Jump to ContentJump to Main Navigation
Show Summary Details

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred

12 Issues per year

IMPACT FACTOR 2015: 2.710
Rank 142 out of 289 in category Biochemistry & Molecular Biology in the 2015 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2015: 1.607
Source Normalized Impact per Paper (SNIP) 2015: 0.751
Impact per Publication (IPP) 2015: 2.609

See all formats and pricing



Select Volume and Issue


30,00 € / $42.00 / £23.00

Get Access to Full Text

Adjuvant and Haemolytic Activities of 47 Saponins Derived from Medicinal and Food Plants

Kenji Oda / Hisashi Matsuda / Toshiyuki Murakami / Shigeji Katayama / Toshiaki Ohgitani / Masayuki Yoshikawa
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/BC.2000.009


Adjuvant and haemolytic activities of 47 saponins purified from medicinal and food plants were examined. The compounds showed various levels of both adjuvant and haemolytic activities. Soyasaponins and lablabosides showed strong adjuvant activity but little haemolytic activity. Jujubosides showed strong adjuvant and haemolytic activities. Escins showed weaker adjuvant activity than the adjuvant-control, but strong haemolytic activity. Comparison of the functional groups of each saponin revealed that the acyl residue in saponin, the aldehyde group at carbon 4 in aglycone, and branched sugar chains attached to aglycone, were not essential for adjuvant activity. Furthermore, saponins with an acyl residue or oxide-ring moiety tended to show haemolytic activity. These results suggest that the adjuvant activity of saponins does not relate with haemolytic activity. It is considered that not only the functional groups themselves, but the overall conformation harmoniously consisting of such functional groups, affects adjuvant activity of saponins.

Published Online: 2005-06-01

Published in Print: 2000-01-28

Citation Information: Biological Chemistry. Volume 381, Issue 1, Pages 67–74, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2000.009, June 2005

