Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

12 Issues per year

IMPACT FACTOR 2016: 3.273

CiteScore 2016: 3.01

SCImago Journal Rank (SJR) 2016: 1.679
Source Normalized Impact per Paper (SNIP) 2016: 0.800

See all formats and pricing
More options …
Volume 383, Issue 3-4 (Apr 2002)


The Chelatable Iron Pool in Living Cells: A Methodically Defined Quantity

F. Petrat / H. de Groot / R. Sustmann / U. Rauen
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/BC.2002.051


A very small, predominantly cytosolic pool of iron ions plays the central role in the cellular iron metabolism. It links the cellular iron uptake with the insertion of the metal in iron storage proteins and other essential ironcontaining molecules. Furthermore, this transit (labile) pool is essentially involved in the pathogenesis of a number of diseases. Due to its high physiological and pathophysiological significance, numerous methods for its characterization have been developed during the last five decades. Most of these methods, however, influence the size and nature of the transit iron pool artificially, as they are not applicable to viable biological material. Recently, fluorescence spectroscopic methods for measurements within viable cells have become available. Although these methods avoid the artifacts of previous methods, studies using fluorescent iron indicators revealed that the intracellular transit iron pool, which is methodically assessed as chelatable iron, is substantially defined by the method and/or the ironchelating indicator applied for its detection, since the iron ions are bound to a large number of different ligands in different metabolic compartments. A more comprehensive characterization of the nature and the role of the thus not uniform cellular transit iron pool therefore requires parallel employment of different indicator molecules, which clearly differ in their intracellular distribution and their physicochemical characteristics.

