Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

IMPACT FACTOR 2018: 3.014
5-year IMPACT FACTOR: 3.162

CiteScore 2018: 3.09

SCImago Journal Rank (SJR) 2018: 1.482
Source Normalized Impact per Paper (SNIP) 2018: 0.820

See all formats and pricing
More options …
Volume 383, Issue 3-4


Interactions of Nitric Oxide and Peroxynitrite with Low-Density Lipoprotein

H. Rubbo / A. Trostchansky / H. Botti / C. Batthyány
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/BC.2002.055


Nitric oxide (NO) is a free radical species that diffuses and concentrates in the hydrophobic core of lowdensity lipoprotein (LDL) to serve as a potent inhibitor of lipid oxidation processes. Peroxynitrite (PN), the product of the diffusionlimited reaction between NO and superoxide (O2), represents a relevant mediator of oxidative modifications in LDL. The focus of this review is the analysis of interactions between NO and PN and its secondary reactions with oxygen radicals on LDL oxidation, which are relevant in the development of the early steps as well as progression of atherosclerosis. We propose that the balance between rates of PN and NO production, which greatly depends on oxidative stress processes within the vascular wall, will critically determine the final extent of oxidative LDL modifications leading or not to scavenger receptormediated LDL uptake and foam cell formation.

About the article

Published Online: 2005-06-01

Published in Print: 2002-04-12

Citation Information: Biological Chemistry, Volume 383, Issue 3-4, Pages 547–552, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2002.055.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Bongkun Choi, Min-Kyung Shin, Eun-Young Kim, Ji-Eun Park, Halim Lee, Seong Who Kim, Jae-Kwan Song, and Eun-Ju Chang
Frontiers in Immunology, 2019, Volume 10
Carmela Colica, Maja Milanović, Nataša Milić, Vincenzo Aiello, Antonino De Lorenzo, and Ludovico Abenavoli
Natural Product Communications, 2018, Volume 13, Number 9, Page 1934578X1801300
Arnold G. Herman and Salvador Moncada
European Heart Journal, 2005, Volume 26, Number 19, Page 1945
Pál Pacher, Joseph S. Beckman, and Lucas Liaudet
Physiological Reviews, 2007, Volume 87, Number 1, Page 315
Claudia PMS de Oliveira
World Journal of Gastroenterology, 2006, Volume 12, Number 12, Page 1905
Toshihito Mitsui, Tomoyuki Ito, Yusuke Sasaki, Takashi Kawasaki, Takeshi Nakamura, Yukihide Nishimura, Tatsuru Ibusuki, Yukiharu Higuchi, Sayoko Hosoe, Fumiaki Ito, and Fumihiro Tajima
Spinal Cord Series and Cases, 2017, Volume 3, Page 17015
Trinity J. Bivalacqua, Mustafa F. Usta, Hunter C. Champion, Philip J. Kadowitz, and Wayne J. G. Hellstrom
Journal of Andrology, 2003, Volume 24, Number S6, Page S17
T. Padró, C. Mendieta, and L. Badimon
Hipertensión y Riesgo Vascular, 2005, Volume 22, Number 4, Page 173
Ming Gong, Melinda Wilson, Thomas Kelly, Wen Su, James Dressman, Jeanie Kincer, Sergey V. Matveev, Ling Guo, Theresa Guerin, Xiang-An Li, Weifei Zhu, Annette Uittenbogaard, and Eric J. Smart
Journal of Clinical Investigation, 2003, Volume 111, Number 10, Page 1579
Silvia M Sanguinetti, Carlos Batthyány, Andrés Trostchansky, Horacio Botti, Graciela I López, Regina L.W Wikinski, Homero Rubbo, and Laura E Schreier
Archives of Biochemistry and Biophysics, 2004, Volume 423, Number 2, Page 302
T. Padró, C. Mendieta, and L. Badimon
Hipertensión, 2005, Volume 22, Number 4, Page 173
Wei Yu, Yu-Cai Fu, and Wei Wang
Journal of Cellular Biochemistry, 2012, Volume 113, Number 3, Page 752
Gamze Yurdakan, Ishak Ozel Tekin, Mustafa Comert, Serefden Acikgoz, and Emine Yilmaz Sipahi
The Kaohsiung Journal of Medical Sciences, 2012, Volume 28, Number 1, Page 16
Manika Das and Dipak K. Das
Molecular Aspects of Medicine, 2010, Volume 31, Number 6, Page 503
Mustafa Comert, Emine Yilmaz Sipahi, Huseyin Ustun, Fulden Isikdemir, Gamze Numanoglu, Figen Barut, Hanife Altunkaya, Yetkin Ozer, Ferruh Niyazi Ayoglu, Tunc Hakan Sipahi, Ishak Ozel Tekin, and Z. Nur Banoglu
European Journal of Pharmacology, 2005, Volume 511, Number 2-3, Page 183
Dayami Lopez and Mark P. McLean
Molecular and Cellular Endocrinology, 2006, Volume 247, Number 1-2, Page 22
Andrés Trostchansky, Gerardo Ferrer-Sueta, Carlos Batthyány, Horacio Botti, Ines Batinić-Haberle, Rafael Radi, and Homero Rubbo
Free Radical Biology and Medicine, 2003, Volume 35, Number 10, Page 1293
Juliana Hwang, Jian Wang, Paolo Morazzoni, Howard N. Hodis, and Alex Sevanian
Free Radical Biology and Medicine, 2003, Volume 34, Number 10, Page 1271
J.P.F. Chin-Dusting, L. Willems, and D.M. Kaye
Pharmacology & Therapeutics, 2007, Volume 116, Number 3, Page 428
Enguo Fan, Lijuan Zhang, Sha Jiang, and Yuhua Bai
Journal of Medicinal Food, 2008, Volume 11, Number 4, Page 610
Gordon A. A. Ferns
Proceedings of the Nutrition Society, 2008, Volume 67, Number 02, Page 223
Tilo Kraemer, Inthanongsack Prakosay, Rahul A. Date, Helmut Sies, and Tankred Schewe
Biological Chemistry, 2004, Volume 385, Number 9
Farhan Majeed and Michael Miller
Future Cardiology, 2007, Volume 3, Number 3, Page 243
Jitbanjong Tangpong, Marsha P. Cole, Rukhsana Sultana, Steven Estus, Mary Vore, William St. Clair, Suvina Ratanachaiyavong, Daret K. St. Clair, and D. Allan Butterfield
Journal of Neurochemistry, 2007, Volume 100, Number 1, Page 191
Kaya Horasanli, Ugur Boylu, Muammer Kendirci, and Cengiz Miroglu
Asian Journal of Andrology, 2008, Volume 10, Number 1, Page 28
Takashi Ichiyanagi, Yoshihiko Hatano, Seiichi Matsuo, and Tetsuya Konishi
CHEMICAL & PHARMACEUTICAL BULLETIN, 2004, Volume 52, Number 11, Page 1312

Comments (0)

Please log in or register to comment.
Log in