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

William E. Walkowicz, Alberto Fernández-Tejada, Constantine George, Francisco Corzana, Jesús Jiménez-Barbero, Govind Ragupathi, Derek S. Tan, and David Y. Gin
Chem. Sci., 2016, Volume 7, Number 3, Page 2371
C. A. Ram�rez-Restrepo, C. J. O'Neill, N. L�pez-Villalobos, J. Padmanabha, J. K. Wang, and C. McSweeney
Animal Production Science, 2016, Volume 56, Number 3, Page 457
Kinga Kuczynska, Piotr Cmoch, Lucie Rárová, Jana Oklešťková, Anna Korda, Zbigniew Pakulski, and Miroslav Strnad
Carbohydrate Research, 2016
Vicki A. Motz, Christopher P. Bowers, Alexander R. Kneubehl, Elizabeth C. Lendrum, Linda M. Young, and David H. Kinder
Journal of Ethnopharmacology, 2015, Volume 162, Page 163
Ya-min Liu, Zong-yang Li, Han Hu, Shu-ping Xu, Qi Chang, Yong-hong Liao, Rui-le Pan, and Xin-min Liu
Pharmacology Biochemistry and Behavior, 2015, Volume 128, Page 14
Tao Sun, Xinbin Yan, Wenxiu Guo, and Dayun Zhao
Phytomedicine, 2014, Volume 21, Number 13, Page 1759
Tessa Moses, Kalliope K. Papadopoulou, and Anne Osbourn
Critical Reviews in Biochemistry and Molecular Biology, 2014, Volume 49, Number 6, Page 439
Shaik Abdul Hussain, Narender Raju Panjagari, R. R. B. Singh, and G. R. Patil
Critical Reviews in Food Science and Nutrition, 2015, Volume 55, Number 1, Page 94
Jubeda Begum, Pranabananda Das, Madhu Cholenahalli Lingaraju, Sudhakar Ranjanna, Karuna Irungbam, Anand Mohan, and Radhika Syam
Veterinary World, 2014, Volume 7, Number 7, Page 528
Piotr Cmoch, Anna Korda, Lucie Rárová, Jana Oklešt'ková, Miroslav Strnad, Katarzyna Gwardiak, Romuald Karczewski, and Zbigniew Pakulski
European Journal of Organic Chemistry, 2014, Volume 2014, Number 19, Page 4089
Jyoti Bhardwaj, Narendra Chaudhary, Hyo-Jin Seo, Min-Yong Kim, Tai-Sun Shin, and Jong-Deog Kim
Immunopharmacology and Immunotoxicology, 2014, Volume 36, Number 3, Page 202
B. M. Olabinri, E. A. Adepoju, A. A. Zainab, and A. A. Ahmed
Journal of Pharmacognosy and Phytotherapy, 2014, Volume 6, Number 2, Page 17
Piotr Cmoch, Anna Korda, Lucie Rárová, Jana Oklešťková, Miroslav Strnad, Roman Luboradzki, and Zbigniew Pakulski
Tetrahedron, 2014, Volume 70, Number 17, Page 2717
Bernadete Pereira da Silva and José Paz Parente
Phytochemistry Letters, 2013, Volume 6, Number 4, Page 633
V Thanga Viji, K Deepa, S Velmurugan, MBS Donio, J Adlin Jenifer, MM Babu, and T Citarasu
Diseases of Aquatic Organisms, 2013, Volume 104, Number 1, Page 45
Li-Ru Lai, Shu-Chen Hsieh, Hui-Yu Huang, and Cheng-Chun Chou
Journal of Bioscience and Bioengineering, 2013, Volume 115, Number 5, Page 552
Ramasamy Harikrishnan, Hong-Joo Son, Dong-Hwi Kim, Seung-Hyun Hong, Pitchaimuthu Mariappan, Chellam Balasundaram, and Moon-Soo Heo
Fish & Shellfish Immunology, 2012
Antony de Paula Barbosa, Bernadete Pereira da Silva, and José Paz Parente
Phytochemistry Letters, 2012, Volume 5, Number 3, Page 626
Jigang Zhang, Wenjie Cao, Junmian Tian, Rongcai Yue, Li Li, Baoyu Guo, Lei Shan, Biao Yu, and Weidong Zhang
International Immunopharmacology, 2012, Volume 14, Number 1, Page 21
Jemal Demma, Hesham El-Seedi, Ephrem Engidawork, Teshome Leta Aboye, Ulf Göransson, and Björn Hellman
Phytotherapy Research, 2013, Volume 27, Number 4, Page 507
Charles Gauthier, Jean Legault, Serge Lavoie, Simon Rondeau, Samuel Tremblay, and André Pichette
Tetrahedron, 2008, Volume 64, Number 30-31, Page 7386
Bernardino Roca
The American Journal of Medicine, 2003, Volume 115, Number 8, Page 677
Satchithanandam Eswaranandam, Joseph Salyer, Pengyin Chen, and Sun-Ok Lee
Journal of Food Science, 2012, Volume 77, Number 2, Page H81
Camila Rodrigues Adão, Bernadete Pereira da Silva, Luzineide Wanderley Tinoco, and José Paz Parente
Chemistry & Biodiversity, 2012, Volume 9, Number 1, Page 58
Tábitha Dahmer Rocha, Patrícia de Brum Vieira, Simone Cristina Baggio Gnoatto, Tiana Tasca, and Grace Gosmann
Parasitology Research, 2012, Volume 110, Number 6, Page 2551
Hongxiang Sun, Liqing Chen, Juanjuan Wang, Kuiwu Wang, and Jiyong Zhou
International Immunopharmacology, 2011, Volume 11, Number 12, Page 2047
Jian-hua Sun, Zhong-qi Jiang, and Song-hua Hu
Veterinary Immunology and Immunopathology, 2008, Volume 121, Number 1-2, Page 107
Nádia das Dores Moreira, Rodolfo Cordeiro Giunchetti, Cláudia Martins Carneiro, Juliana Vitoriano-Souza, Bruno Mendes Roatt, Luiz Cosme Cotta Malaquias, Rodrigo Corrêa-Oliveira, and Alexandre Barbosa Reis
Veterinary Immunology and Immunopathology, 2009, Volume 128, Number 4, Page 418
Charles Gauthier, Jean Legault, Marianne Piochon-Gauthier, and André Pichette
Phytochemistry Reviews, 2011, Volume 10, Number 4, Page 521
Jun-Xia Xiao, Guo-Qing Huang, Cai-Ping Zhu, Dan-Dan Ren, and Sheng-Hua Zhang
