Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

12 Issues per year

IMPACT FACTOR 2016: 3.273

CiteScore 2016: 3.01

SCImago Journal Rank (SJR) 2016: 1.679
Source Normalized Impact per Paper (SNIP) 2016: 0.800

See all formats and pricing
More options …
Volume 383, Issue 2


TCF: Lady Justice Casting the Final Verdict on the Outcome of Wnt Signalling

H. Brantjes / N. Barker / J. van Es / H. Clevers
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/BC.2002.027


The Wnt signalling cascade plays an important role during embryonic patterning and cell fate determination and is highly conserved throughout evolution. Factors of the TCF/LEF HMG domain family (Tcfs) are the downstream effectors of this signal transduction pathway. Upon Wnt signalling, a cascade is initiated that results in the translocation of βcatenin to the nucleus, where it interacts with Tcf to generate a transcriptionally active complex. This bipartite transcription factor is targeted to the upstream regulatory regions of Tcf target genes. In the absence of Wnt signals, βcatenin is degraded in the cytoplasm via the ubiquitinproteasome pathway. Several proteins are instrumental in achieving this tight regulation of βcatenin levels in the cell, including adenomatous polyposis coli (APC), GSK3 β, and Axin/Conductin. Deregulation of the Wnt signalling pathway is implicated in several forms of cancer, such as colon carcinoma and melanoma. This deregulation is achieved via mutation of APC, βcatenin or Axin, resulting in elevated βcatenin levels and the presence of constitutively active Tcfβcatenin complexes in the nucleus. The accompanying inappropriate activation of target genes is considered to be a critical, early event in this carcinogenesis. In addition to regulating βcatenin levels, normal healthy cells have evolved a second level of regulation, by manipulating the activity of the Tcf proteins themselves. In the absence of Wnt signalling, Tcf complexes with several transcriptional repressor proteins ensuring active repression of Tcf target genes. In this review the dual role of Tcf proteins in the Wnt signalling cascade will be discussed.

