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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred


IMPACT FACTOR 2018: 3.014
5-year IMPACT FACTOR: 3.162

CiteScore 2018: 3.09

SCImago Journal Rank (SJR) 2018: 1.482
Source Normalized Impact per Paper (SNIP) 2018: 0.820

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1437-4315
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Volume 383, Issue 12

Issues

Evidence for the Involvement of the Unique C-Tail of S100A9 in the Binding of Arachidonic Acid to the Heterocomplex S100A8/A9

C. Sopalla / N. Leukert / C. Sorg / C. Kerkhoff
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/BC.2002.213

Abstract

Protein complexes formed by S100A8 and S100A9 represent the only AAbinding capacity in the human neutrophilic cytosol and are involved in the intracellular arachidonic acid metabolism. The formation of S100A8/A9 protein complexes and the binding of calcium to the complexes are prerequisites for the specific binding of polyunsaturated fatty acids. The present study was undertaken to characterize the fatty acid binding site within the protein complex. Deletions at both termini and point mutations of different basic amino acids especially within the extended Cterminal tail of human S100A9 were introduced. The S100A9 mutant proteins were then analyzed with respect to proteinprotein interaction (GST pull downassay and yeast twohybrid system) and functional properties (arachidonic acid and calcium binding). The data give strong evidence that the unique Ctail of S100A9 containing the three consecutive histidine residues (His103-His105) represents the region to which the fatty acid carboxygroup is bound to the protein complex. The localization of the AAbinding site within the unique Ctail of S100A9 correlates with the fact that fatty acid binding has not yet been reported for other S100 proteins.

About the article

Published Online: 2005-06-01

Published in Print: 2002-12-09


Citation Information: Biological Chemistry, Volume 383, Issue 12, Pages 1895–1905, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2002.213.

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