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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

12 Issues per year


IMPACT FACTOR 2016: 3.273

CiteScore 2016: 3.01

SCImago Journal Rank (SJR) 2016: 1.679
Source Normalized Impact per Paper (SNIP) 2016: 0.800

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ISSN
1437-4315
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Volume 383, Issue 3-4 (Apr 2002)

Issues

Comparing β-Carotene, Vitamin E and Nitric Oxide as Membrane Antioxidants

F.Q. Schafer / H.P. Wang / E.E. Kelley / K.L. Cueno / S.M. Martin and G.R. Buettner
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/BC.2002.069

Abstract

Singlet oxygen initiates lipid peroxidation via a nonfree radical mechanism by reacting directly with unsaturated lipids to form lipid hydroperoxides (LOOHs). These LOOHs can initiate free radical chain reactions leading to membrane leakage and cell death. Here we compare the ability and mechanism by which three smallmolecule membrane antioxidants (βcarotene, αtocopherol and nitric oxide) inhibit lipid peroxidation in membranes. We demonstrate that βcarotene provides protection against singlet oxygenmediated lipid peroxidation, but does not slow free radicalmediated lipid peroxidation. α Tocopherol does not protect cells from singlet oxygen, but does inhibit free radical formation in cell membranes. Nitric oxide provides no direct protection against singlet oxygen exposure, but is an exceptional chainbreaking antioxidant as evident from its ability to blunt oxygen consumption during free radical mediated lipid peroxidation. These three smallmolecule antioxidants appear to have complementary mechanisms for the protection of cell membranes from detrimental oxidations.

About the article

Published Online: 2005-06-01

Published in Print: 2002-04-12


Citation Information: Biological Chemistry, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2002.069.

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