Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred


IMPACT FACTOR 2018: 3.014
5-year IMPACT FACTOR: 3.162

CiteScore 2018: 3.09

SCImago Journal Rank (SJR) 2018: 1.482
Source Normalized Impact per Paper (SNIP) 2018: 0.820

Online
ISSN
1437-4315
See all formats and pricing
More options …
Volume 383, Issue 3-4

Issues

A2E and Blue Light in the Retina: The Paradigm of Age-Related Macular Degeneration

H. Shaban / C. Richter
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/BC.2002.054

Abstract

The photoreceptors in the retina, designed to initiate the cascade of events which link the incoming light to the sensation of vision, are susceptible to damage by light, particularly blue light. The damage can lead to cell death and diseases. The turnover of retinal, an essential element of the visual process, is the basis of the events that lead to damage. Free retinal, absorbing in the blue region of the visible spectrum, is phototoxic, and is a precursor of the (photo)toxic compound A2E, which specifically targets cytochrome oxidase and thereby induces cell death by apoptosis. Cell death induced by A2E in the dark is prevented by negatively charged phospholipids. The blue lightfiltering molecules lutein and zeaxanthin are tailormade substances protecting the retina. In vitro, they protect cytochrome oxidase against the permanent damage caused by A2E in combination with light. These novel findings should enable us to prevent or cure the dry form of agerelated macular degeneration, the leading cause of severe visual impairment in humans living in developed countries.

About the article

Published Online: 2005-06-01

Published in Print: 2002-04-12


Citation Information: Biological Chemistry, Volume 383, Issue 3-4, Pages 537–545, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2002.054.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Jiunn-Liang Chen, Chun-Tzu Hung, Joseph Jordan Keller, Hsien-Chung Lin, and Yu-Jen Wu
BMC Ophthalmology, 2019, Volume 19, Number 1
[2]
Marta Gea, Tiziana Schilirò, Paola Iacomussi, Raffaella Degan, Sara Bonetta, and Giorgio Gilli
Journal of Toxicology and Environmental Health, Part A, 2018, Page 1
[3]
Olaf Strauss
Physiological Reviews, 2005, Volume 85, Number 3, Page 845
[4]
Richard HW Funk
World Journal of Ophthalmology, 2014, Volume 4, Number 3, Page 29
[5]
Stephen Westland, Qianqian Pan, and SooJin Lee
Coloration Technology, 2017
[6]
Paul S. Bernstein, Binxing Li, Preejith P. Vachali, Aruna Gorusupudi, Rajalekshmy Shyam, Bradley S. Henriksen, and John M. Nolan
Progress in Retinal and Eye Research, 2016, Volume 50, Page 34
[7]
N. M. Haralampus-Grynaviski, L. E. Lamb, C. M. R. Clancy, C. Skumatz, J. M. Burke, T. Sarna, and J. D. Simon
Proceedings of the National Academy of Sciences, 2003, Volume 100, Number 6, Page 3179
[8]
D. R. Gollapalli and R. R. Rando
Proceedings of the National Academy of Sciences, 2004, Volume 101, Number 27, Page 10030
[9]
Barbara E.K. Klein, Jane A. McElroy, Ronald Klein, Kerri P. Howard, and Kristine E. Lee
Journal of Environmental Science and Health, Part A, 2013, Volume 48, Number 14, Page 1757
[10]
Hubert van den Bergh, Jean-Pierre Ballini, and Michel Sickenberg
Medical Laser Application, 2003, Volume 18, Number 1, Page 65
[12]
Helen L. Walls, Kelvin L. Walls, and Geza Benke
American Journal of Public Health, 2011, Volume 101, Number 12, Page 2222
[13]
Hamdy Shaban, Consuelo BorrÁs, JosÉ ViNa, and Christoph Richter
Experimental Eye Research, 2002, Volume 75, Number 1, Page 99
[14]
Claudia Brockmann, Marcus Schulz, and Thomas Laube
Journal of Cataract & Refractive Surgery, 2008, Volume 34, Number 7, Page 1161
[15]
Norman B. Javitt
Steroids, 2008, Volume 73, Number 2, Page 149
[16]
A. Brock Roller, Vinit B. Mahajan, H. Culver Boldt, Michael D. Abramoff, Stephen R. Russell, and James C. Folk
Ophthalmology, 2010, Volume 117, Number 7, Page 1381
[17]
Norman I. Krinsky, John T. Landrum, and Richard A. Bone
Annual Review of Nutrition, 2003, Volume 23, Number 1, Page 171
[18]
A. R. Wielgus, R. J. Collier, E. Martin, F. B. Lih, K. B. Tomer, C. F. Chignell, and J. E. Roberts
Photochemical & Photobiological Sciences, 2010, Volume 9, Number 11, Page 1505
[19]
Jeffrey R. Kanofsky, Paul D. Sima, and Christoph Richter
Photochemistry and Photobiology, 2007, Volume 77, Number 3, Page 235
[20]
Laura E. Lamb and John D. Simon
Photochemistry and Photobiology, 2007, Volume 79, Number 2, Page 127
[21]
R H W Funk, E-M Kniep, and C Röhlecke
Eye, 2007, Volume 21, Page S38
[22]
Jeffrey R. Kanofsky, Paul D. Sima, and Christoph Richter
Photochemistry and Photobiology, 2003, Volume 77, Number 3, Page 235
[23]
Laura E. Lamb and John D. Simon
Photochemistry and Photobiology, 2004, Volume 79, Number 2, Page 127
[24]
Carolyn Glazer-Hockstein and Joshua L. Dunaief
Retina, 2006, Volume 26, Number 1, Page 1

Comments (0)

Please log in or register to comment.
Log in