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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

IMPACT FACTOR 2018: 3.014
5-year IMPACT FACTOR: 3.162

CiteScore 2018: 3.09

SCImago Journal Rank (SJR) 2018: 1.482
Source Normalized Impact per Paper (SNIP) 2018: 0.820

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Volume 382, Issue 7


Singlet Molecular Oxygen Triggers the soxRS Regulon of Escherichia coli

Lucymara F. Agnez-Lima / Paolo Di Mascio / Bruce Demple / Carlos F.M. Menck
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/BC.2001.134


The electronically excited molecular oxygen (singlet oxygen, [1]O[2]) can be detrimental to cells in several ways, although recent reports indicate that it may play a role as an intercellular signal in eukaryotes. Here we present evidence that [1]O[2], generated by thermodissociation of disodium 3,3(1,4-naphthylidene) diproprionate endoperoxide, activates transcription of genes of the soxRS regulon, and that this induction is paralleled by induction of a soxS::lacZ operon fusion. The inductions were dependent on a functional soxR gene. These data imply that protective responses, such as induction of the soxRS regulon, may be triggered by diverse environmental oxidative stresses, and that [1]O[2] may also function as a signal molecule in prokaryotes.

About the article

Published Online: 2005-06-01

Published in Print: 2001-07-20

Citation Information: Biological Chemistry, Volume 382, Issue 7, Pages 1071–1075, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2001.134.

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