Jump to ContentJump to Main Navigation
Show Summary Details
In This Section

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

12 Issues per year


IMPACT FACTOR 2016: 3.273

CiteScore 2016: 3.01

SCImago Journal Rank (SJR) 2015: 1.607
Source Normalized Impact per Paper (SNIP) 2015: 0.751

Online
ISSN
1437-4315
See all formats and pricing
In This Section
Volume 382, Issue 4 (Apr 2001)

Issues

Dendritic Cells for Specific Cancer Immunotherapy

Norbert Meidenbauer / Reinhard Andreesen / Andreas Mackensen
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/BC.2001.065

Abstract

The characterization of tumorassociated antigens recognized by human T lymphocytes in a major histocompatibility complex (MHC)restricted fashion has opened new possibilities for immunotherapeutic approaches to the treatment of human cancers. Dendritic cells (DC) are professional antigen presenting cells that are well suited to activate T cells toward various antigens, such as tumorassociated antigens, due to their potent costimulatory activity. The availability of large numbers of DC, generated either from hematopoietic progenitor cells or monocytes in vitro or isolated from peripheral blood, has profoundly changed preclinical research as well as the clinical evaluation of these cells. Accordingly, appropriately pulsed or transfected DC may be used for vaccination in the field of infectious diseases or tumor immunotherapy to induce antigenspecific T cell responses. These observations led to pilot clinical trials of DC vaccination for patients with cancer in order to investigate the feasibility, safety, as well as the immunologic and clinical effects of this approach. Initial clinical studies of human DC vaccines are generating encouraging preliminary results demonstrating induction of tumorspecific immune responses and tumor regression. Nevertheless, much work is still needed to address several variables that are critical for optimizing this approach and to determine the role of DCbased vaccines in tumor immunotherapy.

About the article

Published Online: 2005-06-01

Published in Print: 2001-04-27



Citation Information: Biological Chemistry, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2001.065. Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
A.-C. Knol and B. Dréno
EMC - Dermatologie, 2007, Volume 2, Number 2, Page 1
[2]
A.-C. Knol and B. Dréno
EMC - Dermatología, 2007, Volume 41, Number 4, Page 1
[3]
S. de Chickera, C. Willert, C. Mallet, R. Foley, P. Foster, and G. A. Dekaban
International Immunology, 2012, Volume 24, Number 1, Page 29
[4]
Jia-Ming Chang, Le-Mei Hung, Yau-Jan Chyan, Chun-Ming Cheng, and Rey-Yuh Wu
Evidence-Based Complementary and Alternative Medicine, 2011, Volume 2011, Page 1
[5]
Hua Zhong, Michael R Shurin, and Baohui Han
Expert Review of Vaccines, 2007, Volume 6, Number 3, Page 333
[6]
Paweł Krawczyk, Kamila Wojas, Janusz Milanowski, and Jacek Roliński
Archivum Immunologiae et Therapiae Experimentalis, 2007, Volume 55, Number 6, Page 405
[7]
John S Lam, Arie S Belldegrun, and Robert A Figlin
Expert Opinion on Pharmacotherapy, 2006, Volume 7, Number 6, Page 705
[8]
Michael L Salgaller
Expert Opinion on Biological Therapy, 2002, Volume 2, Number 3, Page 265
[9]
M J Grimshaw, K Papazisis, G Picco, H Bohnenkamp, T Noll, J Taylor-Papadimitriou, and J Burchell
British Journal of Cancer, 2008, Volume 98, Number 4, Page 784
[10]
Christian Blank, Thomas F. Gajewski, and Andreas Mackensen
Cancer Immunology, Immunotherapy, 2005, Volume 54, Number 4, Page 307
[11]
J. Marcus Muche and Wolfram Sterry
HG Zeitschrift fur Hautkrankheiten, 2002, Volume 77, Number 12, Page 679
[12]
J. M. Muche and W. Sterry
Clinical and Experimental Dermatology, 2002, Volume 27, Number 7, Page 602

Comments (0)

Please log in or register to comment.
Log in