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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred


IMPACT FACTOR 2017: 3.022

CiteScore 2018: 3.09

SCImago Journal Rank (SJR) 2018: 1.482
Source Normalized Impact per Paper (SNIP) 2018: 0.820

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ISSN
1437-4315
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Volume 383, Issue 5

Issues

Stage-Specific Antimalarial Activity of Cysteine Protease Inhibitors

Bhaskar R. Shenai / Andrey V. Semenov / Philip J. Rosenthal
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/BC.2002.089

Abstract

Cysteine proteases of the malaria parasite Plasmodium falciparum, known as falcipains, are promising targets for antimalarial chemotherapy. We evaluated cultured parasites for the stagespecific expression of cysteine proteases and sensitivity to cysteine protease inhibitors. Protease activity and inhibitor sensitivity varied markedly over time. Cysteine protease activity was greatest in early trophozoites, while sensitivity to cysteine protease inhibitors was greatest in mature trophozoites. Our results indicate the importance of considering the stagespecific effects of antimalarials and are consistent with the conclusion that the principal antimalarial activity of cysteine protease inhibitors is due to a block in hemoglobin hydrolysis.

About the article

Published Online: 2005-06-01

Published in Print: 2002-05-15


Citation Information: Biological Chemistry, Volume 383, Issue 5, Pages 843–847, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2002.089.

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