About the article

Published Online: 2005-06-01

Published in Print: 2002-04-12

Citation Information: Biological Chemistry, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2002.051.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Zhiyong Deng, David H. Manz, Suzy Torti, and Frank M. Torti
Antioxidants & Redox Signaling, 2017
Pierre-Alain Clavien and Philipp Dutkowski
Liver Transplantation, 2017, Volume 23, Number S1, Page S52
Jason R. Hickok, Sumit Sahni, Yuliya Mikhed, Marcelo G. Bonini, and Douglas D. Thomas
Journal of Biological Chemistry, 2011, Volume 286, Number 48, Page 41413
Maria Adelaida Gomez, Laleh Alisaraie, Marina Tiemi Shio, Albert M. Berghuis, Colette Lebrun, Isabelle Gautier-Luneau, and Martin Olivier
Journal of Biological Chemistry, 2010, Volume 285, Number 32, Page 24620
Muralidhar L. Hegde, Pavana M. Hegde, Luis M. F. Holthauzen, Tapas K. Hazra, K. S. Jagannatha Rao, and Sankar Mitra
Journal of Biological Chemistry, 2010, Volume 285, Number 37, Page 28812
Jeffrey A. Gralnick and Diana M. Downs
Journal of Biological Chemistry, 2003, Volume 278, Number 23, Page 20708
Oyebode Olakanmi, Larry S. Schlesinger, Ambar Ahmed, and Bradley E. Britigan
Journal of Biological Chemistry, 2002, Volume 277, Number 51, Page 49727
Utta Berchner-Pfannschmidt, Frank Petrat, Kathrin Doege, Buena Trinidad, Patricia Freitag, Eric Metzen, Herbert de Groot, and Joachim Fandrey
Journal of Biological Chemistry, 2004, Volume 279, Number 43, Page 44976
Brigitte Sturm, Ute Bistrich, Matthias Schranzhofer, Joseph P. Sarsero, Ursula Rauen, Barbara Scheiber-Mojdehkar, Herbert de Groot, Panos Ioannou, and Frank Petrat
Journal of Biological Chemistry, 2005, Volume 280, Number 8, Page 6701
José C. Toledo, Charles A. Bosworth, Seth W. Hennon, Harry A. Mahtani, Hector A. Bergonia, and Jack R. Lancaster
Journal of Biological Chemistry, 2008, Volume 283, Number 43, Page 28926
Yue-Ting Wang and Douglas D. Thomas
Current Pharmacology Reports, 2017, Volume 3, Number 4, Page 151
Benjamin Spangler, Charles W Morgan, Shaun D Fontaine, Mark N Vander Wal, Christopher J Chang, James A Wells, and Adam R Renslo
Nature Chemical Biology, 2016, Volume 12, Number 9, Page 680
M.D. Mantzaris, S. Bellou, V. Skiada, N. Kitsati, T. Fotsis, and D. Galaris
Free Radical Biology and Medicine, 2016, Volume 97, Page 454
Erik Bründermann, Andreas Bergner, Frank Petrat, Robert Schiwon, Götz Wollny, Ilona Kopf, Herbert de Groot, and Martina Havenith
The Analyst, 2004, Volume 129, Number 10, Page 893
Paschalis-Thomas Doulias, Lambros Nousis, Ben-Zhan Zhu, Balz Frei, and Dimitrios Galaris
Free Radical Research, 2005, Volume 39, Number 2, Page 125
Aneta Balcerczyk, Marcin Kruszewski, and Grzegorz Bartosz
Free Radical Research, 2007, Volume 41, Number 5, Page 563
Nikolaus Bresgen and Peter Eckl
Biomolecules, 2015, Volume 5, Number 2, Page 808
Frank Thévenod and Natascha A. Wolff
Metallomics, 2016, Volume 8, Number 1, Page 17
Victor G. Mihucz, Florian Meirer, Zsófia Polgári, Andrea Réti, Giancarlo Pepponi, Dieter Ingerle, Norbert Szoboszlai, and Christina Streli
JBIC Journal of Biological Inorganic Chemistry, 2016, Volume 21, Number 2, Page 241
Miguel Arredondo and Marco T. Núñez
Molecular Aspects of Medicine, 2005, Volume 26, Number 4-5, Page 313
Nicolás Veiga, Israel Macho, Kerman Gómez, Gabriel González, Carlos Kremer, and Julia Torres
Journal of Molecular Structure, 2015, Volume 1098, Page 55
Sean P. McCormick, Michael J. Moore, and Paul A. Lindahl
