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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred

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A Role of Poly (ADP-Ribose) Polymerase in NF- B Transcriptional Activation

P. O. Hassa / M. O. Hottiger
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/BC.1999.118

Abstract

The transcription factor NF-κB plays a critical role in immune and inflammatory responses. Here we show that poly (ADP ribose) polymerase (PARP) is required for specific NF-κB transcriptional activation in vivo. The activation of the HIV-LTR promoter and an NF-κBdependent artificial promoter was drastically reduced in PARP (_/_) cells, independently of the signaling pathway through which NF-bB was induced. Furthermore NF-κB-dependent gene activation was restored in vivo by the expression of PARP in PARP (_/_) cells. Finally, we show that both NF-κB and PARP formed a stable immunoprecipitable nuclear complex. This interaction did not need DNA binding. Our results suggest that PARP is an important cofactor in the activation cascade of NF-κB-dependent target genes.


Published Online: 2005-06-01

Published in Print: 1999-07-01


Citation Information: Biological Chemistry. Volume 380, Issue 7-8, Pages 953–959, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.1999.118, June 2005

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