Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred


IMPACT FACTOR 2018: 3.014
5-year IMPACT FACTOR: 3.162

CiteScore 2018: 3.09

SCImago Journal Rank (SJR) 2018: 1.482
Source Normalized Impact per Paper (SNIP) 2018: 0.820

Online
ISSN
1437-4315
See all formats and pricing
More options …
Volume 383, Issue 3-4

Issues

The Cellular Hydration State: A Critical Determinant for Cell Death and Survival

F. Schliess / D. Häussinger
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/BC.2002.059

Abstract

Alterations in cellular hydration not only contribute to metabolic regulation, but also critically determine the cellular response to different kinds of stress. Whereas cell swelling triggers anabolic pathways and protects cells from heat and oxidative challenge, cellular dehydration contributes to insulin resistance and catabolism and increases the cellular susceptibility to stressinduced damage. Intracellular accumulation of organic osmolytes, cell cycle delay and the expression of heat shock proteins provide cellular tolerance to hyperosmolarity and protect against stressors under dehydrating conditions. This article discusses some mechanisms by which alterations in cell hydration contribute to cytoprotection or cell damage. In addition, the close relationship between osmotic and oxidative stress and the contribution of isoosmotic shrinkage to apoptotic cell death are considered.

About the article

Published Online: 2005-06-01

Published in Print: 2002-04-12


Citation Information: Biological Chemistry, Volume 383, Issue 3-4, Pages 577–583, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2002.059.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[2]
Sandy Slow, Jane Elmslie, and Michael Lever
The American Journal of Clinical Nutrition, 2008, Volume 88, Number 1, Page 247
[3]
Lars Hoffmann, Gernot Brauers, Thor Gehrmann, Dieter Häussinger, Ertan Mayatepek, Freimut Schliess, and Bernd C. Schwahn
American Journal of Physiology-Gastrointestinal and Liver Physiology, 2013, Volume 304, Number 9, Page G835
[4]
Somayeh Shadmehr, Seyed Reza FatemiTabatabaei, Shima Hosseinifar, Mohammad Reza Tabandeh, and Alireza Amiri
Theriogenology, 2017
[5]
Roland Reinehr, Stephan Becker, Andrea Höngen, and Dieter Haüssinger
Journal of Biological Chemistry, 2004, Volume 279, Number 23, Page 23977
[6]
Jae H. Choi, Jason Williams, Jaiesoon Cho, J. R. Falck, and Stephen B. Shears
Journal of Biological Chemistry, 2007, Volume 282, Number 42, Page 30763
[7]
Roland Reinehr, Stephan Becker, Juliane Braun, Andrea Eberle, Susanne Grether-Beck, and Dieter Haüssinger
Journal of Biological Chemistry, 2006, Volume 281, Number 32, Page 23150
[8]
Ling Yang, Jeff M. Reece, Jaiesoon Cho, Carl D. Bortner, and Stephen B. Shears
Journal of Biological Chemistry, 2008, Volume 283, Number 17, Page 11823
[9]
Vincent P. Georgescu, Tacito P. de Souza Junior, Christian Behrens, Marcelo P. Barros, Carlos Alves Bueno, Alan C. Utter, Lisa S. McAnulty, and Steven R. McAnulty
Applied Physiology, Nutrition, and Metabolism, 2017, Volume 42, Number 7, Page 694
