Jump to ContentJump to Main Navigation
Show Summary Details

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred

12 Issues per year

IMPACT FACTOR 2015: 2.710
Rank 142 out of 289 in category Biochemistry & Molecular Biology in the 2015 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2015: 1.607
Source Normalized Impact per Paper (SNIP) 2015: 0.751
Impact per Publication (IPP) 2015: 2.609

See all formats and pricing
Just Accepted


Nitric Oxide and Cell Signaling Pathways in Mitochondrial-Dependent Apoptosis

C.S. Boyd / E. Cadenas
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/BC.2002.045


Nitric oxide, generated by endogenous nitric oxide synthases or nitric oxide donors, can promote or prevent apoptosis induced by diverse proapoptotic stimuli in cell culture models. Both mitochondrialdependent and independent apoptotic signaling pathways mediate this dichotomous cellular response to nitric oxide. The molecular mechanisms behind these effects are complex and involve a number of nitrogen oxiderelated species that are more reactive than nitric oxide itself. The local cellular environment plays a dynamic role in determining the nature and concentration of these species. Important components of the microenvironment include: the cellular redox state, glutathione, transition metals and the presence of other oxygen and nitrogencentered radicals. In particular, redoxsensitive nitrosating species are favorably generated under physiological conditions and capable of modifying multiple cell signaling pathways through reversible Snitrosation reactions. Cytochrome c release from mitochondria is an important mechanism for the activation of caspase-3 and the initiation of cell death in response to intrinsic proapoptotic stimuli, including oxidative and nitrosative stress. In turn, caspases and mitogen associated protein kinases may modulate cytochrome c release through their effects on the Bcl-2 family of proteins. This review will focus on (i) the importance of the cellular environment in determining the fate of nitric oxide and (ii) the ability of Snitrosation to regulate mitochondrialdependent apoptosis at the level of mitochondrial bioenergetics, cytochrome c release, caspases, mitogen associated protein kinases, and the Bcl-2 family of proteins.

