Jump to ContentJump to Main Navigation
Show Summary Details

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred

12 Issues per year


IMPACT FACTOR 2015: 2.710
Rank 142 out of 289 in category Biochemistry & Molecular Biology in the 2015 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2015: 1.607
Source Normalized Impact per Paper (SNIP) 2015: 0.751
Impact per Publication (IPP) 2015: 2.609

Online
ISSN
1437-4315
See all formats and pricing
Volume 383, Issue 10 (Oct 2002)

Issues

In the Cellular Garden of Forking Paths: How p38 MAPKs Signal for Downstream Assistance

Y. Shi / M. Gaestel
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/BC.2002.173

Abstract

Mitogenactivated protein kinases (MAPKs) are evolutionarily conserved enzymes which connect cellsurface receptors to regulatory targets within cells and convert receptor signals into various outputs. In mammalian cells, four distinct MAPKs have been identified: the extracellular signalrelated kinases (ERK)-1/2, the cjun Nterminal kinases or stressactivated protein kinases 1 (JNK1/2/3, or SAPK1s), the p38 MAPKs (p38 α/β/γ/δ, or SAPK2s), and the ERK5 or big MAP kinase 1 (BMK1). The p38 MAPK cascade is activated by stress or cytokines and leads to phosphorylation of its central elements, the p38 MAPKs. Downstream of p38 MAPKs there is a diversification and extensive branching of signalling pathways. For that reason, we will focus in this review on the different signalling events that are triggered by p38 activity, and analyse how these events contribute to specific gene expression and cellular responses.

