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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred

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Identification of Receptors for Prothymosin α on Human Lymphocytes

A. Piñeiro / M. Begoña Bugía / M. Pilar Arias / O.J. Cordero / M. Nogueira
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/BC.2001.181

Abstract

Prothymosin α (ProTα ) is a highly conserved and widely distributed protein whose physiological functions remain elusive. In previous work we identified high and low affinitybinding sites for ProTα in lymphoid cells. Here we demonstrate, by affinity crosslinking and affinity chromatography, the existence of three binding partners (31, 29, and 19kDa) for ProTα in the membrane of PHAactivated lymphoblasts. These surface molecules possess the expected affinity and specificity for a ProTα receptor. Examination of the expression of this complex of molecules by flow cytometry reveals that they bind ProTα in a specific and saturable way. In addition, the distribution of the receptor on the cell surface was studied by fluorescence microscopy; a caplike structure at one of the poles of the cells was identified. These results represent a new and promising approach in the research on ProTα, opening the way toward the understanding of the molecular mechanism of action of this protein.


Published Online: 2005-06-01

Published in Print: 2001-10-15


Citation Information: Biological Chemistry. Volume 382, Issue 10, Pages 1473–1482, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2001.181, June 2005

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