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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

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Volume 383, Issue 10 (Oct 2002)


The TNFTNF Receptor System

T. Hehlgans / D.N. Männel
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/BC.2002.178


Different forms of tumor necrosis factor (TNF) interact with two specific receptors for TNF (TNFR) on the cell membrane to induce a variety of effects. While sharing structural similarities in their extracellular domains, the two TNFRs differ in their intracellular domain, their signal transduction, and consequently their function. In addition, one of the two TNFRs can be expressed in two differently located isoforms. This makes the TNFTNFR system very complex. The dual TNF function for either cell death or survival upon interaction of members of the TNF ligand family with members of the TNF receptor family will be discussed.

About the article

Published Online: 2005-06-01

Published in Print: 2002-10-06

Citation Information: Biological Chemistry, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2002.178. Export Citation

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