About the article

Published Online: 2005-06-01

Published in Print: 2002-02-15

Citation Information: Biological Chemistry, Volume 383, Issue 2, Pages 255–261, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2002.027.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Tatiana Goretsky, Emily M. Bradford, Qing Ye, Olivia F. Lamping, Tomas Vanagunas, Mary Pat Moyer, Patrick C. Keller, Preetika Sinh, Josep M. Llovet, Tianyan Gao, Qing-Bai She, Linheng Li, and Terrence A. Barrett
Scientific Reports, 2018, Volume 8, Number 1
Alda Vidrich, Jenny M. Buzan, Brooks Brodrick, Chibuzo Ilo, Leigh Bradley, Kirstin Skaar Fendig, Thomas Sturgill, and Steven M. Cohn
American Journal of Physiology-Gastrointestinal and Liver Physiology, 2009, Volume 297, Number 1, Page G168
Audra L. Andrew, Daren C. Card, Robert P. Ruggiero, Drew R. Schield, Richard H. Adams, David D. Pollock, Stephen M. Secor, and Todd A. Castoe
Physiological Genomics, 2015, Volume 47, Number 5, Page 147
Hoeke A. Baarsma, Mark H. Menzen, Andrew J. Halayko, Herman Meurs, Huib A. M. Kerstjens, and Reinoud Gosens
American Journal of Physiology-Lung Cellular and Molecular Physiology, 2011, Volume 301, Number 6, Page L956
Julia Beisner, Zora Teltschik, Maureen J. Ostaff, Machteld M. Tiemessen, Frank J. T. Staal, Guoxing Wang, Michael Gersemann, Gori Perminow, Morten H. Vatn, Matthias Schwab, Eduard F. Stange, and Jan Wehkamp
American Journal of Physiology-Gastrointestinal and Liver Physiology, 2014, Volume 307, Number 5, Page G487
Bob Y Liu, Young Chul Kim, Vicki Leatherberry, Pam Cowin, and Caroline M Alexander
Oncogene, 2003, Volume 22, Number 58, Page 9243
M Oren
Cell Death & Differentiation, 2003, Volume 10, Number 4, Page 431
Oncology Reports, 2014, Volume 31, Number 1, Page 397
Colin Jamora, Ramanuj DasGupta, Pawel Kocieniewski, and Elaine Fuchs
Nature, 2003, Volume 422, Number 6929, Page 317
Bau-Lin Huang, Sean M. Brugger, and Karen M. Lyons
Journal of Biological Chemistry, 2010, Volume 285, Number 36, Page 27702
Yong Zhang, LingLing Toh, Peishan Lau, and Xueying Wang
Journal of Biological Chemistry, 2012, Volume 287, Number 39, Page 32494
Tatiana Goretsky, Emily M. Bradford, Hyunji Ryu, Maryam Tahir, Mary Pat Moyer, Tianyan Gao, Linheng Li, and Terrence A. Barrett
Journal of Biological Chemistry, 2016, Volume 291, Number 8, Page 4166
Lillian Ouko, Thomas R. Ziegler, Li H. Gu, Leonard M. Eisenberg, and Vincent W. Yang
Journal of Biological Chemistry, 2004, Volume 279, Number 25, Page 26707
Florian Plattner, Marco Angelo, and K. Peter Giese
Journal of Biological Chemistry, 2006, Volume 281, Number 35, Page 25457
Rachel A. Kahler and Jennifer J. Westendorf
Journal of Biological Chemistry, 2003, Volume 278, Number 14, Page 11937
Ya He, Peng-Zhi Zhang, Dong Sun, Wen-Juan Mi, Xin-Yi Zhang, Yong Cui, Xing-Wang Jiang, Xiao-Bo Mao, and Jian-Hua Qiu
Cell Transplantation, 2014, Volume 23, Number 6, Page 747
Hua He, Ajay E. Kuriyan, Chen-Wei Su, Megha Mahabole, Yuan Zhang, Ying-Ting Zhu, Harry W. Flynn, Jean-Marie Parel, and Scheffer C. G. Tseng
Scientific Reports, 2017, Volume 7, Page 43736
