Jump to ContentJump to Main Navigation
Show Summary Details
Weitere Optionen …

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Wissenschaftlicher Beirat: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred


IMPACT FACTOR 2018: 3.014
5-year IMPACT FACTOR: 3.162

CiteScore 2018: 3.09

SCImago Journal Rank (SJR) 2018: 1.482
Source Normalized Impact per Paper (SNIP) 2018: 0.820

Online
ISSN
1437-4315
Alle Formate und Preise
Weitere Optionen …
Band 382, Heft 2

Hefte

The Liver Flukes Fasciola gigantica and Fasciola hepatica Express the Leucocyte Cluster of Differentiation Marker CD77 (Globotriaosylceramide) in Their Tegument

Manfred Wuhrer / Clemens Berkefeld / Roger D. Dennis / Mohamed A. Idris / Rudolf Geyer
Online erschienen: 01.06.2005 | DOI: https://doi.org/10.1515/BC.2001.027

Abstract

Glycosphingolipids from the parasitic liver flukes F a sciola gigantica and Fasciola hepatica w e re isolated and their carbohydrate moieties were structurally analysed by methylation analysis, exoglycosidase t reatment, ontarget exoglycosidase cleavage and matrixassisted laser desorption/ionisation timeofflight mass spectrometry. For both liver fluke species, the ceramide monohexosides Gal1-ceramide and Glc1-ceramide were found in relative amounts of 1.0 to 0.1, respectively. From F. gigantica, the ceramide dihexoside was isolated in sufficient amounts to be structurally determined as lactosylceramide, Gal?4- Glc1-ceramide, while for both liver fluke species the ceramide trihexoside was shown to be Gal?4 G a lb4- Glc1-ceramide, which is designated as either globotriaosylceramide, Pblood group antigen or CD77 leucocyte cluster of diff e rentiation antigen. To our knowledge, this is the first report on the expression of globoseries glycosphingolipids in nonmammalian species. Ceramide analysis of ceramide monohexosides yielded as major components octadecanoic and 2 h y d roxyoctadecanoic fatty acids together with C18- and C20-phytosphingosines. By the use of an anti CD77 monoclonal antibody and the Escherichia coli Shiga toxin B1 subunit, globotriaosylceramide could be immunolocalised to the tegument of F. hepatica cryosections. The sharing of CD77 between liver flukes and their mammalian hosts fits in with the concept of molecular mimicry, which is closely parallel to the established imitation of host CD15 (Lewis X) displayed by the blood fluke Schistosoma mansoni.

Artikelinformationen

Online erschienen: 01.06.2005

Erschienen im Druck: 12.02.2001


Quellenangabe: Biological Chemistry, Band 382, Heft 2, Seiten 195–207, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2001.027.

Zitat exportieren

Zitierende Artikel

Hier finden Sie eine Übersicht über alle Crossref-gelisteten Publikationen, in denen dieser Artikel zitiert wird. Um automatisch über neue Zitierungen dieses Artikels informiert zu werden, aktivieren Sie einfach oben auf dieser Seite den „E-Mail-Alert: Neu zitiert“.

[1]
Fu-Kai Zhang, Rui-Si Hu, Hany M. Elsheikha, Zhao-An Sheng, Wei-Yu Zhang, Wen-Bin Zheng, Xing-Quan Zhu, and Jun-Jun He
Parasites & Vectors, 2019, Jahrgang 12, Nummer 1
[2]
Maureen Feucherolles, Sven Poppert, Jürg Utzinger, and Sören L. Becker
Parasites & Vectors, 2019, Jahrgang 12, Nummer 1
[3]
Krystyna Cwiklinski and John P. Dalton
International Journal for Parasitology, 2018
[4]
Alessandra Ravidà, Allison M. Aldridge, Nicole N. Driessen, Ferry A. H. Heus, Cornelis H. Hokke, Sandra M. O’Neill, and John Pius Dalton
PLOS Neglected Tropical Diseases, 2016, Jahrgang 10, Nummer 4, Seite e0004601
[5]
Andres Garcia-Campos, Alessandra Ravidà, D. Linh Nguyen, Krystyna Cwiklinski, John P. Dalton, Cornelis H. Hokke, Sandra O’Neill, Grace Mulcahy, and Aaron R. Jex
PLOS Neglected Tropical Diseases, 2016, Jahrgang 10, Nummer 5, Seite e0004688
[6]
Eman H. Abdel-Rahman, Azza H. Mohamed, Adel A. H. Abdel-Rahman, and Eman E. El Shanawany
Journal of Parasitic Diseases, 2016, Jahrgang 40, Nummer 1, Seite 11
[7]
Sandra Frank, Hildegard Geyer, and Rudolf Geyer
Journal of Carbohydrate Chemistry, 2011, Jahrgang 30, Nummer 4-6, Seite 233
[9]
N. V. Iakovleva and A. M. Gorbushin
Journal of Evolutionary Biochemistry and Physiology, 2005, Jahrgang 41, Nummer 2, Seite 143

Kommentare (0)