[10]
Soumita Ghosh, Arjun Sengupta, Shobhona Sharma, Haripalsingh M. Sonawat, and Daniel Monleon
PLoS ONE, 2013, Volume 8, Number 9, Page e73113
[11]
Nikhil A. Gokhale, Angelika Zaremba, Agnes K. Janoshazi, Jeremy D. Weaver, and Stephen B. Shears
Biochemical Journal, 2013, Volume 453, Number 3, Page 413
[12]
Daniel Brandhorst, Heide Brandhorst, Vidya Maataoui, Adel Maataoui, and Paul R. V. Johnson
Apoptosis, 2013, Volume 18, Number 6, Page 681
[13]
Qian Garrett, Neeta Khandekar, Sharon Shih, Judith L. Flanagan, Peter Simmons, Joseph Vehige, and Mark D.P. Willcox
Experimental Eye Research, 2013, Volume 108, Page 33
[14]
Lawrence N. Diebel, David M. Liberati, Anna M. Ledgerwood, and Charles E. Lucas
Journal of Trauma and Acute Care Surgery, 2012, Volume 73, Number 1, Page 41
[15]
Roland Reinehr and Dieter Häussinger
Archives of Biochemistry and Biophysics, 2007, Volume 462, Number 2, Page 124
[16]
Osvaldo Fridman, Analía V Morales, Laura E Bortoni, Paula C Turk-Noceto, and Elio A Prieto
Journal of Biosciences, 2012, Volume 37, Number 1, Page 115
[17]
Freimut Schliess, Roland Reinehr, and Dieter Häussinger
FEBS Journal, 2007, Volume 274, Number 22, Page 5799
[18]
Dieter Häussinger and Roland Reinehr
Cellular Physiology and Biochemistry, 2011, Volume 28, Number 6, Page 1089
[19]
J. L. Chaytor, J. M. Tokarew, L. K. Wu, M. Leclere, R. Y. Tam, C. J. Capicciotti, L. Guolla, E. von Moos, C. S. Findlay, D. S. Allan, and R. N. Ben
Glycobiology, 2012, Volume 22, Number 1, Page 123
[20]
Michael Lever, Peter C.M Sizeland, Christopher M Frampton, and Stephen T Chambers
Clinical Biochemistry, 2004, Volume 37, Number 3, Page 184
[21]
Michael Lever, Wendy Atkinson, Peter M. George, and Stephen T. Chambers
Clinical Biochemistry, 2007, Volume 40, Number 11, Page 798
[22]
Michael Lever, Wendy Atkinson, Peter C.B. Sizeland, Stephen T. Chambers, and Peter M. George
Clinical Biochemistry, 2007, Volume 40, Number 7, Page 447
[23]
Michael Lever and Sandy Slow
Clinical Biochemistry, 2010, Volume 43, Number 9, Page 732
[24]
Michael Lever, Wendy Atkinson, Peter M. George, and Stephen T. Chambers
Clinical Biochemistry, 2007, Volume 40, Number 16-17, Page 1225
[25]
Michael Lever, Wendy Atkinson, Sandy Slow, Stephen T. Chambers, and Peter M. George
Clinical Biochemistry, 2009, Volume 42, Number 7-8, Page 706
[26]
Rafaela Fadoni Alponti, Leonardo Zambotti-Villela, Cristiane Murena-Nunes, Camila Eduardo Marinho, Renata do Amaral Olivo, and Paulo Flavio Silveira
Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 2005, Volume 141, Number 3, Page 336
[27]
Angela R. Hillman, Rebecca V. Vince, Lee Taylor, Lars McNaughton, Nigel Mitchell, and Jason Siegler
Applied Physiology, Nutrition, and Metabolism, 2011, Volume 36, Number 5, Page 698
[28]
[29]
Jesús A. Rosas-Rodríguez and Elisa M. Valenzuela-Soto
Life Sciences, 2010, Volume 87, Number 17-18, Page 515
[30]
Michael Lever, Peter M. George, Warwick J. Dellow, Russell S. Scott, and Stephen T. Chambers
Metabolism, 2005, Volume 54, Number 1, Page 1
[31]
