Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

12 Issues per year

IMPACT FACTOR 2017: 3.022

CiteScore 2017: 2.81

SCImago Journal Rank (SJR) 2017: 1.562
Source Normalized Impact per Paper (SNIP) 2017: 0.705

See all formats and pricing
More options …
Volume 383, Issue 6


Exocyclic DNA Adducts as Oxidative Stress Markers in Colon Carcinogenesis: Potential Role of Lipid Peroxidation, Dietary Fat and Antioxidants

Helmut Bartsch / Jagadeesan Nair / Robert W. Owen
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/BC.2002.098


Molecular pathways to colorectal cancer involve multiple genetic changes, whereby extensive oxyradical damage causes mutations in cancerrelated genes and leads to a cycle of cell death and regeneration. Besides direct oxidative DNAdamage, reactive oxygen and nitrogen species can induce etheno ()DNA adducts mainly via trans-4-hydroxy-2-nonenal, generated as the major aldehyde by lipid peroxidation (LPO) of ω-6 PUFAs. Patients with familial adenomatous polyposis (FAP) develop multiple colorectal adenomas. In affected tissues increased LPO could be triggered due to increased arachidonic acid metabolism as a result of elevated cyclooxygenases. Our studies demonstrated an increased DNA adduct level in affected colon epithelia of FAP patients. DNA adducts are promutagenic and can cause genomic instability that drives colorectal adenoma to malignancy. We have further investigated the potential chemopreventive properties of olive oil and its polyphenolic components. Mediterranean diet, of which olive oil is a major fatty acid source, has protective effects against human breast and colorectal cancers. Olive oil extracts and the newly identified lignan fractions showed high antioxidant capacity in vitro. As DNA adducts are biomarkers for oxidative stress and LPO induced DNA damage, they can verify the efficacy of newly identified antioxidants, e.g. from olive oil, as chemopreventive agents against colon carcinogenesis.

About the article

Published Online: 2005-06-01

Published in Print: 2002-06-26

Citation Information: Biological Chemistry, Volume 383, Issue 6, Pages 915–921, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2002.098.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

