Jump to ContentJump to Main Navigation
Show Summary Details

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred

12 Issues per year

IMPACT FACTOR 2015: 2.710
Rank 142 out of 289 in category Biochemistry & Molecular Biology in the 2015 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2015: 1.607
Source Normalized Impact per Paper (SNIP) 2015: 0.751
Impact per Publication (IPP) 2015: 2.609

See all formats and pricing
Volume 382, Issue 7 (Jul 2001)


The Extracellular Signal-Regulated Protein Kinases Erk1/Erk2 Stimulate Expression and Biological Activity of the Transcriptional Regulator Egr-1

Katrin Kaufmann / Karl Bach / Gerald Thiel
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/BC.2001.135


The zinc finger protein early growth response 1 (Egr 1) is a transcriptional activator involved in the regulation of growth and differentiation. We show here that a constitutive active mutant of mitogenactivated kinase kinase-1 (MAPKK-1) strongly stimulates the activity of the Egr-1 promoter, thus explaining the effects of mitogens upon Egr-1 mRNA and protein levels. Moreover, we show that a constitutive active MAPKK-1 leads to an increase in the biological activity of Egr-1 to activate transcription. We conclude that the signaling pathway involving mitogenactivated protein kinase/extracellular signalregulated protein kinase has a dual impact on the biology of Egr-1 by controlling the transcription of the Egr-1 gene and the transcriptional activity of the Egr-1 protein.

About the article

Published Online: 2005-06-01

Published in Print: 2001-07-20

Citation Information: Biological Chemistry, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2001.135. Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Gerald Thiel, Isabelle Müller, and Oliver G. Rössler
Molecular and Cellular Endocrinology, 2014, Volume 388, Number 1-2, Page 10
Antje Banning, Christian R.A. Regenbrecht, and Ritva Tikkanen
Cellular Signalling, 2014, Volume 26, Number 2, Page 198
Z. Li, M. Szabolcs, J. D. Terwilliger, and A. Efstratiadis
Carcinogenesis, 2006, Volume 27, Number 5, Page 1054
J Park and J E Schwarzbauer
Oncogene, 2014, Volume 33, Number 13, Page 1649
Werner Windischhofer, Evelyn Huber, Christine Rossmann, Michaela Semlitsch, Kerstin Kitz, Anamaria Rauh, Trevor Devaney, Hans-Jörg Leis, and Ernst Malle
Biochimie, 2012, Volume 94, Number 9, Page 1997
Inge Bauer, Mathias Hohl, Alia Al-Sarraj, Charles Vinson, and Gerald Thiel
Archives of Biochemistry and Biophysics, 2005, Volume 438, Number 1, Page 36
Pia Bartholomä, Nina Erlandsson, Katrin Kaufmann, Oliver G. Rössler, Bernd Baumann, Thomas Wirth, Klaus M. Giehl, and Gerald Thiel
Biochemical Pharmacology, 2002, Volume 63, Number 8, Page 1507
Siyuan Zheng, Milan G. Chheda, and Roel G.W. Verhaak
The Cancer Journal, 2012, Volume 18, Number 1, Page 107
Shu-Yuan Cheng, Lidia I. Serova, Dina Glazkova, and Esther L. Sabban
Brain Research, 2008, Volume 1193, Page 1
Christina Vock, Mareike Gleissner, Maja Klapper, and Frank Döring
Nutrition Research, 2008, Volume 28, Number 10, Page 681
Ariel Quiñones, Karl U Dobberstein, and Nikolai G Rainov
Life Sciences, 2003, Volume 72, Number 26, Page 2975
A. Buchwalter, C. Van Dort, S. Schultz, R. Smith, I.P. Le, J.L. Abbott, E. Oosterhouse, A.E. Johnson, F. Hansen-Smith, and M. Burnatowska-Hledin
Microvascular Research, 2008, Volume 75, Number 2, Page 155
Hong Geun Park, Se Hyun Kim, Han Soo Kim, Yong Min Ahn, Ung Gu Kang, and Yong Sik Kim
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2011, Volume 35, Number 4, Page 1014
Myung-Jun Kim, Jung-Hoon Kang, Seo-Yoon Chang, Hyun-Jong Jang, Gyeong Ryul Ryu, Seung Hyun Ko, In-Kyung Jeong, Myung-Suk Kim, and Yang-Hyeok Jo
Journal of Cellular Biochemistry, 2008, Volume 104, Number 6, Page 2261
Seung-Ho Baik, Bo-Keun Jee, Jin-Soo Choi, Hyoung-Kyu Yoon, Kweon-Haeng Lee, Yeul-Hong Kim, and Young Lim
Molecular Biology Reports, 2009, Volume 36, Number 7, Page 1767
Anders I. Persson, Cecilia Bull, and Peter S. Eriksson
European Journal of Neuroscience, 2006, Volume 23, Number 9, Page 2277
Anita C. Hansson, Roberto Rimondini, Olga Neznanova, Wolfgang H. Sommer, and Markus Heilig
European Journal of Neuroscience, 2008, Volume 27, Number 8, Page 1912
Jernej Kristl, Petra Slanc, Metka Krašna, Aleš Berlec, Matjaž Jeras, and Borut Štrukelj
Pharmaceutical Research, 2008, Volume 25, Number 3, Page 521
Stefan Grotegut, Dietrich von Schweinitz, Gerhard Christofori, and François Lehembre
The EMBO Journal, 2006, Volume 25, Number 15, Page 3534
Jeremy R Stuart, Hidehiko Kawai, Kelvin K C Tsai, Eric Y Chuang, and Zhi-Min Yuan
Oncogene, 2005
Heather Dziema, Ben Oatis, Greg Q. Butcher, Robert Yates, Kari R. Hoyt, and Karl Obrietan
European Journal of Neuroscience, 2003, Volume 17, Number 8, Page 1617
Alia Al-Sarraj, Regina M. Day, and Gerald Thiel
Journal of Cellular Biochemistry, 2005, Volume 94, Number 1, Page 153
Gerald Thiel and Giuseppe Cibelli
Journal of Cellular Physiology, 2002, Volume 193, Number 3, Page 287
Giuseppe Cibelli, Vincenza Policastro, Oliver G. R�ssler, and Gerald Thiel
Journal of Neuroscience Research, 2002, Volume 67, Number 4, Page 450

Comments (0)

Please log in or register to comment.
Log in