Biochemistry, 2015, Volume 54, Number 22, Page 3442
Emmanuel Pourcelot, Marine Lénon, Nicolas Mobilia, Jean-Yves Cahn, Josiane Arnaud, Eric Fanchon, Jean-Marc Moulis, and Pascal Mossuz
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2015, Volume 1853, Number 7, Page 1596
Kanjana Pangjit, Ratana Banjerdpongchai, Chada Phisalaphong, Suthat Fucharoen, and Somdet Srichairatanakool
Advances in Bioscience and Biotechnology, 2012, Volume 03, Number 07, Page 1060
Herbert A. Wetli, Peter D. Buckett, and Marianne Wessling-Resnick
Chemistry & Biology, 2006, Volume 13, Number 9, Page 965
Gábor Veres, Tamás Radovits, Béla Merkely, Matthias Karck, and Gábor Szabó
Journal of Cardiothoracic Surgery, 2015, Volume 10, Number 1
Scott J Dixon and Brent R Stockwell
Nature Chemical Biology, 2013, Volume 10, Number 1, Page 9
Yongmin Ma, Xiaole Kong, Vincenzo Abbate, and Robert C. Hider
Sensors and Actuators B: Chemical, 2015, Volume 213, Page 12
Yongmin Ma, V. Abbate, and R. C. Hider
Metallomics, 2015, Volume 7, Number 2, Page 212
Natalia P. Mena, Pamela J. Urrutia, Fernanda Lourido, Carlos M. Carrasco, and Marco T. Núñez
Mitochondrion, 2015, Volume 21, Page 92
Narendra Reddy Chereddy, M. V. Niladri Raju, Peethani Nagaraju, Venkat Raghavan Krishnaswamy, Purna Sai Korrapati, Prakriti Ranjan Bangal, and Vaidya Jayathirtha Rao
The Analyst, 2014, Volume 139, Number 24, Page 6352
Sagi Tamir, Mark L. Paddock, Merav Darash-Yahana-Baram, Sarah H. Holt, Yang Sung Sohn, Lily Agranat, Dorit Michaeli, Jason T. Stofleth, Colin H. Lipper, Faruck Morcos, Ioav Z. Cabantchik, Jose' N. Onuchic, Patricia A. Jennings, Ron Mittler, and Rachel Nechushtai
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2015, Volume 1853, Number 6, Page 1294
Justin C. Moser, Malvika Rawal, Brett A. Wagner, Juan Du, Joseph J. Cullen, and Garry R. Buettner
Redox Biology, 2014, Volume 2, Page 22
Wissam H. Ibrahim, Hosam M. Habib, Hina Kamal, Daret K. St. Clair, and Ching K. Chow
Free Radical Biology and Medicine, 2013, Volume 65, Page 143
M. Pucci Molineris, G. Di Venanzio, M.E. Mamprin, and M.G. Mediavilla
Cryobiology, 2013, Volume 67, Number 1, Page 76
Sean P. McCormick, Mrinmoy Chakrabarti, Allison L. Cockrell, Jinkyu Park, Lora S. Lindahl, and Paul A. Lindahl
Metallomics, 2013, Volume 5, Number 3, Page 232
Elizabeth J. New
Dalton Trans., 2013, Volume 42, Number 9, Page 3210
Shaina L. Byrne, Divya Krishnamurthy, and Marianne Wessling-Resnick
Annual Review of Pharmacology and Toxicology, 2013, Volume 53, Number 1, Page 17
Etheresia Pretorius, Natasha Vermeulen, Janette Bester, Boguslaw Lipinski, and Douglas B. Kell
Toxicology Mechanisms and Methods, 2013, Volume 23, Number 5, Page 352
Xiao-Ming Zhu, Jing Yuan, Ken Cham-Fai Leung, Siu-Fung Lee, Kathy W. Y. Sham, Christopher H. K. Cheng, Doris W. T. Au, Gao-Jun Teng, Anil T. Ahuja, and Yi-Xiang J. Wang
Nanoscale, 2012, Volume 4, Number 18, Page 5744
Natalia Kitsati, Demosthenes Fokas, Maria-Dimitra Ouzouni, Michalis D. Mantzaris, Alexandra Barbouti, and Dimitrios Galaris
Journal of Agricultural and Food Chemistry, 2012, Volume 60, Number 32, Page 7873
Paula Mariela González, Doris Abele, and Susana Puntarulo
Theory in Biosciences, 2012, Volume 131, Number 4, Page 253
Kostas Pantopoulos, Suheel Kumar Porwal, Alan Tartakoff, and L. Devireddy
Biochemistry, 2012, Volume 51, Number 29, Page 5705
Juraj Gáll, Jan Škrha, Richard Buchal, Eva Sedláčková, Karina Verébová, and Jan Pláteník
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2012, Volume 1817, Number 9, Page 1537