About the article

Published Online: 2005-06-01

Published in Print: 2002-10-06


Citation Information: Biological Chemistry, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2002.173. Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Yingxi Xu, Na Li, Rong Xiang, and Peiqing Sun
Trends in Biochemical Sciences, 2014, Volume 39, Number 6, Page 268
[2]
Italo Mario Cesari, Erika Carvalho, Mariana Figueiredo Rodrigues, Bruna dos Santos Mendonça, Nivea Dias Amôedo, and Franklin David Rumjanek
International Journal of Cell Biology, 2014, Volume 2014, Page 1
[3]
Hui Zheng, Alim Seit-Nebi, Xuemei Han, Aaron Aslanian, John Tat, Rong Liao, John R. Yates, and Peiqing Sun
Molecular Cell, 2013, Volume 50, Number 5, Page 699
[4]
E. Rudolf, V. Kralova, K. Rudolf, and S. John
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2013, Volume 741-742, Page 27
[5]
Takashi Kondo, Jun Sakurai, Hiroto Miwa, and Koichi Noguchi
NeuroReport, 2013, Volume 24, Number 2, Page 68
[6]
Netanel Tzarum, Yael Eisenberg-Domovich, Joell J. Gills, Phillip A. Dennis, and Oded Livnah
Journal of Molecular Biology, 2012, Volume 424, Number 5, Page 339
[7]
Sônia A. L. Corrêa and Katherine L. Eales
Journal of Signal Transduction, 2012, Volume 2012, Page 1
[8]
Mark William Lopes, Flávia Mahatma Schneider Soares, Nelson de Mello, Jean Costa Nunes, Fabiano Mendes de Cordova, Roger Walz, and Rodrigo Bainy Leal
Neurochemical Research, 2012, Volume 37, Number 9, Page 1868
[9]
Yvonne M. Yannoni, Matthias Gaestel, and Lih-Ling Lin
FEBS Letters, 2004, Volume 564, Number 1-2, Page 205
[10]
Netanel Tzarum, Ron Diskin, David Engelberg, and Oded Livnah
Journal of Molecular Biology, 2011, Volume 405, Number 5, Page 1154
[11]
Ulla Jalonen, Aleksi Lahti, Riku Korhonen, Hannu Kankaanranta, and Eeva Moilanen
Biochemical Pharmacology, 2005, Volume 69, Number 5, Page 733
[12]
Nguyen Xuan Nhiem, Vu Kim Thu, Phan Van Kiem, Chau Van Minh, Bui Huu Tai, Tran Hong Quang, Nguyen Xuan Cuong, Pham Hai Yen, Hye-Jin Boo, Jung-Il Kang, Hee-Kyoung Kang, and Young Ho Kim
Archives of Pharmacal Research, 2012, Volume 35, Number 1, Page 19
[13]
Michal Avitzour, Ron Diskin, Bilha Raboy, Nadav Askari, David Engelberg, and Oded Livnah
FEBS Journal, 2007, Volume 274, Number 4, Page 963
[14]
Matthäus Getlik, Christian Grütter, Jeffrey R. Simard, Hoang D. Nguyen, Armin Robubi, Beate Aust, Willem A.L. van Otterlo, and Daniel Rauh
European Journal of Medicinal Chemistry, 2012, Volume 48, Page 1
[15]
Raquel Ferreira, Tiago Santos, Michelle Viegas, Luísa Cortes, Liliana Bernardino, Otília V Vieira, and João O Malva
Journal of Neuroinflammation, 2011, Volume 8, Number 1, Page 169
[16]
Tania Benatar, Wenyi Yang, Yutaka Amemiya, Valentina Evdokimova, Harriette Kahn, Claire Holloway, and Arun Seth
Breast Cancer Research and Treatment, 2012, Volume 133, Number 2, Page 563
[17]
Devki Sukhtankar, Alec Okun, Anupama Chandramouli, Mark A Nelson, Todd W Vanderah, Anne E Cress, Frank Porreca, and Tamara King
Molecular Pain, 2011, Volume 7, Number 1, Page 81
[18]
Koichi Obata and Koichi Noguchi
Neuroscience Research, 2006, Volume 55, Number 1, Page 1
[19]
Hiroki Imbe, Keiichiro Okamoto, Fumiko Aikawa, Akihisa Kimura, Tomohiro Donishi, Yasuhiko Tamai, Yasutomo Iwai-Liao, and Emiko Senba
Brain Research, 2007, Volume 1134, Page 131
[21]
Wei Yu, Masahiro Akishita, Hang Xi, Kumiko Nagai, Noriko Sudoh, Hiroshi Hasegawa, Koichi Kozaki, and Kenji Toba
Clinica Chimica Acta, 2006, Volume 364, Number 1-2, Page 328
[22]
Margarida Ressurreição, David Rollinson, Aidan M. Emery, and Anthony J. Walker
Molecular and Biochemical Parasitology, 2011, Volume 180, Number 1, Page 51
[23]
Hee-Sae Park, Jung-Soon Mo, and Eui-Ju Choi
Biochemical and Biophysical Research Communications, 2006, Volume 351, Number 1, Page 281
[24]
Koichi Obata and Koichi Noguchi
Life Sciences, 2004, Volume 74, Number 21, Page 2643
[25]
S. Bendfeldt, J.F. Ridpath, and J.D. Neill
Virus Research, 2007, Volume 126, Number 1-2, Page 96
[26]
Antonio Garrido Montalban, Erik Boman, Chau-Dung Chang, Susana Conde Ceide, Russell Dahl, David Dalesandro, Nancy G.J. Delaet, Eric Erb, Justin Ernst, Andrew Gibbs, Jeffrey Kahl, Linda Kessler, Jan Lundström, Stephen Miller, Hiroshi Nakanishi, Edward Roberts, Eddine Saiah, Robert Sullivan, Zhijun Wang, and Christopher J. Larson
European Journal of Pharmacology, 2010, Volume 632, Number 1-3, Page 93
[27]
Nguyen Huu Tung, Gyu Yong Song, Jeong-Ah Kim, Jae-Hee Hyun, Hee-Kyoung Kang, and Young Ho Kim
Bioorganic & Medicinal Chemistry Letters, 2010, Volume 20, Number 1, Page 309
[28]
Elena López, Isabel López, Julia Sequí, and Antonio Ferreira
Journal of Clinical Bioinformatics, 2011, Volume 1, Number 1, Page 16
[29]