About the article

Published Online: 2005-06-01

Published in Print: 2002-04-12

Citation Information: Biological Chemistry, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2002.045. Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Panagiotis Lepetsos and Athanasios G. Papavassiliou
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2016, Volume 1862, Number 4, Page 576
L. Tao, E. Gao, N. S. Bryan, Y. Qu, H.-R. Liu, A. Hu, T. A. Christopher, B. L. Lopez, J. Yodoi, W. J. Koch, M. Feelisch, and X. L. Ma
Proceedings of the National Academy of Sciences, 2004, Volume 101, Number 31, Page 11471
Bogdan Calenic, Kazuhiko Okamura, Ken Yaegaki, Serban Tovaru, Tomoko Tanaka, and Toshio Imai
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 2014, Volume 26, Number 2, Page 221
Emanuele Marzetti, Riccardo Calvani, Matteo Cesari, Thomas W. Buford, Maria Lorenzi, Bradley J. Behnke, and Christiaan Leeuwenburgh
The International Journal of Biochemistry & Cell Biology, 2013, Volume 45, Number 10, Page 2288
Alexis D. Ostrowski, Brian F. Lin, Matthew V. Tirrell, and Peter C. Ford
Molecular Pharmaceutics, 2012, Volume 9, Number 10, Page 2950
Yuan Gao, Li Li, Jianjun Zhang, Feng Su, Zhenhua Gong, Yisheng Lai, and Yihua Zhang
Archives of Pharmacal Research, 2012, Volume 35, Number 7, Page 1177
Fei Yin, Alberto Boveris, and Enrique Cadenas
Antioxidants & Redox Signaling, 2014, Volume 20, Number 2, Page 353
He-Ping Chen, Ming He, Zhu-Jun Mei, Qi-Ren Huang, and Min Huang
Canadian Journal of Physiology and Pharmacology, 2012, Volume 90, Number 7, Page 873
M.T Viscomi, F Florenzano, D Conversi, G Bernardi, and M Molinari
Neuroscience, 2004, Volume 123, Number 2, Page 393
Stefania Comes, Annamaria Locascio, Francesco Silvestre, Marco d'Ischia, Gian Luigi Russo, Elisabetta Tosti, Margherita Branno, and Anna Palumbo
Developmental Biology, 2007, Volume 306, Number 2, Page 772
P. Aguilar-Melero, G. Ferrín, and J. Muntané
Journal of Proteomics, 2012, Volume 75, Number 3, Page 740
Lei Lv, Shi-Sen Jiang, Jun Xu, Jian-Bin Gong, and Yan Cheng
Clinical and Experimental Pharmacology and Physiology, 2012, Volume 39, Number 1, Page 20
Elvira Brunelli, Ida Perrotta, Erminia Talarico, and Sandro Tripepi
Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 2005, Volume 142, Number 2, Page 249
Michael J. Rose, Marilyn M. Olmstead, and Pradip K. Mascharak
Polyhedron, 2007, Volume 26, Number 16, Page 4713
Xiaozhong Hu, Decong Hu, and Ying Xu
Environmental Toxicology and Pharmacology, 2009, Volume 27, Number 3, Page 327
Agnieszka Janczyk, Agnieszka Wolnicka-Glubisz, Antonina Chmura, Martyna Elas, Zenon Matuszak, Grazyna Stochel, and Krystyna Urbanska
Nitric Oxide, 2004, Volume 10, Number 1, Page 42
Takuya Numata, Takeshi Saito, Kazuyo Maekawa, Yasumitsu Takahashi, Hiroshi Saitoh, Toshiyuki Hosokawa, Hiroyoshi Fujita, and Masaaki Kurasaki
Biochemical and Biophysical Research Communications, 2002, Volume 297, Number 3, Page 517
Fumiya Hongo, Hermes Garban, Sara Huerta-Yepez, Mario Vega, Ali R. Jazirehi, Yoichi Mizutani, Tsuneharu Miki, and Benjamin Bonavida
Biochemical and Biophysical Research Communications, 2005, Volume 336, Number 2, Page 692
Amy Bishop, Shaw-Fang Yet, Mu-En Lee, Mark A. Perrella, and Bruce Demple
Biochemical and Biophysical Research Communications, 2004, Volume 325, Number 1, Page 3
Frank Petrat, Tongju Li, Nathalie Dehne, Herbert de Groot, and Ursula Rauen
Life Sciences, 2006, Volume 79, Number 17, Page 1606
Laura B. Valdez, Tamara Zaobornyj, Silvia Alvarez, Juanita Bustamante, Lidia E. Costa, and Alberto Boveris
Molecular Aspects of Medicine, 2004, Volume 25, Number 1-2, Page 49
Jim C. Oates and Gary S. Gilkeson
Clinical Immunology, 2006, Volume 121, Number 3, Page 243
