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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred


IMPACT FACTOR 2018: 3.014
5-year IMPACT FACTOR: 3.162

CiteScore 2018: 3.09

SCImago Journal Rank (SJR) 2018: 1.482
Source Normalized Impact per Paper (SNIP) 2018: 0.820

Online
ISSN
1437-4315
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Volume 383, Issue 6

Issues

Recent Aspects of Oxidative DNA Damage: Guanine Lesions, Measurement and Substrate Specificity of DNA Repair Glycosylases

Jean Cadet / Sophie Bellon / Maurice Berger / Anne-Gaëlle Bourdat / Thierry Douki / Victor Duarte / Sandrine Frelon / Didier Gasparutto / Evelyne Muller / Jean-Luc Ravanat / Sylvie Sauvaigo
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/BC.2002.100

Abstract

This review discusses recent aspects of oxidation reactions of DNA and model compounds involving mostly .OH radicals, oneelectron transfer process and singlet oxygen ([1]O[2]). Emphasis is placed on the formation of double DNA lesions involving a purine base on one hand and either a pyrimidine base or a 2-deoxyribose moiety on the other hand. Structural and mechanistic information is also provided on secondary oxidation reactions of 8-oxo-7,8-dihydro-2deoxyguanosine (8- oxodGuo), a major DNA marker of oxidative stress. Another major topic which is addressed here deals with recent developments in the measurement of oxidative base damage to cellular DNA. This has been mostly achieved using the accurate and highly specific HPLC method coupled with the tandem mass spectrometry detection technique. Interestingly, optimized conditions of DNA extraction and subsequent workup allow the accurate measurement of 11 modified nucleosides and bases within cellular DNA upon exposure to oxidizing agents, including UVA and ionizing radiations. In addition, the modified comet assay, which involves the use of bacterial DNA Nglycosylases to reveal two main classes of oxidative base damage, is applicable to isolated cells and is particularly suitable when only small amounts of biological material are available. Finally, recently available data on the substrate specificity of DNA repair enzymes belonging to the base excision pathways are briefly reviewed.

About the article

Published Online: 2005-06-01

Published in Print: 2002-06-26


Citation Information: Biological Chemistry, Volume 383, Issue 6, Pages 933–943, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2002.100.

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