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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

IMPACT FACTOR 2018: 3.014
5-year IMPACT FACTOR: 3.162

CiteScore 2018: 3.09

SCImago Journal Rank (SJR) 2018: 1.482
Source Normalized Impact per Paper (SNIP) 2018: 0.820

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Volume 382, Issue 10


Protein-DNA Interaction and CpG Methylation at rep*/vIL-10p of Latent Epstein-Barr Virus Genomes in Lymphoid Cell Lines

H.H. Niller / D. Salamon / M. Takacs / J. Uhlig / H. Wolf / J. Minarovits
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/BC.2001.174


The viral interleukin-10 promoter (vIL-10p), overlapping the rep* element in the EpsteinBarr virus (EBV) genome, is a promoter element active mostly in the late phase of the lytic cycle and immediately upon infection of B cells. rep* was, through transfection experiments with small plasmids, characterised as a cis element supporting oriP replicative function. In this study, in vivo protein binding and CpG methylation at rep*/vIL-10p were analysed in five cell lines that harbour strictly latent EBV genomes. Contrary to the invariably unmethylated dyad symmetry element (DS) of oriP, rep*/vIL-10p was highly methylated and showed only traces of protein binding in all examined cell lines. This result is in agreement with vIL-10p being an inactive promoter of EBV genomes, and makes it less likely that rep* functions as a replicative element of latent EBV genomes.

About the article

Published Online: 2005-06-01

Published in Print: 2001-10-15

Citation Information: Biological Chemistry, Volume 382, Issue 10, Pages 1411–1419, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2001.174.

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