Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

IMPACT FACTOR 2017: 3.022

CiteScore 2018: 3.09

SCImago Journal Rank (SJR) 2018: 1.482
Source Normalized Impact per Paper (SNIP) 2018: 0.820

See all formats and pricing
More options …
Volume 383, Issue 5


Stage-Specific Antimalarial Activity of Cysteine Protease Inhibitors

Bhaskar R. Shenai / Andrey V. Semenov / Philip J. Rosenthal
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/BC.2002.089


Cysteine proteases of the malaria parasite Plasmodium falciparum, known as falcipains, are promising targets for antimalarial chemotherapy. We evaluated cultured parasites for the stagespecific expression of cysteine proteases and sensitivity to cysteine protease inhibitors. Protease activity and inhibitor sensitivity varied markedly over time. Cysteine protease activity was greatest in early trophozoites, while sensitivity to cysteine protease inhibitors was greatest in mature trophozoites. Our results indicate the importance of considering the stagespecific effects of antimalarials and are consistent with the conclusion that the principal antimalarial activity of cysteine protease inhibitors is due to a block in hemoglobin hydrolysis.

About the article

Published Online: 2005-06-01

Published in Print: 2002-05-15

Citation Information: Biological Chemistry, Volume 383, Issue 5, Pages 843–847, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2002.089.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Ebere Sonoiki, Caroline L. Ng, Marcus C. S. Lee, Denghui Guo, Yong-Kang Zhang, Yasheen Zhou, M. R. K. Alley, Vida Ahyong, Laura M. Sanz, Maria Jose Lafuente-Monasterio, Chen Dong, Patrick G. Schupp, Jiri Gut, Jenny Legac, Roland A. Cooper, Francisco-Javier Gamo, Joseph DeRisi, Yvonne R. Freund, David A. Fidock, and Philip J. Rosenthal
Nature Communications, 2017, Volume 8, Page 14574
P. S. Sijwali and P. J. Rosenthal
Proceedings of the National Academy of Sciences, 2004, Volume 101, Number 13, Page 4384
P. S. Sijwali, K. Kato, K. B. Seydel, J. Gut, J. Lehman, M. Klemba, D. E. Goldberg, L. H. Miller, and P. J. Rosenthal
Proceedings of the National Academy of Sciences, 2004, Volume 101, Number 23, Page 8721
Emir Salas-Sarduy, Aymara Cabrera-Muñoz, Ana Cauerhff, Yamile González-González, Sebastián A. Trejo, Agustina Chidichimo, Maria de los Angeles Chávez-Planes, and Juan José Cazzulo
Experimental Parasitology, 2013, Volume 135, Number 3, Page 611
Ying Pei, Jessica L. Miller, Scott E. Lindner, Ashley M. Vaughan, Motomi Torii, and Stefan H. I. Kappe
Cellular Microbiology, 2013, Volume 15, Number 9, Page 1508
Uttam Rajaram Mane, Ramesh C Gupta, Sunil Sadanand Nadkarni, Rajani R Giridhar, Prashant Prakash Naik, and Mange R Yadav
Expert Opinion on Therapeutic Patents, 2013, Volume 23, Number 2, Page 165
Asish K. Bhattacharya and Kalpeshkumar C. Rana
Bioorganic & Medicinal Chemistry, 2011, Volume 19, Number 23, Page 7129
Jeanne A. Geyer, Sean T. Prigge, and Norman C. Waters
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2005, Volume 1754, Number 1-2, Page 160
Philip J. Rosenthal
International Journal for Parasitology, 2004, Volume 34, Number 13-14, Page 1489
Godfrey Lisk, Margaret Pain, Morgan Sellers, Philip A. Gurnev, Ajay D. Pillai, Sergey M. Bezrukov, and Sanjay A. Desai
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2010, Volume 1798, Number 9, Page 1679
C. Gelhaus, R. Vicik, R. Hilgenfeld, C.L. Schmidt, M. Leippe, and T. Schirmeister
Biological Chemistry, 2004, Volume 385, Number 5
Kesara Na-Bangchang and Juntra Karbwang
Fundamental & Clinical Pharmacology, 2009, Volume 23, Number 4, Page 387
Rui Kuang, Jianying Gu, Hong Cai, and Yufeng Wang
Genetica, 2009, Volume 136, Number 1, Page 189

Comments (0)

Please log in or register to comment.
Log in