Jump to ContentJump to Main Navigation
Show Summary Details
In This Section

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

12 Issues per year

IMPACT FACTOR 2016: 3.273

CiteScore 2016: 3.01

SCImago Journal Rank (SJR) 2016: 1.679
Source Normalized Impact per Paper (SNIP) 2016: 0.800

See all formats and pricing
In This Section
Volume 383, Issue 3-4 (Apr 2002)


Nitric Oxide and Peroxynitrite Interactions with Mitochondria

R. Radi / A. Cassina / R. Hodara
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/BC.2002.044


Nitric oxide (NO) and peroxynitrite (ONOO) avidly interact with mitochondrial components, leading to a range of biological responses spanning from the modulation of mitochondrial respiration, mitochondrial dysfunction to the signaling of apoptotic cell death. Physiological levels of NO primarily interact with cytochrome c oxidase, leading to a competitive and reversible inhibition of mitochondrial oxygen uptake. In turn, this leads to alterations in electrochemical gradients, which affect calcium uptake and may regulate processes such as mitochondrial transition pore (MTP) opening and the release of proapoptotic proteins. Large or persistent levels of NO in mitochondria promote mitochondrial oxidant formation. Peroxynitrite formed either extra or intramitochondrially leads to oxidative damage, most notably at complexes I and II of the electron transport chain, ATPase, aconitase and Mnsuperoxide dismutase. Mitochondrial scavenging systems for peroxynitrite and peroxynitritederived radicals such as carbonate (CO3.) and nitrogen dioxide radicals (NO2) include cytochrome c oxidase, glutathione and ubiquinol and serve to partially attenuate the reactions of these oxidants with critical mitochondrial targets. Detection of nitrated mitochondrial proteins in vivo supports the concept that mitochondria constitute central loci of the toxic effects of excess reactive nitrogen species. In this review we will provide an overview of the biochemical mechanisms by which NO and ONOO regulate or alter mitochondrial functions.

