Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

IMPACT FACTOR 2018: 3.014
5-year IMPACT FACTOR: 3.162

CiteScore 2018: 3.09

SCImago Journal Rank (SJR) 2018: 1.482
Source Normalized Impact per Paper (SNIP) 2018: 0.820

See all formats and pricing
More options …
Volume 381, Issue 5-6


Signal Transduction and Post-Transcriptional Gene Expression

K.F. Wilson / R.A. Cerione
Published Online: 2005-07-05 | DOI: https://doi.org/10.1515/BC.2000.048


Traditionally, growth factor-coupled signaling to the nucleus has been thought to be primarily directed toward transcriptional regulation. However, there are now increasing indications from a diversity of experimental systems that other aspects of RNA processing, including translation, lifetime and stability, and splicing are under strict growth factor control. In this review, we present the emerging evidence for growth factor signaling pathways that impact on these different RNA processing events. Particularly noteworthy is the realization that growth factor signaling through Ras can effect the regulation of two RNA cap-binding proteins, the cytosolic eIF-4E complex, which is necessary for initiating translation, and the nuclear capbinding complex, the CBC, which plays a role in capdependent pre-mRNA splicing, U snRNA export and 3′-end processing. This, taken together with other findings that demonstrate the ability of stress response pathways and the small G protein, Cdc42, to activate the CBC, raises some interesting possibilities regarding how signaling to the two cellular RNA cap-binding protein complexes may coordinate the growth-coupled regulation of gene expression at the level of RNA processing.

About the article

Published Online: 2005-07-05

Published in Print: 2000-06-21

Citation Information: Biological Chemistry, Volume 381, Issue 5-6, Pages 357–365, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2000.048.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Nature Biotechnology, 2000, Volume 18, Number S10, Page IT37
Alexandre Rodrigues Caetano, Rodger K. Johnson, J. Joe Ford, and Daniel Pomp
Genetics, 2004, Volume 168, Number 3, Page 1529
Istv�n Papp, Luis mur, �gnes Dalmadi, S�ndor Dulai, and Csaba Koncz
Plant Molecular Biology, 2004, Volume 55, Number 5, Page 679
Graham R. Scott, Jeff G. Richards, Biff Forbush, Paul Isenring, and Patricia M. Schulte
American Journal of Physiology-Cell Physiology, 2004, Volume 287, Number 2, Page C300
V. Lehmensiek, SD Süssmuth, G. Tauscher, J. Brettschneider, S. Felk, F. Gillardon, and H. Tumani
Multiple Sclerosis Journal, 2007, Volume 13, Number 7, Page 840
Becky L. Drees, Bryan Sundin, Elizabeth Brazeau, Juliane P. Caviston, Guang-Chao Chen, Wei Guo, Keith G. Kozminski, Michelle W. Lau, John J. Moskow, Amy Tong, Laura R. Schenkman, Amos McKenzie, Patrick Brennwald, Mark Longtine, Erfei Bi, Clarence Chan, Peter Novick, Charles Boone, John R. Pringle, Trisha N. Davis, Stanley Fields, and David G. Drubin
The Journal of Cell Biology, 2001, Volume 154, Number 3, Page 549
Liming Xiong, Zhizhong Gong, Christopher D. Rock, Senthil Subramanian, Yan Guo, Wenying Xu, David Galbraith, and Jian-Kang Zhu
Developmental Cell, 2001, Volume 1, Number 6, Page 771
C. F. W. Becker, C. L. Hunter, R. Seidel, S. B. H. Kent, R. S. Goody, and M. Engelhard
Proceedings of the National Academy of Sciences, 2003, Volume 100, Number 9, Page 5075
Sheri A. Denslow, Amanda A. Walls, and Margaret E. Daub
Physiological and Molecular Plant Pathology, 2005, Volume 66, Number 6, Page 244
Lynne E. Maquat, Woan-Yuh Tarn, and Olaf Isken
Cell, 2010, Volume 142, Number 3, Page 368
Min Seok Bae, Eun Ju Cho, Eun-Young Choi, and Ohkmae K. Park
The Plant Journal, 2003, Volume 36, Number 5, Page 652
Chad M. Kitchen, Sara W. Leung, Anita H. Corbett, and T. J. Murphy
Yeast, 1990, Volume 26, Number 5, Page 261
Manish R. Patel, Blake A. Jacobson, Arpita De, Sandra P. Frizelle, Pasi Janne, Saritha C. Thumma, Brian A. Whitson, Faris Farassati, and Robert A. Kratzke
Journal of Thoracic Oncology, 2007, Volume 2, Number 9, Page 789
Woan-Yuh Tarn
Journal of Biomedical Science, 2007, Volume 14, Number 4, Page 517

Comments (0)

Please log in or register to comment.
Log in