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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

12 Issues per year

IMPACT FACTOR 2016: 3.273

CiteScore 2016: 3.01

SCImago Journal Rank (SJR) 2016: 1.679
Source Normalized Impact per Paper (SNIP) 2016: 0.800

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Volume 381, Issue 11 (Nov 2000)


Cytokine-Inducing Activity of Family 2 Cystatins

T. Kato / T. Imatani / T. Miura / K. Minaguchi / E. Saitoh / K. Okuda
Published Online: 2005-07-05 | DOI: https://doi.org/10.1515/BC.2000.141


Cystatins are physiological cysteine proteinase inhibitors. Here we report a novel function for some family 2 cystatins that is not related to these activities. The release of interleukin-6 (IL-6) and interleukin-8 (IL-8) by the gingival fibroblasts and that of IL-6 by murine splenocytes were measured using ELISA systems specific for these cytokine molecules. Family 2 cystatins, including cystatins C, SA1, SA2, S, and egg white cystatin, upregulated the IL-6 production by two human gingival fibroblast cell lines or murine splenocytes and also the IL-8 production by gingival fibroblasts at physiological concentrations. After complete saturation with papain, those family 2 cystatins still upregulated IL-6 production, suggesting that the papain- inhibitory site was not involved in the cytokine-inducing activity.

About the article

Published Online: 2005-07-05

Published in Print: 2000-11-15

Citation Information: Biological Chemistry, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2000.141.

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