A. Martin Agnoux, A. El Ghaziri, T. Moyon, A. Pagniez, A. David, G. Simard, P. Parnet, E.M. Qannari, D. Darmaun, J.-P. Antignac, and M.-C. Alexandre-Gouabau
The Journal of Nutritional Biochemistry, 2017
Yang Yu, Pengcheng Wang, Yuxiang Cui, and Yinsheng Wang
Analytical Chemistry, 2017
Bodo Speckmann, Hans-Jürgen Bidmon, Antonio Pinto, Martin Anlauf, Helmut Sies, and Holger Steinbrenner
Journal of Biological Chemistry, 2011, Volume 286, Number 12, Page 10764
Laurent Gros, Andrei V. Maksimenko, Cyril V. Privezentzev, Jacques Laval, and Murat K. Saparbaev
Journal of Biological Chemistry, 2004, Volume 279, Number 17, Page 17723
C Balaji, J Muthukumaran, and N Nalini
Human & Experimental Toxicology, 2014, Volume 33, Number 12, Page 1253
Andrej Veljković, Goran Stanojević, Branko Branković, Dušica Pavlović, Ivana Stojanović, Tatjana Cvetković, Tatjana Jevtović, Dušan Sokolović, Jelena Bašić, Milena Despotović, Branka Đorđević, and Gordana Kocić
Acta Medica Medianae, 2016, Volume 55, Number 3, Page 32
Yang Yu, Yuxiang Cui, Laura J. Niedernhofer, and Yinsheng Wang
Chemical Research in Toxicology, 2016, Volume 29, Number 12, Page 2008
Beate Pfundstein, Roswitha Haubner, Gerd Würtele, Nicole Gehres, Cornelia M. Ulrich, and Robert W. Owen
Journal of Agricultural and Food Chemistry, 2014, Volume 62, Number 42, Page 10264
Athanasios Valavanidis, Thomais Vlachogianni, Konstantinos Fiotakis, and Spyridon Loridas
International Journal of Environmental Research and Public Health, 2013, Volume 10, Number 9, Page 3886
Christopher G. Smith, Hannah West, Rebecca Harris, Shelley Idziaszczyk, Timothy S. Maughan, Richard Kaplan, Susan Richman, Philip Quirke, Matthew Seymour, Valentina Moskvina, Verena Steinke, Peter Propping, Frederik J. Hes, Juul Wijnen, and Jeremy P. Cheadle
JNCI: Journal of the National Cancer Institute, 2013, Volume 105, Number 16, Page 1249
Vinicius Kannen, Dalila L. Zanette, Cleverson R. Fernandes, Frederico R. Ferreira, Tassiana Marini, Milene C. Carvalho, Marcus L. Brandão, Jorge Elias Junior, Fernando M. Mauad, Wilson A. Silva, Helga Stopper, and Sérgio B. Garcia
Toxicology Letters, 2012, Volume 213, Number 2, Page 135
Helmut Bartsch and Jagadeesan Nair
Cancer Detection and Prevention, 2004, Volume 28, Number 6, Page 385
Biomedical and Environmental Sciences, 2008, Volume 21, Number 4, Page 286
Rosa M. Álvarez Álvarez and Núria Mach Casellas
Revista Española de Nutrición Humana y Dietética, 2011, Volume 15, Number 4, Page 189
Verena Juliana Koller, Brigitte Marian, Reinhard Stidl, Armen Nersesyan, Heike Winter, Tatjana Simić, Gerhard Sontag, and Siegfried Knasmüller
Food and Chemical Toxicology, 2008, Volume 46, Number 4, Page 1221
Y. Knöbel, A. Weise, M. Glei, W. Sendt, U. Claussen, and B.L. Pool-Zobel
Food and Chemical Toxicology, 2007, Volume 45, Number 5, Page 804
R.W Owen, R Haubner, W Mier, A Giacosa, W.E Hull, B Spiegelhalder, and H Bartsch
Food and Chemical Toxicology, 2003, Volume 41, Number 5, Page 703
Julian R. Sampson and Natalie Jones
Best Practice & Research Clinical Gastroenterology, 2009, Volume 23, Number 2, Page 209
Akio Kobori, Jumpei Morita, Masato Ikeda, Asako Yamayoshi, and Akira Murakami
Bioorganic & Medicinal Chemistry Letters, 2009, Volume 19, Number 13, Page 3657
Farid Khallouki, Luisa Mannina, Stéphane Viel, and Robert W. Owen
Food Chemistry, 2008, Volume 110, Number 1, Page 57
Tamar Paz-Elizur, Ziv Sevilya, Yael Leitner-Dagan, Dalia Elinger, Laila C. Roisman, and Zvi Livneh
Cancer Letters, 2008, Volume 266, Number 1, Page 60
Helmut Bartsch and Jagadeesan Nair
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2005, Volume 591, Number 1-2, Page 34
Eun-Sun Hwang and Phyllis E. Bowen
Critical Reviews in Food Science and Nutrition, 2007, Volume 47, Number 1, Page 27
Natalie Jones, Stefanie Vogt, Maartje Nielsen, Daria Christian, Petra A. Wark, Diana Eccles, Emma Edwards, D. Gareth Evans, Eamonn R. Maher, Hans F. Vasen, Frederik J. Hes, Stefan Aretz, and Julian R. Sampson
Gastroenterology, 2009, Volume 137, Number 2, Page 489
Peter R. Hillestrøm, Maria-Isabel Covas, and Henrik E. Poulsen
Free Radical Biology and Medicine, 2006, Volume 41, Number 7, Page 1133
Armelle Munnia, Maria Enrica Amasio, and Marco Peluso
Free Radical Biology and Medicine, 2004, Volume 37, Number 6, Page 850
Urmila Nair, Helmut Bartsch, and Jagadeesan Nair
Free Radical Biology and Medicine, 2007, Volume 43, Number 8, Page 1109
Armelle Munnia, Stefano Bonassi, Anna Verna, Roberto Quaglia, David Pelucco, Marcello Ceppi, Monica Neri, Marina Buratti, Emanuela Taioli, Seymour Garte, and Marco Peluso
Free Radical Biology and Medicine, 2006, Volume 41, Number 9, Page 1499
Jae-Hong Park, So-Young Park, Dong-Ho Lee, Young-Shin Kim, and Mi-Ae Yoo
Journal of Life Science, 2011, Volume 21, Number 2, Page 194
F Khallouki, C Younos, R Soulimani, T Oster, Z Charrouf, B Spiegelhalder, H Bartsch, and R W Owen
European Journal of Cancer Prevention, 2003, Volume 12, Number 1, Page 67
Conor Crean, Jie Shao, Byeong Hwa Yun, Nicholas E. Geacintov, and Vladimir Shafirovich
Chemistry - A European Journal, 2009, Volume 15, Number 40, Page 10634
Eduard Escrich, M. Carmen Ramírez-Tortosa, Pedro Sánchez-Rovira, Ramon Colomer, Montserrat Solanas, and José Juan Gaforio
Nutrition Reviews, 2006, Volume 64, Page S40
Eunice Laurent, James W. McCoy, Roberto A. Macina, Wenhui Liu, Guangjie Cheng, Sylvie Robine, Jackie Papkoff, and J. David Lambeth
International Journal of Cancer, 2008, Volume 123, Number 1, Page 100
Nataliya V. Rohr-Udilova, Klaus Stolze, Sandra Sagmeister, Hans Nohl, Rolf Schulte-Hermann, and Bettina Grasl-Kraupp
Molecular Nutrition & Food Research, 2008, Volume 52, Number 3, Page 352
Tova Rainis, Irit Maor, Amos Lanir, Sergay Shnizer, and Alexandra Lavy
Digestive Diseases and Sciences, 2007, Volume 52, Number 2, Page 526
Ulrike Knust, Gerhard Erben, Bertold Spiegelhalder, Helmut Bartsch, and Robert Wyn Owen
Rapid Communications in Mass Spectrometry, 2006, Volume 20, Number 20, Page 3119
Andr� Nkondjock and Parviz Ghadirian
International Journal of Cancer, 2004, Volume 110, Number 1, Page 110

Comments (0)

Please log in or register to comment.
Log in