Olivier Kassel and Peter Herrlich
Molecular and Cellular Endocrinology, 2007, Volume 275, Number 1-2, Page 13
[30]
Ilana Méchaly, Steeve Bourane, David Piquemal, Mohammed Al-Jumaily, Stéphanie Ventéo, Sylvie Puech, Frédérique Scamps, Jean Valmier, and Patrick Carroll
Molecular and Cellular Neuroscience, 2006, Volume 32, Number 3, Page 217
[31]
[32]
Andreas Behren, Konrad Binder, Goran Vucelic, Stephan Herberhold, Bernhard Hirt, Hubert Loewenheim, Serena Preyer, Hans Peter Zenner, and Christian Simon
Experimental Cell Research, 2005, Volume 303, Number 2, Page 321
[34]
Lee-Anne Stanton, T.Michael Underhill, and Frank Beier
Developmental Biology, 2003, Volume 263, Number 2, Page 165
[35]
Justin A. MacDonald and Kenneth B. Storey
The International Journal of Biochemistry & Cell Biology, 2005, Volume 37, Number 3, Page 679
[36]
Toshiyuki Mizushima, Koichi Obata, Hiroki Yamanaka, Yi Dai, Tetsuo Fukuoka, Atsushi Tokunaga, Takashi Mashimo, and Koichi Noguchi
Pain, 2005, Volume 113, Number 1, Page 51
[37]
Jiahuai Han and Peiqing Sun
Trends in Biochemical Sciences, 2007, Volume 32, Number 8, Page 364
[38]
Maria Buxadé, Josep L. Parra, Simon Rousseau, Natalia Shpiro, Rodolfo Marquez, Nick Morrice, Jenny Bain, Enric Espel, and Christopher G. Proud
Immunity, 2005, Volume 23, Number 2, Page 177
[39]
Carlos Rossa, Kathryn Ehmann, Min Liu, Chetan Patil, and Keith L. Kirkwood
Journal of Interferon & Cytokine Research, 2006, Volume 26, Number 10, Page 719
[40]
Jeremy L. Herrmann, Troy A. Markel, Aaron M. Abarbanell, Brent R. Weil, Meijing Wang, Yue Wang, Jiangning Tan, and Daniel R. Meldrum
Antioxidants & Redox Signaling, 2009, Volume 11, Number 8, Page 1883
[41]
Tomoshige Kino, James H Segars, and George P Chrousos
Expert Review of Endocrinology & Metabolism, 2010, Volume 5, Number 4, Page 603
[42]
Guoyan Wang and Frank Beier
Journal of Bone and Mineral Research, 2005, Volume 20, Number 6, Page 1022
[43]
Ana Cuadrado and Angel R. Nebreda
Biochemical Journal, 2010, Volume 429, Number 3, Page 403
[45]
Chia-Cheng Wu, Xiaohua Wu, Jiahuai Han, and Peiqing Sun
Protein & Cell, 2010, Volume 1, Number 6, Page 573
[46]
Nguyen Huu Tung, Jeong-Hyun Son, Kyoungwon Cho, Jeong-Ah Kim, Jae-Hee Hyun, Hee-Kyoung Kang, Gyu Yong Song, Chun Jung Park, and Young Ho Kim
Food Science and Biotechnology, 2010, Volume 19, Number 1, Page 271
[47]
Bethany L. Fitzsimmons, Michela Zattoni, Camilla I. Svensson, Joanne Steinauer, Xiao-Ying Hua, and Tony L. Yaksh
NeuroReport, 2010, Volume 21, Number 4, Page 313
[48]
[49]
Jae-Hee Hyun, Sang-Cheol Kim, Jung-Il Kang, Min-Kyoung Kim, Hye-Jin Boo, Jung-Mi Kwon, Young-Sang Koh, Jin-Won Hyun, Deok-Bae Park, Eun-Sook Yoo, and Hee-Kyoung Kang
Biological & Pharmaceutical Bulletin, 2009, Volume 32, Number 10, Page 1760
[50]
Jill Roberts, Michael H. Ossipov , and Frank Porreca
European Journal of Neuroscience, 2009, Volume 30, Number 2, Page 229
[51]
Amy L. Paguirigan and David J. Beebe
Integrative Biology, 2009, Volume 1, Number 2, Page 182
[52]
Xiao-Ying Hua, Camilla I. Svensson, Tomohiro Matsui, Bethany Fitzsimmons, Tony L. Yaksh, and Michael Webb
European Journal of Neuroscience, 2005, Volume 22, Number 10, Page 2431
[53]
Brent E. Bobick and William M. Kulyk
Birth Defects Research Part C: Embryo Today: Reviews, 2008, Volume 84, Number 2, Page 131
[54]
Min-Chul Seo, Sangseop Kim, Sang-Hyun Kim, Long Tai Zheng, Eui Kyun Park, Won-Ha Lee, and Kyoungho Suk
Journal of Neuroscience Research, 2008, Volume 86, Number 5, Page 1087
[55]
A. White, C. A. Pargellis, J. M. Studts, B. G. Werneburg, and B. T. Farmer
Proceedings of the National Academy of Sciences, 2007, Volume 104, Number 15, Page 6353
[56]
Gudrun Ulrich-Merzenich, Heike Zeitler, Darius Panek, Dirk Bokemeyer, and Hans Vetter
European Journal of Nutrition, 2007, Volume 46, Number 2, Page 87
[57]
Dagmar Faust, Ignacio Dolado, Ana Cuadrado, Franz Oesch, Carsten Weiss, Angel R Nebreda, and Cornelia Dietrich
Oncogene, 2005, Volume 24, Number 53, Page 7941
[58]
David W. Powell, William M. Pierce, and Kenneth R. McLeish
Mass Spectrometry Reviews, 2005, Volume 24, Number 6, Page 847
[59]
Jennifer Y. Kong, Shaun S. Klassen, and Simon W. Rabkin
Molecular and Cellular Biochemistry, 2005, Volume 278, Number 1-2, Page 39
[60]
Arianna L. Kim, Jeffrey M. Labasi, Yucui Zhu, Xiuwei Tang, Kim McClure, Christopher A. Gabel, Mohammad Athar, and David R. Bickers
Journal of Investigative Dermatology, 2005, Volume 124, Number 6, Page 1318
[61]
Olga Sokolova, Nicole Heppel, Ruth Jagerhuber, Kwang Sik Kim, Matthias Frosch, Martin Eigenthaler, and Alexandra Schubert-Unkmeir
Cellular Microbiology, 2004, Volume 6, Number 12, Page 1153

Comments (0)

Please log in or register to comment.
Log in