Zhongyou Que, Ping Wang, Yi Hu, Yixue Xue, Xiaobai Liu, Chengbin Qu, Jun Ma, and Yunhui Liu
Pharmacological Research, 2017, Volume 119, Page 72
Hélder S. C. Barbosa, Tiago G. Fernandes, Tiago P. Dias, Maria Margarida Diogo, Joaquim M. S. Cabral, and Austin John Cooney
PLoS ONE, 2012, Volume 7, Number 6, Page e38963
Hilary C. Archbold, Chris Broussard, Mikyung V. Chang, Ken M. Cadigan, and Gregory S. Barsh
PLoS Genetics, 2014, Volume 10, Number 9, Page e1004591
Jianming Wu, Maureen H. Richards, Jinhai Huang, Lena Al-Harthi, Xiulong Xu, Rui Lin, Fenglong Xie, Andrew W. Gibson, Jeffrey C. Edberg, Robert P. Kimberly, and Cara Gottardi
PLoS ONE, 2011, Volume 6, Number 10, Page e26143
Maria Sirakov, Seham Skah, Imtiaz Nisar Lone, Julien Nadjar, Dimitar Angelov, Michelina Plateroti, and Masaru Katoh
PLoS ONE, 2012, Volume 7, Number 4, Page e34162
Aleksander Skardal, Mahesh Devarasetty, Steven Forsythe, Anthony Atala, and Shay Soker
Biotechnology and Bioengineering, 2016, Volume 113, Number 9, Page 2020
Anja Kafka, Davor Tomas, Vili Beroš, Hrvoje Pećina, Martina Zeljko, and Nives Pećina-Šlaus
International Journal of Molecular Sciences, 2014, Volume 15, Number 6, Page 10635
B C Valdez, J E Brammer, Y Li, D Murray, Y Liu, C Hosing, Y Nieto, R E Champlin, and B S Andersson
Blood Cancer Journal, 2015, Volume 5, Number 10, Page e357
Hui Zhang, Jing Xue, Mingjiang Li, Xingbo Zhao, Deying Wei, and Changzhong Li
Molecular and Cellular Endocrinology, 2015, Volume 413, Page 61
Kailiang Zhang, Junxia Zhang, Lei Han, Peiyu Pu, and Chunsheng Kang
Journal of Neuroimmune Pharmacology, 2012, Volume 7, Number 4, Page 740
Qiubo Lei, Yongsu Jeong, Kamana Misra, Shike Li, Alice K. Zelman, Douglas J. Epstein, and Michael P. Matise
Developmental Cell, 2006, Volume 11, Number 3, Page 325
Markus Affolter, George Pyrowolakis, Alexander Weiss, and Konrad Basler
Developmental Cell, 2008, Volume 15, Number 1, Page 11
Ambrose R. Kidd, Jennifer A. Miskowski, Kellee R. Siegfried, Hitoshi Sawa, and Judith Kimble
Cell, 2005, Volume 121, Number 5, Page 761
Aleksander Skardal, Mahesh Devarasetty, Christopher Rodman, Anthony Atala, and Shay Soker
Annals of Biomedical Engineering, 2015, Volume 43, Number 10, Page 2361
Qiong Shi, Xu Song, Jun Wang, Jia Gu, Weijian Zhang, Jinxia Hu, Xiuping Zhou, and Rutong Yu
Journal of Molecular Neuroscience, 2015, Volume 55, Number 1, Page 32
Donghao Shang, Rumei Bi, Tiandong Han, Daye Wang, Ye Tian, and Yuting Liu
Cancer Investigation, 2014, Volume 32, Number 7, Page 368
Kai Cui, Zu Yang, Hesham Darwish, Yuanyuan Zhang, Yaqiong Ge, Xiyue Zhang, Rongni Li, and Xuemei Deng
Gene, 2014, Volume 546, Number 2, Page 277
Lluís Nisa, Daniel Matthias Aebersold, Roland Giger, Yitzhak Zimmer, and Michaela Medová
Pharmacology & Therapeutics, 2014, Volume 143, Number 3, Page 337
Monika Buraczynska, Pawel Zukowski, Piotr Ksiazek, Agata Kuczmaszewska, Joanna Janicka, and Wojciech Zaluska
Molecular Biology Reports, 2014, Volume 41, Number 6, Page 4063
K. H. Emami, C. Nguyen, H. Ma, D. H. Kim, K. W. Jeong, M. Eguchi, R. T. Moon, J.-L. Teo, S. W. Oh, H. Y. Kim, S. H. Moon, J. R. Ha, and M. Kahn
