Jump to ContentJump to Main Navigation
Show Summary Details

Buchner, Johannes

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred

SCImago Journal Rank (SJR) 2015: 1.607
Source Normalized Impact per Paper (SNIP) 2015: 0.751
Impact per Publication (IPP) 2015: 2.609

See all formats and pricing



Select Volume and Issue


30,00 € / $42.00 / £23.00

Get Access to Full Text

The Role of Protein Phosphatase 2A Catalytic Subunit Cα in Embryogenesis: Evidence from Sequence Analysis and Localization Studies

Jürgen Götz / Wilfried Kues

Citation Information: Biological Chemistry. Volume 380, Issue 9, Pages 1117–1120, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.1999.139, June 2005

Publication History

Published Online:


Protein phosphatase 2A (PP2A) constitutes one of the major families of protein serine/threonine phosphatases found in all eukaryotic cells. PP2A holoenzymes are composed of a catalytic subunit complexed with a structural regulatory subunit of 65 kDa. These core subunits associate with regulatory subunits of various sizes to form different heterotrimers which have been purified and evaluated with regard to substrate specificity. In fully differentiated tissues PP2A expression levels are highest in the brain, however, relatively little is known about expression in the developing embryo.

In order to determine the composition of PP2A catalytic subunits in the mouse, cDNAs were cloned and the genomic organization of PP2A Cα was determined.

By a gene targeting approach in the mouse, we have previously shown that the absence of the major catalytic subunit of PP2A, Cα, resulted in embryonic lethality around embryonic day E6.5. No mesoderm was formed which implied that PP2A plays a crucial role in gastrulation.

Here, we extended our studies and analyzed wildtype embryos for Cα expression at subsequent stages of development. After gastrulation is completed, we find high expression of Cα restricted to the neural folds, which suggests that PP2A plays an additional pivotal role in neurulation.

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Jürgen Götz, Amadeus Gladbach, Luis Pennanen, Janet van Eersel, Andreas Schild, Della David, and Lars M. Ittner
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2010, Volume 1802, Number 10, Page 860
Marco Gymnopoulos, Lorenzo A. Cingolani, Paola Pedarzani, and Martin Stocker
Journal of Comparative Neurology, 2014, Volume 522, Number 5, Page 1072
Chuanhuan Deng, Xinbing Yu, Xuerong Li, Jiufeng Sun, Lexun Wang, Xiaoyun Wang, Wenjun Chen, Xiaoli Lv, Xuchu Hu, Zhongdao Wu, Chi Liang, and Jin Xu
Parasitology Research, 2012, Volume 110, Number 5, Page 1951
J. Solano-Parada, G. Gonzalez-Gonzalez, L.M. de Pablos Torró, M.F. Brazil dos Santos, A.M. Espino, M. Burgos, and A. Osuna
Vaccine, 2010, Volume 28, Number 32, Page 5185
Wayde M Weston, Angela B Freeman, Christian Haberecht, Rita C Hackmiller, Linh Ma, Paul Nugent, Edward Warr, M.Michele Pisano, and Robert M Greene
Life Sciences, 2002, Volume 71, Number 16, Page 1849
Jürgen Götz, Alphonse Probst, Claudia Mistl, Roger M Nitsch, and Elisabeth Ehler
Mechanisms of Development, 2000, Volume 93, Number 1-2, Page 83
Annals of the New York Academy of Sciences, 2006, Volume 920, Number 1, Page 126
Karsten Schmidt, Stefan Kins, Andreas Schild, Roger M. Nitsch, Brian A. Hemmings, and Jurgen Gotz
European Journal of Neuroscience, 2002, Volume 16, Number 11, Page 2039

Comments (0)

Please log in or register to comment.