About the article

Published Online: 2005-06-01

Published in Print: 2002-04-12

Citation Information: Biological Chemistry, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2002.044.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Sameer N. Goyal, Reddy M. Navya, Kalpesh R. Patil, Kartik T. Nakhate, Shreesh Ojha, Chandragouda R. Patil, and Yogeeta O. Agrawal
Chemico-Biological Interactions, 2015
Alessandro Lana and Lello Zolla
Trends in Food Science & Technology, 2015
Dorival Martins, Iolie Bakas, Kelly McIntosh, and Ann M. English
Free Radical Biology and Medicine, 2015, Volume 85, Page 138
Ji-Hong Moon and Sang-Youel Park
International Journal of Molecular Medicine, 2014
Jian-Yong Zhu, Bao Cheng, Yin-Jia Zheng, Zhen Dong, Shu-Ling Lin, Gui-Hua Tang, Qiong Gu, and Sheng Yin
RSC Adv., 2015, Volume 5, Number 16, Page 12202
Badar ul Islam, Safia Habib, Parvez Ahmad, Shaziya Allarakha, Moinuddin, and Asif Ali
Indian Journal of Clinical Biochemistry, 2015
Lauren M Slosky and Todd W Vanderah
Expert Opinion on Therapeutic Patents, 2015, Volume 25, Number 4, Page 443
Zhoumou Chen, Carolina Muscoli, Tim Doyle, L. Bryant, Salvatore Cuzzocrea, Vincenzo Mollace, Rosanna Mastroianni, Emanuela Masini, and Daniela Salvemini
Pain, 2010, Volume 149, Number 1, Page 100
P. Uribe, R. Boguen, F. Treulen, R. Sanchez, and J. V. Villegas
Molecular Human Reproduction, 2015, Volume 21, Number 3, Page 237
Lucas Frungillo, Michael J. Skelly, Gary J. Loake, Steven H. Spoel, and Ione Salgado
Nature Communications, 2014, Volume 5, Page 5401
Zhen Dong, Qiong Gu, Bao Cheng, Zhong-Bin Cheng, Gui-Hua Tang, Zhang-Hua Sun, Jun-Sheng Zhang, Jing-Mei Bao, and Sheng Yin
RSC Adv., 2014, Volume 4, Number 98, Page 55036
Dan Luo, Terry C. T. Or, Cindy L. H. Yang, and Allan S. Y. Lau
ACS Chemical Neuroscience, 2014, Volume 5, Number 9, Page 855
Mohamed A. Abdelmegeed and Byoung-Joon Song
Oxidative Medicine and Cellular Longevity, 2014, Volume 2014, Page 1
Andreas Daiber, Steffen Daub, Markus Bachschmid, Stefan Schildknecht, Matthias Oelze, Sebastian Steven, Patrick Schmidt, Alexandra Megner, Masayuki Wada, Tadashi Tanabe, Thomas Münzel, Serge Bottari, and Volker Ullrich
International Journal of Molecular Sciences, 2013, Volume 14, Number 4, Page 7542
Ernesto Miquel, Adriana Cassina, Laura Martínez-Palma, José M. Souza, Carmen Bolatto, Sebastián Rodríguez-Bottero, Angela Logan, Robin A.J. Smith, Michael P. Murphy, Luis Barbeito, Rafael Radi, and Patricia Cassina
Free Radical Biology and Medicine, 2014, Volume 70, Page 204
Fangfang Liu, Jürgen Pauluhn, Hubert Trübel, and Chen Wang
Toxicology, 2014, Volume 315, Page 17
Yongke Lu, Stephen C. Ward, and Natalia Nieto
Alcoholism: Clinical and Experimental Research, 2014, Volume 38, Number 3, Page 649
Ione Salgado, M. Carmen Martínez, Halley Caixeta Oliveira, and Lucas Frungillo
Brazilian Journal of Botany, 2013, Volume 36, Number 2, Page 89
Gerald S. Supinski and Leigh A. Callahan
American Journal of Respiratory and Critical Care Medicine, 2006, Volume 173, Number 11, Page 1240
Humberto Rodriguez-Rocha, Aracely Garcia-Garcia, Chillian Pickett, Sumin Li, Jocelyn Jones, Han Chen, Brian Webb, Jae Choi, You Zhou, Matthew C. Zimmerman, and Rodrigo Franco
Free Radical Biology and Medicine, 2013, Volume 61, Page 370
Lucas Frungillo, Jusceley Fatima Palamim de Oliveira, Elzira Elisabeth Saviani, Halley Caixeta Oliveira, M. Carmen Martínez, and Ione Salgado
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2013, Volume 1827, Number 3, Page 239
Suk-Yee Li, Zhong Jie Fu, and Amy C. Y. Lo
Oxidative Medicine and Cellular Longevity, 2012, Volume 2012, Page 1
Andrej Musatov and Neal C. Robinson
Free Radical Research, 2012, Volume 46, Number 11, Page 1313
María C. Martí, Igor Florez-Sarasa, Daymi Camejo, Beatriz Pallol, Ana Ortiz, Miquel Ribas-Carbó, Ana Jiménez, and Francisca Sevilla
Physiologia Plantarum, 2013, Volume 147, Number 2, Page 194
Daniela Salvemini
Archives of Biochemistry and Biophysics, 2009, Volume 484, Number 2, Page 238