Sergio Scapin, Silvia Leoni, Silvana Spagnuolo, Davide Gnocchi, Paolo De Vito, Paolo Luly, Jens Z. Pedersen, and Sandra Incerpi
Steroids, 2010, Volume 75, Number 8-9, Page 576
[32]
P. Ferenci
Digestive and Liver Disease, 2005, Volume 37, Number 10, Page 805
[33]
Franziska Grafe, Wolfgang Wohlrab, Reinhard H Neubert, and Matthias Brandsch
European Journal of Pharmaceutics and Biopharmaceutics, 2004, Volume 57, Number 2, Page 337
[34]
Samuele Marcora, Andrew Lemmey, and Peter Maddison
Clinical Nutrition, 2005, Volume 24, Number 3, Page 442
[35]
Kanti Bhooshan Pandey and Syed Ibrahim Rizvi
Arabian Journal of Chemistry, 2011, Volume 4, Number 3, Page 293
[36]
Dashuang Fan, Xueqin An, and Weiguo Shen
Journal of Chemical & Engineering Data, 2011, Volume 56, Number 12, Page 4480
[37]
Laura Sánchez-Hernández, María Castro-Puyana, María Luisa Marina, and Antonio L. Crego
ELECTROPHORESIS, 2011, Volume 32, Number 11, Page 1394
[38]
Sandy Slow, Michael Lever, Martin B. Lee, Peter M. George, and Stephen T. Chambers
The International Journal of Biochemistry & Cell Biology, 2004, Volume 36, Number 5, Page 870
[39]
Stephen B. Shears, Nikhil A. Gokhale, Huanchen Wang, and Angelika Zaremba
Advances in Enzyme Regulation, 2011, Volume 51, Number 1, Page 13
[40]
Daniel A. Ateya, Frederick Sachs, and Susan Z. Hua
MRS Proceedings, 2004, Volume 845
[41]
Dirk Graf, Katrin Haselow, Ivo Münks, Johannes G. Bode, and Dieter Häussinger
Biological Chemistry, 2010, Volume 391, Number 10
[42]
Per Magne Ueland
Journal of Inherited Metabolic Disease, 2011, Volume 34, Number 1, Page 3
[43]
Michael Lever, Peter M. George, Sandy Slow, Jane L. Elmslie, Russell S. Scott, A. Mark Richards, John N. Fink, and Stephen T. Chambers
Cardiovascular Drugs and Therapy, 2009, Volume 23, Number 5, Page 395
[44]
Wilfried Siefken, Stefanie Carstensen, Gunja Springmann, Klaus-Peter Wittern, Horst Wenck, Franz Stäb, Gerhard Sauermann, Volker Schreiner, Thomas Doering, Guido Janeke, Oliver Bleck, Hans Steinhart, and Peter Höger
Journal of Investigative Dermatology, 2003, Volume 121, Number 2, Page 354
[45]
Jason G. McCoy, Lucas J. Bailey, Yi Han Ng, Craig A. Bingman, Russell Wrobel, Andreas P. M. Weber, Brian G. Fox, and George N. Phillips
Proteins: Structure, Function, and Bioinformatics, 2009, Volume 74, Number 2, Page 368
[46]
Jan Albrecht and Michael D. Norenberg
Hepatology, 2006, Volume 44, Number 4, Page 788
[47]
C. Collin, B. Gautier, O. Gaillard, P. Hallegot, S. Chabane, P. Bastien, M. Peyron, M. Bouleau, S. Thibaut, F. Pruche, A. Duranton, and B. A. Bernard
International Journal of Cosmetic Science, 2006, Volume 28, Number 4, Page 289
[48]
R. Reinehr and D. Haussinger
Acta Physiologica, 2006, Volume 187, Number 1-2, Page 199
[49]
Freimut Schliess and Dieter Häussinger
Signal Transduction, 2005, Volume 5, Number 6, Page 297
[50]
Olaf Dransfeld, Thor Gehrmann, Karl Kohrer, Gerald Kircheis, Claudia Holneicher, Dieter Haussinger, and Matthias Wettstein
Liver International, 2005, Volume 25, Number 6, Page 1243

Comments (0)

Please log in or register to comment.
Log in