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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

12 Issues per year


IMPACT FACTOR 2016: 3.273

CiteScore 2017: 2.81

SCImago Journal Rank (SJR) 2017: 1.562
Source Normalized Impact per Paper (SNIP) 2017: 0.705

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1437-4315
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Volume 381, Issue 5-6

Issues

Signal Transduction and Post-Transcriptional Gene Expression

K.F. Wilson / R.A. Cerione
Published Online: 2005-07-05 | DOI: https://doi.org/10.1515/BC.2000.048

Abstract

Traditionally, growth factor-coupled signaling to the nucleus has been thought to be primarily directed toward transcriptional regulation. However, there are now increasing indications from a diversity of experimental systems that other aspects of RNA processing, including translation, lifetime and stability, and splicing are under strict growth factor control. In this review, we present the emerging evidence for growth factor signaling pathways that impact on these different RNA processing events. Particularly noteworthy is the realization that growth factor signaling through Ras can effect the regulation of two RNA cap-binding proteins, the cytosolic eIF-4E complex, which is necessary for initiating translation, and the nuclear capbinding complex, the CBC, which plays a role in capdependent pre-mRNA splicing, U snRNA export and 3′-end processing. This, taken together with other findings that demonstrate the ability of stress response pathways and the small G protein, Cdc42, to activate the CBC, raises some interesting possibilities regarding how signaling to the two cellular RNA cap-binding protein complexes may coordinate the growth-coupled regulation of gene expression at the level of RNA processing.

About the article

Published Online: 2005-07-05

Published in Print: 2000-06-21


Citation Information: Biological Chemistry, Volume 381, Issue 5-6, Pages 357–365, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2000.048.

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