A. Latini, M. Rodriguez, R. Borba Rosa, K. Scussiato, G. Leipnitz, D. Reis de Assis, G. da Costa Ferreira, C. Funchal, M.C. Jacques-Silva, L. Buzin, R. Giugliani, A. Cassina, R. Radi, and M. Wajner
Neuroscience, 2005, Volume 135, Number 1, Page 111
Łukasz Szewczyk, Justyna Ulańska, Marta Dubiel, Anna Maria Osyczka, and Grzegorz Tylko
Toxicology in Vitro, 2012, Volume 26, Number 6, Page 897
Tung Ming Leung, Yongke Lu, Wei Yan, José A. Morón-Concepción, Stephen C. Ward, Xiaodong Ge, Laura Conde de la Rosa, and Natalia Nieto
Hepatology, 2012, Volume 55, Number 5, Page 1596
T. Regueira, M. Andresen, and S. Djafarzadeh
Medicina Intensiva, 2009, Volume 33, Number 8, Page 385
I. A. Nikitina, M. N. Starodubtseva, and A. I. Grishchuk
Advances in Gerontology, 2012, Volume 2, Number 1, Page 45
T. Regueira, M. Andresen, M. Mercado, and P. Downey
Medicina Intensiva (English Edition), 2011, Volume 35, Number 7, Page 424
Saverio Marchi, Carlotta Giorgi, Jan M. Suski, Chiara Agnoletto, Angela Bononi, Massimo Bonora, Elena De Marchi, Sonia Missiroli, Simone Patergnani, Federica Poletti, Alessandro Rimessi, Jerzy Duszynski, Mariusz R. Wieckowski, and Paolo Pinton
Journal of Signal Transduction, 2012, Volume 2012, Page 1
Patrícia Fernanda Schuck, Anelise Tonin, Gustavo da Costa Ferreira, Rafael Borba Rosa, Alexandra Latini, Fabrício Balestro, Marcos Luiz Santos Perry, Clóvis Milton Duval Wannmacher, Angela Terezinha de Souza Wyse, and Moacir Wajner
Neuroscience Research, 2007, Volume 57, Number 2, Page 277
T. Doyle, L. Bryant, I. Batinic-Haberle, J. Little, S. Cuzzocrea, E. Masini, I. Spasojevic, and D. Salvemini
Neuroscience, 2009, Volume 164, Number 2, Page 702
Nikunj K. Chokshi, Yigit S. Guner, Catherine J. Hunter, Jeffrey S. Upperman, Anatoly Grishin, and Henri R. Ford
Seminars in Perinatology, 2008, Volume 32, Number 2, Page 92
Jennifer E. Embury, Catherine E. Charron, Anatoly Martynyuk, Andreas G. Zori, Bin Liu, Syed F. Ali, Neil E. Rowland, and Philip J. Laipis
Brain Research, 2007, Volume 1127, Page 136
Sanjoy Roychowdhury, Gerald Wolf, Gerburg Keilhoff, and Thomas F.W Horn
Nitric Oxide, 2003, Volume 8, Number 1, Page 39
Amy Bishop, Shaw-Fang Yet, Mu-En Lee, Mark A. Perrella, and Bruce Demple
Biochemical and Biophysical Research Communications, 2004, Volume 325, Number 1, Page 3
T. Regueira, M. Andresen, M. Mercado, and P. Downey
Medicina Intensiva, 2011, Volume 35, Number 7, Page 424
A. Ramachandran, E. Ceaser, and V. M. Darley-Usmar
Proceedings of the National Academy of Sciences, 2004, Volume 101, Number 1, Page 384
Daniela Salvemini, Joshua W. Little, Timothy Doyle, and William L. Neumann
Free Radical Biology and Medicine, 2011, Volume 51, Number 5, Page 951
D. Steinritz, A. Elischer, F. Balszuweit, S. Gonder, A. Heinrich, W. Bloch, H. Thiermann, and K. Kehe
Toxicology Letters, 2009, Volume 188, Number 3, Page 263
Govind T. Vatassery, Karen S. SantaCruz, Eugene G. DeMaster, Hung T. Quach, and W. Ed Smith
Neurochemistry International, 2004, Volume 45, Number 7, Page 963
Nina J Solenski, Vannessa K Kostecki, Serena Dovey, and Ammasi Periasamy
Molecular and Cellular Neuroscience, 2003, Volume 24, Number 4, Page 1151
Beatrycze Nowicka and Jerzy Kruk
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2010, Volume 1797, Number 9, Page 1587
Yiqin Xiong and Edward D. Hall
Experimental Neurology, 2009, Volume 216, Number 1, Page 105
M.L. Getchell, D.S. Shah, S.K. Buch, D.G. Davis, and T.V. Getchell
Neurobiology of Aging, 2003, Volume 24, Number 5, Page 663
H. Fai Poon, Holly M. Shepherd, Tanea T. Reed, Vittorio Calabrese, Anna-Maria Giuffrida Stella, Giovanni Pennisi, Jian Cai, William M. Pierce, Jon B. Klein, and D. Allan Butterfield
Neurobiology of Aging, 2006, Volume 27, Number 7, Page 1020
Alicia J. Kowaltowski, Nadja C. de Souza-Pinto, Roger F. Castilho, and Anibal E. Vercesi
Free Radical Biology and Medicine, 2009, Volume 47, Number 4, Page 333
Subhasis Das, N. Gautam, Sankar Kumar Dey, Tarasankar Maiti, and Somenath Roy
Applied Physiology, Nutrition, and Metabolism, 2009, Volume 34, Number 2, Page 124
