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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

12 Issues per year


IMPACT FACTOR 2016: 3.273

CiteScore 2017: 2.81

SCImago Journal Rank (SJR) 2017: 1.562
Source Normalized Impact per Paper (SNIP) 2017: 0.705

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1437-4315
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Volume 383, Issue 3-4

Issues

The Pathobiochemistry of Nitrogen Dioxide

M. Kirsch / H.-G. Korth / R. Sustmann / H. de Groot
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/BC.2002.043

Abstract

Nitrogen dioxide (NO2) is an oxidizing free radical which can initiate a variety of destructive pathways in living systems, and several diseases are suspected to be connected with both exogenously and endogenously formed NO2. Peroxynitrite (ONOO/ONOOH) is believed to be an important endogenous source of NO2 radicals, but other sources, among them enzymatically ones, have been identified recently. It also became clear during the last few years that in vivo formation of 3-nitrotyrosine strictly depends on the availability of NO2 radicals. Since nitrogen dioxide is a very toxic compound an arsenal of antioxidants (e.g. vitamin C, glutathione, vitamin E, and βcarotene) must eliminate this harmful radical in vivo. Here the recently identified superoxide (O2)dependent formation of peroxynitrate (O2NOO) and the central role of vitamin C are of special importance.

About the article

Published Online: 2005-06-01

Published in Print: 2002-04-12


Citation Information: Biological Chemistry, Volume 383, Issue 3-4, Pages 389–399, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2002.043.

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