Jinfu Zhao, Bryan A. Bertoglio, Michael J. Devinney Jr, Kirk E. Dineley, and Alan R. Kay
Analytical Biochemistry, 2009, Volume 384, Number 1, Page 34
Ursula Rauen, Frank Petrat, Reiner Sustmann, and Herbert de Groot
Journal of Hepatology, 2004, Volume 40, Number 4, Page 607
Rong Zhao, Roy P Planalp, Rong Ma, Bryan T Greene, Bradley T Jones, Martin W Brechbiel, Frank M Torti, and Suzy V Torti
Biochemical Pharmacology, 2004, Volume 67, Number 9, Page 1677
Barney E. Dwyer, Leo R. Zacharski, Dominic J. Balestra, Alan J. Lerner, George Perry, Xiongwei Zhu, and Mark A. Smith
Medical Hypotheses, 2009, Volume 72, Number 5, Page 504
Andrea Galatro, Elizabeth Robello, and Susana Puntarulo
Journal of Integrative Plant Biology, 2012, Volume 54, Number 1, Page 45
Robert C. Hider and Xiao L. Kong
BioMetals, 2011, Volume 24, Number 6, Page 1179
Xiaoling Deng, Ruben Vidal, and Ella W. Englander
Neuroscience Letters, 2010, Volume 479, Number 1, Page 44
John D. Phillips, James P. Kushner, Hector A. Bergonia, and Michael R. Franklin
Blood Cells, Molecules, and Diseases, 2011, Volume 47, Number 4, Page 249
Elizabeth Robello, Andrea Galatro, and Susana Puntarulo
Plant Science, 2007, Volume 172, Number 5, Page 939
Jason R. Hickok, Sumit Sahni, Hong Shen, Akanksha Arvind, Chloe Antoniou, Leslie W.M. Fung, and Douglas D. Thomas
Free Radical Biology and Medicine, 2011, Volume 51, Number 8, Page 1558
Ian M. Møller, Adelina Rogowska-Wrzesinska, and R.S.P. Rao
Journal of Proteomics, 2011, Volume 74, Number 11, Page 2228
Brandon Wayne Alderman, Amy E. Ratliff, and Joseph Ivan Wirgau
Inorganica Chimica Acta, 2009, Volume 362, Number 6, Page 1787
Xi-Ping Huang, Peter J. O’Brien, and Douglas M. Templeton
Chemico-Biological Interactions, 2006, Volume 163, Number 1-2, Page 68
Catherine L. Kwik-Uribe, Stephen Reaney, Zhiwu Zhu, and Donald Smith
Brain Research, 2003, Volume 973, Number 1, Page 1
Aaron P. Landry, Xuewu Duan, Hao Huang, and Huangen Ding
Free Radical Biology and Medicine, 2011, Volume 50, Number 11, Page 1582
J. Christian J. Ray and Denise E. Kirschner
Journal of Theoretical Biology, 2006, Volume 241, Number 2, Page 276
Paula Mariela González and Susana Puntarulo
Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 2011, Volume 153, Number 2, Page 243
Yongmin Ma, Wei Luo, Michel Camplo, Zudong Liu, and Robert C. Hider
Bioorganic & Medicinal Chemistry Letters, 2005, Volume 15, Number 14, Page 3450
A. Ramachandran, E. Ceaser, and V. M. Darley-Usmar
Proceedings of the National Academy of Sciences, 2004, Volume 101, Number 1, Page 384
Elizabeth Robello, Andrea Galatro, and Susana Puntarulo
NeuroToxicology, 2009, Volume 30, Number 3, Page 430
Harriet C. Isom, Emily I. McDevitt, and Mi Sun Moon
Biochimica et Biophysica Acta (BBA) - General Subjects, 2009, Volume 1790, Number 7, Page 650
Julia Torres, Sixto Domínguez, M. Fernanda Cerdá, Gonzalo Obal, Alfredo Mederos, Robin F. Irvine, Alvaro Díaz, and Carlos Kremer
Journal of Inorganic Biochemistry, 2005, Volume 99, Number 3, Page 828
G. Papanikolaou and K. Pantopoulos
Toxicology and Applied Pharmacology, 2005, Volume 202, Number 2, Page 199
Melvin Callapina, Jie Zhou, Steffen Schnitzer, Eric Metzen, Christian Lohr, Joachim W. Deitmer, and Bernhard Brüne
Experimental Cell Research, 2005, Volume 306, Number 1, Page 274
Nicolás Veiga, Julia Torres, Fernanda Cerdá, Gabriel González, Kerman Gómez, David Mansell, Sally Freeman, Sixto Domínguez, and Carlos Kremer
