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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred

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Volume 382, Issue 9 (Sep 2001)


Specific Nucleoprotein Complexes within Adenovirus Capsids

T. Dobner / D. Büchner / T. Zeller / H. Wolf / H.H. Niller
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/BC.2001.169


Adenoviral DNA was examined within capsids by dimethyl sulfate footprinting. ProteinDNA interactions were visualized through ligationmediated PCR (LMPCR). Signals for protein binding were found adjacent to both inverted terminal repeats (ITR). There were no indications of close protein binding at several other loci of the viral genome. Therefore, adenovirus type 5 seems to contain sequence or locusspecific DNA binding proteins within the virion.

About the article

Published Online: 2005-06-01

Published in Print: 2001-09-30

Citation Information: Biological Chemistry, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2001.169. Export Citation

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