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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

IMPACT FACTOR 2018: 3.014
5-year IMPACT FACTOR: 3.162

CiteScore 2018: 3.09

SCImago Journal Rank (SJR) 2018: 1.482
Source Normalized Impact per Paper (SNIP) 2018: 0.820

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Volume 383, Issue 1


Osteopontin Modulates Prostate Carcinoma Invasive Capacity through RGD-Dependent Upregulation of Plasminogen Activators

Adriano Angelucci / Claudio Festuccia / Gabriele DAndrea / Anna Teti / Mauro Bologna
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/BC.2002.024


Osteopontin, a noncollageneous bone matrix protein, is produced in several human tumors but its role in cancer progression has been only partially elucidated. In this study we investigated the potential role of osteopontin in the malignancy of prostate cancer cells. Chemotaxis and chemoinvasion analyses revealed a dosedependent increase in PC3 cell movement induced by osteopontin and a strict dependence of cell invasion on αvβ3 integrin function. The pattern of protease expression was modified by osteopontin and was characterized by an upregulation of plasminogen activators. Our findings suggest that osteopontin may confer selective malignant potential to prostate cancer cells through the enhancement of their invasive and proteolytic capability.

About the article

Published Online: 2005-06-01

Published in Print: 2002-01-23

Citation Information: Biological Chemistry, Volume 383, Issue 1, Pages 229–234, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2002.024.

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