Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

IMPACT FACTOR 2018: 3.014
5-year IMPACT FACTOR: 3.162

CiteScore 2018: 3.09

SCImago Journal Rank (SJR) 2018: 1.482
Source Normalized Impact per Paper (SNIP) 2018: 0.820

See all formats and pricing
More options …
Volume 383, Issue 3-4


Comparing β-Carotene, Vitamin E and Nitric Oxide as Membrane Antioxidants

F.Q. Schafer / H.P. Wang / E.E. Kelley / K.L. Cueno / S.M. Martin and G.R. Buettner
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/BC.2002.069


Singlet oxygen initiates lipid peroxidation via a nonfree radical mechanism by reacting directly with unsaturated lipids to form lipid hydroperoxides (LOOHs). These LOOHs can initiate free radical chain reactions leading to membrane leakage and cell death. Here we compare the ability and mechanism by which three smallmolecule membrane antioxidants (βcarotene, αtocopherol and nitric oxide) inhibit lipid peroxidation in membranes. We demonstrate that βcarotene provides protection against singlet oxygenmediated lipid peroxidation, but does not slow free radicalmediated lipid peroxidation. α Tocopherol does not protect cells from singlet oxygen, but does inhibit free radical formation in cell membranes. Nitric oxide provides no direct protection against singlet oxygen exposure, but is an exceptional chainbreaking antioxidant as evident from its ability to blunt oxygen consumption during free radical mediated lipid peroxidation. These three smallmolecule antioxidants appear to have complementary mechanisms for the protection of cell membranes from detrimental oxidations.