Proceedings of the National Academy of Sciences, 2004, Volume 101, Number 34, Page 12682
J.-L. Teo, H. Ma, C. Nguyen, C. Lam, and M. Kahn
Proceedings of the National Academy of Sciences, 2005, Volume 102, Number 34, Page 12171
Philippe Blache, Marc van de Wetering, Isabelle Duluc, Claire Domon, Philippe Berta, Jean-Noël Freund, Hans Clevers, and Philippe Jay
The Journal of Cell Biology, 2004, Volume 166, Number 1, Page 37
Tamara Nikuševa-Martić, Ljiljana Šerman, Martina Zeljko, Željko Vidas, Slavko Gašparov, Hrvojka Marija Zeljko, Marin Kosović, and Nives Pećina-Šlaus
Pathology & Oncology Research, 2013, Volume 19, Number 3, Page 545
Chang Jin, Jing Chen, Qinghang Meng, Vinicius Carreira, Neville N.C. Tam, Esmond Geh, Saikumar Karyala, Shuk-Mei Ho, Xiangtian Zhou, Mario Medvedovic, and Ying Xia
Developmental Biology, 2013, Volume 374, Number 1, Page 96
Kum Hei Ryu, Ki-Nam Shim, Sung-Ae Jung, Kwon Yoo, Yang-Hee Joo, and Joo Ho Lee
The Korean Journal of Gastroenterology, 2012, Volume 60, Number 4, Page 229
F. Gu, H. Shi, L. Gao, H. Zhang, and Q. Tao
Acta Biochimica et Biophysica Sinica, 2012, Volume 44, Number 11, Page 939
S. Schrader, A. R. O'Callaghan, S. J. Tuft, M. Beaconsfield, G. Geerling, and J. T. Daniels
Journal of Tissue Engineering and Regenerative Medicine, 2014, Volume 8, Number 12, Page 969
Alessandro Piergentili, Fabio Del Bello, Francesco Gentili, Mario Giannella, Wilma Quaglia, Cristian Vesprini, Russell J. Thomas, and Graeme M. Robertson
Tetrahedron, 2007, Volume 63, Number 52, Page 12912
H. Doucas, G. Garcea, C.P. Neal, M.M. Manson, and D.P. Berry
European Journal of Cancer, 2005, Volume 41, Number 3, Page 365
Elizabeth Heeg-Truesdell and Carole LaBonne
Developmental Biology, 2006, Volume 298, Number 1, Page 71
Yongjun Yin, Andrew C. White, Sung-Ho Huh, Matthew J. Hilton, Hidemi Kanazawa, Fanxin Long, and David M. Ornitz
Developmental Biology, 2008, Volume 319, Number 2, Page 426
Premnath Shetty, Miao-Chia Lo, Scott M. Robertson, and Rueyling Lin
Developmental Biology, 2005, Volume 285, Number 2, Page 584
F.J. Lovicu and J.W. McAvoy
Developmental Biology, 2005, Volume 280, Number 1, Page 1
Lijoy K. Mathew, Michel T. Simonich, and Robert L. Tanguay
Biochemical Pharmacology, 2009, Volume 77, Number 4, Page 498
A.J. Quyn, R.J.C. Steele, F.A. Carey, and I.S. Näthke
The Surgeon, 2008, Volume 6, Number 6, Page 350
Ossia M. Eichhoff, Ashani Weeraratna, Marie C. Zipser, Laurence Denat, Daniel S. Widmer, Mai Xu, Lydia Kriegl, Thomas Kirchner, Lionel Larue, Reinhard Dummer, and Keith S. Hoek
Pigment Cell & Melanoma Research, 2011, Volume 24, Number 4, Page 631
Donghao Shang, Yuting Liu, Xiuhong Xu, Tiandong Han, and Ye Tian
Cancer Letters, 2011, Volume 311, Number 2, Page 230
Yoshiaki Kamei, Katsumi Kito, Takashi Takeuchi, Yoshinori Imai, Ryuichi Murase, Norifumi Ueda, Nobuaki Kobayashi, and Yasuhito Abe
Human Pathology, 2007, Volume 38, Number 8, Page 1273
Jaideep Behari, Tzu-Hsuan Yeh, Lindsay Krauland, Wade Otruba, Benjamin Cieply, Beth Hauth, Udayan Apte, Tong Wu, Rhobert Evans, and Satdarshan P.S. Monga
The American Journal of Pathology, 2010, Volume 176, Number 2, Page 744
