies leads to the release of biological mediators and thus to immediate disease symptoms (allergic rhinitis, conjunctivitis and asthma). Specific immunotherapy, the only causative treatment of Type I allergy, is based on the administration of increasing doses of allergens to allergic patients in order to yield allergen-specific non-responsiveness. Major disadvantages are 1. that current forms of allergen immunotherapy are performed with allergens difficult to standardize which cannot be matched to the patients reactivity profile and 2. that the administration of active allergen preparations can cause anaphylactic side effects. Through the application of molecular biological techniques many relevant environmental allergens have been produced as active recombinant proteins which allow component-resolved allergy diagnosis and thus represent the basis for patient-tailored forms of immunotherapy. Here we review molecular strategies which have been recently applied to generate genetically engineered and synthetic hypoallergenic allergen derivatives for patient-tailored and safe vaccination against Type I allergy.

About the article

Published Online: 2005-06-01

Published in Print: 1999-07-01


Citation Information: Biological Chemistry, Volume 380, Issue 7-8, Pages 815–824, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.1999.101.

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