About the article

Published Online: 2005-06-01

Published in Print: 2002-04-12

Citation Information: Biological Chemistry, Volume 383, Issue 3-4, Pages 671–681, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2002.069.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Ana Puga, María Pajares, Gregorio Varela-Moreiras, and Teresa Partearroyo
Nutrients, 2018, Volume 11, Number 1, Page 35
Sharon G Curhan, Konstantina M Stankovic, Roland D Eavey, Molin Wang, Meir J Stampfer, and Gary C Curhan
The American Journal of Clinical Nutrition, 2015, Volume 102, Number 5, Page 1167
Yoon-Hyeong Choi, Josef M Miller, Katherine L Tucker, Howard Hu, and Sung Kyun Park
The American Journal of Clinical Nutrition, 2014, Volume 99, Number 1, Page 148
Kaouthar Feki, Sana Tounsi, and Faiçal Brini
Spanish Journal of Agricultural Research, 2017, Volume 15, Number 4, Page e0805
Jorge Alberto Vieira Costa, Gisele Medianeira Barbieri Moro, Daza de Moraes Vaz Batista Filgueira, Emanuela Corsini, and Telma Elita Bertolin
Industrial Biotechnology, 2017, Volume 13, Number 5, Page 244
Nicholas M. Brown, Sean M. Martin, Nick Maurice, Tomomi Kuwana, and C. Michael Knudson
Journal of Biological Chemistry, 2007, Volume 282, Number 4, Page 2144
Muhammad Farooq, Nirmali Gogoi, Mubshar Hussain, Sharmistha Barthakur, Sreyashi Paul, Nandita Bharadwaj, Hussein M. Migdadi, Salem S. Alghamdi, and Kadambot H.M. Siddique
Plant Physiology and Biochemistry, 2017
Larbi Allai, Xavier Druart, Noureddine Louanjli, Jesus Contell, Boubker Nasser, and Bouchra El Amiri
Small Ruminant Research, 2017, Volume 151, Page 16
Anna Wyrwicka, Magdalena Urbaniak, and Haitao Shi
PLOS ONE, 2016, Volume 11, Number 6, Page e0157782
Christoph V. Suschek and Christian Opländer
Clinical Plasma Medicine, 2016, Volume 4, Number 1, Page 1
Koushik Chakraborty, Sujit K. Bishi, Nisha Goswami, Amrit L. Singh, and Pratap V. Zala
Environmental and Experimental Botany, 2016, Volume 128, Page 79
Anna Wyrwicka, Steffani Steffani, and Magdalena Urbaniak
Ecohydrology & Hydrobiology, 2014, Volume 14, Number 1, Page 75
Armin Saed-Moucheshi, Avat Shekoofa, and Mohammad Pessarakli
Journal of Plant Nutrition, 2014, Volume 37, Number 10, Page 1573
F. M. El-Demerdash, M. I. Yousef, F. S. Kedwany, and H. H. Baghdadi
Journal of Environmental Science and Health, Part B, 2004, Volume 39, Number 3, Page 443
A.V. Alessenko, M.A. Shupik, U.A. Gutner, A.E. Bugrova, L.B. Dudnik, L.N. Shingarova, A. Mikoyan, and A.F. Vanin
FEBS Letters, 2005, Volume 579, Number 25, Page 5571
Ivan Spasojevic, Milos Mojovic, Aleksandar Ignjatovic, and Goran Bacic
Journal of the Serbian Chemical Society, 2011, Volume 76, Number 5, Page 647
B. Gopinath, V. M. Flood, C. M. McMahon, G. Burlutsky, C. Spankovich, L. J. Hood, and Paul Mitchell
The journal of nutrition, health & aging, 2011, Volume 15, Number 10, Page 896
Hiroshi Yoshii, Yukie Yoshii, Tatsuya Asai, Takako Furukawa, Shinichi Takaichi, and Yasuhisa Fujibayashi
Biochemical and Biophysical Research Communications, 2012, Volume 417, Number 1, Page 640
Colleen G. Le Prell, Patricia M. Gagnon, David C. Bennett, and Kevin K. Ohlemiller
Translational Research, 2011, Volume 158, Number 1, Page 38
Han-Qing Ye, Lu Gan, Xiang-Liang Yang, and Hui-Bi Xu
Journal of Ethnopharmacology, 2006, Volume 103, Number 3, Page 366
Konstantin B. Shumaev, Andrey A. Gubkin, Vladimir A. Serezhenkov, Irina I. Lobysheva, Olga V. Kosmachevskaya, Enno K. Ruuge, Vadim Z. Lankin, Alexey F. Topunov, and Anatoly F. Vanin
Nitric Oxide, 2008, Volume 18, Number 1, Page 37
Ivan Spasojević
Critical Reviews in Clinical Laboratory Sciences, 2011, Volume 48, Number 3, Page 114
Anna Wyrwicka and Maria Skłodowska
Environmental and Experimental Botany, 2006, Volume 56, Number 2, Page 198
Burcu Seckin, Ismail Turkan, Askim Hediye Sekmen, and Ceyda Ozfidan
Environmental and Experimental Botany, 2010, Volume 69, Number 1, Page 76
Stephen G. Hummel, Anthony J. Fischer, Sean M. Martin, Freya Q. Schafer, and Garry R. Buettner
Free Radical Biology and Medicine, 2006, Volume 40, Number 3, Page 501
Norman I. Krinsky and Elizabeth J. Johnson
Molecular Aspects of Medicine, 2005, Volume 26, Number 6, Page 459
Juan M. Hernández-Martínez, Guadalupe Domínguez, Sugela Blancas, and Julio Morán
Neurochemical Research, 2011, Volume 36, Number 4, Page 677
Ruitang Deng and Te-Jin Chow
Cardiovascular Therapeutics, 2010, Volume 28, Number 4, Page e33
F. Hosseini, M.K. Gharib Naseri, M. Badavi, M.A. Ghaffari, H. Shahbazian, and I. Rashidi
Pakistan Journal of Biological Sciences, 2009, Volume 12, Number 16, Page 1140
Sara A. Arscott and Sherry A. Tanumihardjo
Comprehensive Reviews in Food Science and Food Safety, 2010, Volume 9, Number 2, Page 223
H. Doulaty Baneh ., S.A. Mohammadi ., M. Labra ., A. Nazemieh ., F.De Mattia ., and M. Mardi .
Pakistan Journal of Biological Sciences, 2007, Volume 10, Number 11, Page 1855
S. A. Bashandy and I. M. Alhazza
Journal of Pharmacology and Toxicology, 2008, Volume 3, Number 6, Page 457
Iwona Błaszczyk, Ewa Grucka-Mamczar, Sławomir Kasperczyk, and Ewa Birkner
Biological Trace Element Research, 2009, Volume 129, Number 1-3, Page 229
Vilailak Klompong, Soottawat Benjakul, Duangporn Kantachote, Kirby Dale Hayes, and Fereidoon Shahidi
International Journal of Food Science & Technology, 2008, Volume 43, Number 6, Page 1019
K. B. Shumaev, A. A. Gubkin, S. A. Gubkina, L. L. Gudkov, I. V. Sviryaeva, A. A. Timoshin, A. F. Topunov, A. F. Vanin, and E. K. Ruuge
Biophysics, 2006, Volume 51, Number 3, Page 423

Comments (0)

Please log in or register to comment.
Log in