Monika Buraczynska, Andrzej Swatowski, Dorota Markowska-Gosik, Agata Kuczmaszewska, and Andrzej Ksiazek
Diabetes Research and Clinical Practice, 2011, Volume 93, Number 3, Page 390
Maria V. Abramova, Evgeny A. Zatulovskiy, Svetlana B. Svetlikova, Alexander N. Kukushkin, and Valery A. Pospelov
Biochemical and Biophysical Research Communications, 2010, Volume 391, Number 1, Page 142
Haeyong Lee, Sungmin Bae, Kijeong Kim, Wonyong Kim, Sang-In Chung, Young Yang, and Yoosik Yoon
Life Sciences, 2011, Volume 88, Number 7-8, Page 294
Emma Hilton, Maria Rex, and Robert Old
Mechanisms of Development, 2003, Volume 120, Number 10, Page 1127
Hiroki Kobayashi, Tatsuo Michiue, Akira Yukita, Hiroki Danno, Kenji Sakurai, Akimasa Fukui, Akira Kikuchi, and Makoto Asashima
Mechanisms of Development, 2005, Volume 122, Number 10, Page 1138
Vassiliki Fotaki, David J. Price, and John O. Mason
The Journal of Comparative Neurology, 2011, Volume 519, Number 9, Page 1640
Olivera Stojadinovic, Harold Brem, Constantinos Vouthounis, Brian Lee, John Fallon, Michael Stallcup, Ankit Merchant, Robert D. Galiano, and Marjana Tomic-Canic
The American Journal of Pathology, 2005, Volume 167, Number 1, Page 59
Yan-Wei Ye, Jiang-Hong Wu, Chun-Meng Wang, Ye Zhou, Chun-Yan Du, Bi-Qiang Zheng, Xi Cao, Xiao-Yan Zhou, Meng-Hong Sun, and Ying-Qiang Shi
Cancer Letters, 2011, Volume 307, Number 2, Page 124
Scott M. Robertson, Miao-Chia Lo, Ranaan Odom, Xiao-Dong Yang, Jessica Medina, Shuyi Huang, and Rueyling Lin
Developmental Biology, 2011, Volume 355, Number 1, Page 115
Katayoon H. Emami and Eva Corey
Cancer Letters, 2007, Volume 253, Number 2, Page 170
Rolf Gebhardt, Alicja Baldysiak-Figiel, Vera Krügel, Elke Ueberham, and Frank Gaunitz
Progress in Histochemistry and Cytochemistry, 2007, Volume 41, Number 4, Page 201
Michael McMillan and Michael Kahn
Drug Discovery Today, 2005, Volume 10, Number 21, Page 1467
Daniel Kalderon
Trends in Cell Biology, 2002, Volume 12, Number 11, Page 523
Inke S. Näthke
Annual Review of Cell and Developmental Biology, 2004, Volume 20, Number 1, Page 337
Ricardo Armisén, Katherine Marcelain, Felipe Simon, Julio C. Tapia, Jessica Toro, Andrew F.G. Quest, and Andrés Stutzin
Journal of Cellular Physiology, 2011, Volume 226, Number 1, Page 103
Alexandra E. Gylfe, Johanna Sirkiä, Manuel Ahlsten, Heikki Järvinen, Jukka-Pekka Mecklin, Auli Karhu, and Lauri A. Aaltonen
International Journal of Cancer, 2010, Volume 127, Number 12, Page 2974
Maria S Tretiakova, Meer T Shabani-Rad, Kelly Guggisberg, John Hart, Robert A Anders, and Zu-hua Gao
Histopathology, 2010, Volume 56, Number 6, Page 683
De-Yuan Fu, Zhi-Min Wang, Li-Chen, Bei-Lan Wang, Zhen-Zhou Shen, Wei Huang, and Zhi-Ming Shao
Breast Cancer Research and Treatment, 2010, Volume 119, Number 3, Page 601
Ludmila Prokunina-Olsson, Cullan Welch, Ola Hansson, Neeta Adhikari, Laura J. Scott, Nicolle Usher, Maurine Tong, Andrew Sprau, Amy Swift, Lori L. Bonnycastle, Michael R. Erdos, Zhi He, Richa Saxena, Brennan Harmon, Olga Kotova, Eric P. Hoffman, David Altshuler, Leif Groop, Michael Boehnke, Francis S. Collins, and Jennifer L. Hall