Robin J. Goody, Cristen C. Hoyt, and Kenneth L. Tyler
Experimental Neurology, 2005, Volume 195, Number 2, Page 379
Han-Ming Shen and Zheng-gang Liu
Free Radical Biology and Medicine, 2006, Volume 40, Number 6, Page 928
Michael J. Rose and Pradip K. Mascharak
Coordination Chemistry Reviews, 2008, Volume 252, Number 18-20, Page 2093
Aura A Eroy-Reveles and Pradip K Mascharak
Future Medicinal Chemistry, 2009, Volume 1, Number 8, Page 1497
Eric Solary, Ali Bettaieb, Laurence Dubrez-Daloz, and Laurent Corcos
Leukemia & Lymphoma, 2003, Volume 44, Number 4, Page 563
Narasimham L. Parinandi, Ashish Sharma, Timothy D. Eubank, Bruce F. Kaufman, Vijay Kumar Kutala, Clay B. Marsh, Louis J. Ignarro, and Periannan Kuppusamy
Antioxidants & Redox Signaling, 2007, Volume 9, Number 11, Page 1837
Jim C. Oates
Autoimmunity, 2010, Volume 43, Number 1, Page 56
L. A. Ridnour, D. D. Thomas, D. Mancardi, M. G. Espey, K. M. Miranda, N. Paolocci, M. Feelisch, J. Fukuto, and D. A. Wink
Biological Chemistry, 2004, Volume 385, Number 1, Page 1
Yang Wu, Zhong-yuan Xia, Qing-tao Meng, Jie Zhu, Shaoqing Lei, Jinjin Xu, and Juan Dou
Journal of Biomedicine and Biotechnology, 2011, Volume 2011, Page 1
Jue Tian, Zi Yan, Ye Wu, Su-li Zhang, Ke Wang, Xiu-rui Ma, Li Guo, Jin Wang, Lin Zuo, Jing-yi Liu, Lin Quan, and Hui-rong Liu
Acta Pharmacologica Sinica, 2010, Volume 31, Number 10, Page 1324
J. Pourova, M. Kottova, M. Voprsalova, and M. Pour
Acta Physiologica, 2010, Volume 198, Number 1, Page 15
Rocío Pérez-Rodríguez, Cesáreo Roncero, Ana María Oliván, María Pilar González, and María Jesús Oset-Gasque
Journal of Neurochemistry, 2009, Volume 108, Number 4, Page 1083
T. Hagemann, T. Lawrence, I. McNeish, K. A. Charles, H. Kulbe, R. G. Thompson, S. C. Robinson, and F. R. Balkwill
Journal of Experimental Medicine, 2008, Volume 205, Number 6, Page 1261
T Bill Cai and Peng George Wang
Expert Opinion on Therapeutic Patents, 2004, Volume 14, Number 6, Page 849
Jim C. Oates, Stephanie R. Shaftman, Sally E. Self, and Gary S. Gilkeson
Arthritis & Rheumatism, 2008, Volume 58, Number 1, Page 263
James C. Oates, Libby W. Farrelly, Ann F. Hofbauer, Wei Wang, and Gary S. Gilkeson
Arthritis & Rheumatism, 2007, Volume 56, Number 11, Page 3738
Aura A. Eroy-Reveles, C. Gianna Hoffman-Luca, and Pradip K. Mascharak
Dalton Transactions, 2007, Number 45, Page 5268
Carolyn Jack, Jack Antel, Wolfgang Brück, and Tanja Kuhlmann
Glia, 2007, Volume 55, Number 9, Page 926
G. Sorarù, L. Vergani, L. Fedrizzi, C. D?Ascenzo, A. Polo, B. Bernazzi, and C. Angelini
Neuropathology and Applied Neurobiology, 2007, Volume 33, Number 2, Page 204
Yinghui Huang, Casey Lee, Per Borgström, and Ruth A Gjerset
Molecular Therapy, 2007, Volume 15, Number 3, Page 524
Istvan Szundi, Michael J. Rose, Indranil Sen, Aura A. Eroy-Reveles, Pradip K. Mascharak, and Ólöf Einarsdóttir
Photochemistry and Photobiology, 2006, Volume 82, Number 5, Page 1377
Stanley Muravchick and Richard J. Levy
Anesthesiology, 2006, Volume 105, Number 4, Page 819
D.-Y. Li, L. Tao, H. Liu, T. A. Christopher, B. L. Lopez, and X. L. Ma
Apoptosis, 2006, Volume 11, Number 6, Page 923
Zheng-Guo Cui, Takashi Kondo, and Hideki Matsumoto
Journal of Cellular Physiology, 2006, Volume 206, Number 2, Page 468
Zhao Zhong Chong, Jing-Qiong Kang, and Kenneth Maiese
Journal of Cerebral Blood Flow & Metabolism, 2003, Page 320
Cory D. Bishop and Bruce P. Brandhorst
Evolution and Development, 2003, Volume 5, Number 5, Page 542
Juergen Frank, Christine Lambert, Hans Konrad Biesalski, Oliver Thews, Peter Vaupel, and Debra K. Kelleher
International Journal of Cancer, 2003, Volume 107, Number 6, Page 941

Comments (0)

Please log in or register to comment.
Log in