Toxicology in Vitro, 2007, Volume 21, Number 5, Page 820
Y.-M. Cho, T. Imai, Y. Ito, S. Takami, M. Hasumura, T. Yamazaki, M. Hirose, and A. Nishikawa
Food and Chemical Toxicology, 2009, Volume 47, Number 8, Page 2150
Yongxu Sun, Jicheng Liu, Haitao Yu, and Chunjie Gong
International Immunopharmacology, 2010, Volume 10, Number 5, Page 584
Camila Rodrigues Adão, Bernadete Pereira da Silva, and José Paz Parente
Fitoterapia, 2011, Volume 82, Number 8, Page 1175
Yongxu Sun, Haibin Tong, Mingquan Li, Yujuan Li, Shuwen Guan, and Jicheng Liu
Vaccine, 2008, Volume 26, Number 47, Page 5911
Hong-Xiang Sun, Yong Xie, and Yi-Ping Ye
Vaccine, 2009, Volume 27, Number 12, Page 1787
S.G. Sparg, M.E. Light, and J. van Staden
Journal of Ethnopharmacology, 2004, Volume 94, Number 2-3, Page 219
L.E. Parra, G.P. Borja-Cabrera, F.N. Santos, L.O.P. Souza, C.B. Palatnik-de-Sousa, and I. Menz
Vaccine, 2007, Volume 25, Number 12, Page 2180
Christopher B. Fox, Susan Lin, Sandra J. Sivananthan, Timothy S. Dutill, Kristen T. Forseth, Steven G. Reed, and Thomas S. Vedvick
Pharmaceutical Development and Technology, 2011, Volume 16, Number 5, Page 511
Tatiana Paz Mendes, Graziela De Medeiros Silva, Bernadete Pereira Da Silva, and José Paz Parente
Natural Product Research, 2004, Volume 18, Number 2, Page 183
Erik L. Regalado, Tom Turk, Deniz Tasdemir, Manca Gorjanc, Marcel Kaiser, Olivier P. Thomas, Rogelio Fernández, and Philippe Amade
Steroids, 2011, Volume 76, Number 12, Page 1389
B. Ncube, V.N.P. Ngunge, J.F. Finnie, and J. Van Staden
Journal of Ethnopharmacology, 2011, Volume 134, Number 3, Page 775
S.M. Nasr, S. Abdel-Shafy, H.H. Abdel-Rahman, and S.M. Habeeb
Toxicological & Environmental Chemistry, 2011, Volume 93, Number 8, Page 1693
Alison M. Daines, Ben W. Greatrex, Colin M. Hayman, Sarah M. Hook, Warren T. McBurney, Thomas Rades, Phillip M. Rendle, and Ian M. Sims
Bioorganic & Medicinal Chemistry, 2009, Volume 17, Number 14, Page 5207
Martin Chwalek, Nathalie Lalun, Hélène Bobichon, Karen Plé, and Laurence Voutquenne-Nazabadioko
Biochimica et Biophysica Acta (BBA) - General Subjects, 2006, Volume 1760, Number 9, Page 1418
Jean-Paul Vincken, Lynn Heng, Aede de Groot, and Harry Gruppen
Phytochemistry, 2007, Volume 68, Number 3, Page 275
Karel Decroos, Jean-Paul Vincken, Gerrit A. van Koningsveld, Harry Gruppen, and Willy Verstraete
Food Chemistry, 2007, Volume 101, Number 1, Page 324
Bernadete Pereira Da Silva, Ana Paula Valente, and José Paz Parente
Natural Product Research, 2006, Volume 20, Number 4, Page 385
Özlem Güçlü-Üstündağ and Giuseppe Mazza
Critical Reviews in Food Science and Nutrition, 2007, Volume 47, Number 3, Page 231
Jörg M. Augustin, Vera Kuzina, Sven B. Andersen, and Søren Bak
Phytochemistry, 2011, Volume 72, Number 6, Page 435
Georgios S. Katselis, Alberto Estrada, Dennis K.J. Gorecki, and Branka Barl
Canadian Journal of Physiology and Pharmacology, 2007, Volume 85, Number 11, Page 1184
John Shi, Konesh Arunasalam, David Yeung, Yukio Kakuda, Gauri Mittal, and Yueming Jiang
Journal of Medicinal Food, 2004, Volume 7, Number 1, Page 67
Carlos Gamazo and Juan Manuel Irache
Expert Review of Vaccines, 2009, Volume 8, Number 10, Page 1333
Åshild Krogdahl, Michael Penn, Jim Thorsen, Ståle Refstie, and Anne Marie Bakke
Aquaculture Research, 2010, Volume 41, Number 3, Page 333
George Francis, Zohar Kerem, Harinder P. S. Makkar, and Klaus Becker
British Journal of Nutrition, 2002, Volume 88, Number 06, Page 587
Tiwatt Kuljanabhagavad and Michael Wink
Phytochemistry Reviews, 2009, Volume 8, Number 2, Page 473
Masayuki YOSHIKAWA, Toshio MORIKAWA, Kenichi YASHIRO, Toshiyuki MURAKAMI, and Hisashi MATSUDA
CHEMICAL & PHARMACEUTICAL BULLETIN, 2001, Volume 49, Number 11, Page 1452
Zahid Iqbal Rajput, Chen-wen Xiao, Song-hua Hu, Abdullah G. Arijo, and Noor Mohammad Soomro
Journal of Zhejiang University SCIENCE B, 2007, Volume 8, Number 5, Page 331
Feng Qin, Yi-Ping Ye, and Hong-Xiang Sun
Chemistry & Biodiversity, 2006, Volume 3, Number 10, Page 1144
Bernadete Pereira da Silva, Patricia Oliveira Campos, and Jose Paz Parente
Chemistry of Natural Compounds, 2006, Volume 42, Number 3, Page 316
Hong-Xiang Sun, Yuehua Chen, and Yiping Ye
Chemistry & Biodiversity, 2006, Volume 3, Number 7, Page 718
Anna Szakiel, Dariusz Ruszkowski, and Wirginia Janiszowska
Phytochemistry Reviews, 2005, Volume 4, Number 2-3, Page 151
Hongxiang Sun and Quanfang Zheng
Phytotherapy Research, 2005, Volume 19, Number 10, Page 895
Alexandra da Silva Antunes, Bernadete Pereira da Silva, Jos� Paz Parente, and Ana Paula Valente
Phytotherapy Research, 2003, Volume 17, Number 2, Page 179

Comments (0)

Please log in or register to comment.