Human Molecular Genetics, 2009, Volume 18, Number 20, Page 3795
Katayoon H. Emami, Lisha G. Brown, Tiffany E.M. Pitts, Xizhang Sun, Robert L. Vessella, and Eva Corey
The Prostate, 2009, Volume 69, Number 14, Page 1481
Qing Yu, Archna Sharma, Sun Young Oh, Hyung-Geun Moon, M Zulfiquer Hossain, Theresa M Salay, Karen E Leeds, Hansen Du, Beibei Wu, Marian L Waterman, Zhou Zhu, and Jyoti Misra Sen
Nature Immunology, 2009, Volume 10, Number 9, Page 992
T. Darlavoix, W. Seelentag, P. Yan, A. Bachmann, and F. T. Bosman
Virchows Archiv, 2009, Volume 454, Number 6, Page 629
Gabriela Pavlinkova, J. Michael Salbaum, and Claudia Kappen
Birth Defects Research Part A: Clinical and Molecular Teratology, 2008, Volume 82, Number 10, Page 710
Felice Giangaspero, Stefan Wellek, Jun Masuoka, Marco Gessi, Paul Kleihues, and Hiroko Ohgaki
Acta Neuropathologica, 2006, Volume 112, Number 1, Page 5
Michael D. Thompson and Satdarshan P. S. Monga
Hepatology, 2007, Volume 45, Number 5, Page 1298
Y Ji, S Shah, K Soanes, M N Islam, B Hoxter, S Biffo, T Heslip, and S Byers
Oncogene, 2008, Volume 27, Number 6, Page 755
Bradley W. Doble and James R. Woodgett
Cells Tissues Organs, 2007, Volume 185, Number 1-3, Page 73
M Shulewitz, I Soloviev, T Wu, H Koeppen, P Polakis, and C Sakanaka
Oncogene, 2006, Volume 25, Number 31, Page 4361
Alexander Roesch, Bernd Becker, Wulf Schneider-Brachert, Ilja Hagen, Michael Landthaler, and Thomas Vogt
Journal of Investigative Dermatology, 2006, Volume 126, Number 8, Page 1850
Frans M. van Roy and Pierre D. McCrea
Nature Reviews Cancer, 2005, Volume 5, Number 12, Page 956
Barbara K. Brott and Sergei Y. Sokol
Differentiation, 2005, Volume 73, Number 7, Page 323
Rolph Pfundt, Frank Smit, Corine Jansen, Tilly Aalders, Huub Straatman, Walter van der Vliet, John Isaacs, Ad Geurts van Kessel, and Jack Schalken
Genes, Chromosomes and Cancer, 2005, Volume 43, Number 3, Page 273
Ruth Schmidt-Ullrich and Ralf Paus
BioEssays, 2005, Volume 27, Number 3, Page 247
John J. Grzesiak, Kathy C. Smith, Douglas W. Burton, Leonard J. Deftos, and Michael Bouvet
International Journal of Cancer, 2005, Volume 114, Number 4, Page 522
Mohammad Ilyas
The Journal of Pathology, 2005, Volume 205, Number 2, Page 130
C.S. Young, T.N.H. Masckauchan, and Jan Kitajewski
Differentiation, 2003, Volume 71, Number 8, Page 477
Othman A. Mohamed, Hugh J. Clarke, and Daniel Dufort
Developmental Dynamics, 2004, Volume 231, Number 2, Page 416
Genevieve M. Boland, Geraldine Perkins, David J. Hall, and Rocky S. Tuan
Journal of Cellular Biochemistry, 2004, Volume 93, Number 6, Page 1210
Randall B. Widelitz, Ting Xin Jiang, Mingke Yu, Ted Shen, Jen-Yee Shen, Ping Wu, Zhicao Yu, and Cheng-Ming Chuong
Journal of Experimental Zoology, 2003, Volume 298B, Number 1, Page 109
Yoshihiro Edamoto, Akira Hara, Wojciech Biernat, Luigi Terracciano, Gieri Cathomas, Hans-Martin Riehle, Masanori Matsuda, Hideki Fujii, Jean-Yves Scoazec, and Hiroko Ohgaki
International Journal of Cancer, 2003, Volume 106, Number 3, Page 334

Comments (0)

Please log in or register to comment.
Log in