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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

IMPACT FACTOR 2018: 3.014
5-year IMPACT FACTOR: 3.162

CiteScore 2018: 3.09

SCImago Journal Rank (SJR) 2018: 1.482
Source Normalized Impact per Paper (SNIP) 2018: 0.820

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Volume 383, Issue 1


Nervous System Pathology: The Fibrin Perspective

Katerina Akassoglou / Sidney Strickland
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/BC.2002.004


Studies of extracellular matrix (ECM) biology in the nervous system have mainly focused on laminin, fibronectin and tenascinR, proteins that are present during nervous system development and normal function. However, during disease, fibrin, which physiologically is not present in the nervous tissue, is detected at nervous tissue lesions. This review summarizes evidence that correlates fibrin deposition with neuropathology and presents recent findings on cellular mechanisms and intracellular signaling pathways regulated by fibrin that might contribute to nervous system disease.

About the article

Published Online: 2005-06-01

Published in Print: 2002-01-23

Citation Information: Biological Chemistry, Volume 383, Issue 1, Pages 37–45, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2002.004.

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