Journal of Molecular Structure, 2011, Volume 994, Number 1-3, Page 343
K. Pamp, U. Kerkweg, H.-G. Korth, F. Homann, U. Rauen, R. Sustmann, H. de Groot, and F. Petrat
Biochimie, 2008, Volume 90, Number 10, Page 1591
William Breuer, Maya Shvartsman, and Z. Ioav Cabantchik
The International Journal of Biochemistry & Cell Biology, 2008, Volume 40, Number 3, Page 350
Ursula Rauen, Tongju Li, Reiner Sustmann, and Herbert de Groot
Free Radical Biology and Medicine, 2004, Volume 37, Number 9, Page 1369
Tiago L. Duarte and George D.D. Jones
Free Radical Biology and Medicine, 2007, Volume 43, Number 8, Page 1165
Or Kakhlon, William Breuer, Arnold Munnich, and Z. Ioav Cabantchik
Canadian Journal of Physiology and Pharmacology, 2010, Volume 88, Number 3, Page 187
Frank Petrat, Sandra Swoboda, Herbert de Groot, and Klaus Juergen Schmitz
Journal of Investigative Surgery, 2010, Volume 23, Number 4, Page 208
Tino Kurz, John W. Eaton, and Ulf T. Brunk
Antioxidants & Redox Signaling, 2010, Volume 13, Number 4, Page 511
Jian Wang and Kostas Pantopoulos
Biochemical Journal, 2011, Volume 434, Number 3, Page 365
U. Rauen and H. de Groot
Biological Chemistry, 2002, Volume 383, Number 3-4
Daniel R. McNeill, Avinash Narayana, Heng-Kuan Wong, and David M. Wilson
Environmental Health Perspectives, 2004, Volume 112, Number 7, Page 799
Qiu Cui, Michael P. Thorgersen, William M. Westler, John L. Markley, and Diana M. Downs
Proteins: Structure, Function, and Bioinformatics, 2005, Volume 62, Number 3, Page 578
Uta Kerkweg, Katja Pamp, Judith Fieker, Frank Petrat, Robert C. Hider, and Herbert de Groot
Shock, 2009, Page 1
Ursula Rauen, Thorsten Kettler-Thiel, Herbert de Groot, Hans-Gert Korth, and Reiner Sustmann
Chemical Biology & Drug Design, 2009, Volume 73, Number 5, Page 494
Lalla Aicha Ba, Mandy Doering, Torsten Burkholz, and Claus Jacob
Metallomics, 2009, Volume 1, Number 4, Page 292
Sarah Fakih, Maria Podinovskaia, Xiaole Kong, Ulrich E. Schaible, Helen L. Collins, and Robert C. Hider
Journal of Pharmaceutical Sciences, 2009, Volume 98, Number 6, Page 2212
Janusz Frackowiak, Anna Potempska, and Bozena Mazur-Kolecka
Acta Neuropathologica, 2009, Volume 117, Number 5, Page 557
A. Campanella, E. Rovelli, P. Santambrogio, A. Cozzi, F. Taroni, and S. Levi
Human Molecular Genetics, 2008, Volume 18, Number 1, Page 1
Nicolás Veiga, Julia Torres, David Mansell, Sally Freeman, Sixto Domínguez, Christopher J. Barker, Alvaro Díaz, and Carlos Kremer
JBIC Journal of Biological Inorganic Chemistry, 2009, Volume 14, Number 1, Page 51
NIPPON SUISAN GAKKAISHI, 2006, Volume 72, Number 5, Page 911
Ursula Rauen, Andrea Springer, Daniela Weisheit, Frank Petrat, Hans-Gert Korth, Herbert de Groot, and Reiner Sustmann
ChemBioChem, 2007, Volume 8, Number 3, Page 341
Willi Sicking, Hans-Gert Korth, Georg Jansen, Herbert de Groot, and Reiner Sustmann
Chemistry - A European Journal, 2007, Volume 13, Number 15, Page 4230
Patrícia Budni, Maria Noemia Martins de Lima, Manuela Polydoro, José Cláudio Fonseca Moreira, Nadja Schroder, and Felipe Dal-Pizzol
Neurochemical Research, 2007, Volume 32, Number 6, Page 965
Ryan M. Hutcheson, Mark D. Engelmann, and I. Francis Cheng
BioMetals, 2005, Volume 18, Number 1, Page 43
Ursula Rauen, Uta Kerkweg, Monica C Wusteman, and Herbert de Groot
Cornea, 2006, Volume 25, Number 1, Page 68
Ryan Hutcheson, Mark D. Engelmann, and I. Francis Cheng
BioMetals, 2004, Volume 17, Number 6, Page 605

Comments (0)

Please log in or register to comment.
Log in