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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred


IMPACT FACTOR 2017: 3.022

CiteScore 2017: 2.81

SCImago Journal Rank (SJR) 2017: 1.562
Source Normalized Impact per Paper (SNIP) 2017: 0.705

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1437-4315
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Volume 383, Issue 12

Issues

Processing and Activation of Lysosomal Proteinases

K. Ishidoh / E. Kominami
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/BC.2002.206

Abstract

Lysosomal proteinases are translated as preproenzymes, transferred through the Golgi apparatus as proenzymes, and localized in lysosomes as the mature enzymes. Pulsechase analyses and the immunoisolation of proenzymes or recombinant proenzymes are useful tools for analyzing this process, but the processing proteinases that participate in this pathway are largely unknown. Recently, we developed a new method for analyzing processing proteinases using Bafilomycin A1 and proteinase inhibitors. Here we summarize the recent progress including our results obtained using this method.

About the article

Published Online: 2005-06-01

Published in Print: 2002-12-09


Citation Information: Biological Chemistry, Volume 383, Issue 12, Pages 1827–1831, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2002.206.

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