Daniela Salvemini and William L. Neumann
Trends in Pharmacological Sciences, 2009, Volume 30, Number 4, Page 194
Kimberly M Carrico, Radhika A Vaishnav, and Edward D Hall
Journal of Neurotrauma, 2009, Page 110306202455053
Renu A. Kowluru
Antioxidants & Redox Signaling, 2005, Volume 7, Number 11-12, Page 1581
Ekambaram Padmini, Srinivasan Lavanya, and Venkatraman Uthra
Clinical Chemistry and Laboratory Medicine, 2009, Volume 47, Number 9
Paolo Ascenzi, Alessandra di Masi, Clara Sciorati, and Emilio Clementi
BioFactors, 2010, Volume 36, Number 4, Page 264
H. Fai Poon, Radhika A. Vaishnav, D. Allan Butterfield, Marilyn L. Getchell, and Thomas V. Getchell
Journal of Neurochemistry, 2005, Volume 94, Number 2, Page 380
Dou Yu, William L. Neeley, Christopher D. Pritchard, Jonathan R. Slotkin, Eric J. Woodard, Robert Langer, and Yang D. Teng
Stem Cells, 2009, Volume 27, Number 5, Page 1212
Leticia Martínez-Caro, José A. Lorente, Judith Marín-Corral, Carolina Sánchez-Rodríguez, Alberto Sánchez-Ferrer, Nicolás Nin, Antonio Ferruelo, Marta de Paula, Pilar Fernández-Segoviano, Esther Barreiro, and Andrés Esteban
Intensive Care Medicine, 2009, Volume 35, Number 6, Page 1110
Sabine Borgmann
Analytical and Bioanalytical Chemistry, 2009, Volume 394, Number 1, Page 95
Inmaculada García-Ruiz, Cristina Rodríguez-Juan, Teresa Díaz-Sanjuan, Pilar del Hoyo, Francisco Colina, Teresa Muñoz-Yagüe, and José A. Solís-Herruzo
Hepatology, 2006, Volume 44, Number 3, Page 581
Baskaran Thyagarajan, Roland Malli, Kurt Schmidt, Wolfgang F Graier, and Klaus Groschner
British Journal of Pharmacology, 2002, Volume 137, Number 6, Page 821
Sally A. Madsen-Bouterse and Renu A. Kowluru
Reviews in Endocrine and Metabolic Disorders, 2008, Volume 9, Number 4, Page 315
Emilie Chanseaume, Christophe Giraudet, Céline Gryson, Stéphane Walrand, Paulette Rousset, Yves Boirie, and Béatrice Morio
Obesity, 2007, Volume 15, Number 4, Page 853
Igor G. L. Libourel, Paul C. Bethke, Roberto De Michele, and Russell L. Jones
Planta, 2006, Volume 223, Number 4, Page 813
Jing-Hsien Chen, Fen-Pi Chou, Hui-Hsuan Lin, and Chau-Jong Wang
Archives of Toxicology, 2005, Volume 79, Number 12, Page 694
Inmaculada García-Ruiz, Cristina Rodríguez-Juan, Teresa Díaz-Sanjuán, Miguel Ángel Martínez, Teresa Muñoz-Yagüe, and José A. Solís-Herruzo
Hepatology, 2007, Volume 46, Number 2, Page 414
J. Briede, M. Stivrina, Dz. Stoldere, B. Vigante, and G. Duburs
Cell Biochemistry and Function, 2007, Volume 25, Number 6, Page 673
T. A. Mejía-García and R. Paes-de-Carvalho
Journal of Neurochemistry, 2007, Volume 100, Number 2, Page 382
T. E. Shumilova, A. D. Nozdrachev, G. B. Vainshtein, V. N. Semernya, V. I. Shereshkov, I. N. Yanvareva, and A. A. Panov
Journal of Evolutionary Biochemistry and Physiology, 2006, Volume 42, Number 1, Page 77
Jazmin M. Pérez-Rojas and Pablo Muriel
Journal of Applied Toxicology, 2005, Volume 25, Number 6, Page 522
Trinity J. Bivalacqua, Mustafa F. Usta, Muammer Kendirci, Leena Pradhan, Xavier Alvarez, Hunter C. Champion, Philip J. Kadowitz, and Wayne J.G. Hellstrom
The Journal of Sexual Medicine, 2005, Volume 2, Number 2, Page 187
De-xin LI, Si-ling WANG, Yoshimasa ITO, Jing-hai ZHANG, and Chun-fu WU
Acta Pharmacologica Sinica, 2005, Volume 26, Number 3, Page 359
Nicol�s Nin, Adriana Cassina, Jos� Boggia, Evangelina Alfonso, Horacio Botti, Gonzalo Peluffo, Andr�s Trostchansky, Carlos Batthy�ny, Rafael Radi, Homero Rubbo, and F. Javier Hurtado
Intensive Care Medicine, 2004, Volume 30, Number 12, Page 2271
Julio F. Turrens
The Journal of Physiology, 2003, Volume 552, Number 2, Page 335
Aparna Venkatraman, Sruti Shiva, Amanda Wigley, Elena Ulasova, David Chhieng, Shannon M. Bailey, and Victor M. Darley-Usmar
Hepatology, 2004, Volume 40, Number 3, Page 565
Govind T. Vatassery, James C.K. Lai, Eugene G. DeMaster, W. Ed Smith, and Hung T. Quach
Journal of Neuroscience Research, 2004, Volume 75, Number 6, Page 845

Comments (0)

Please log in or register to comment.
Log in